Journal of Neurogastroenterology and Motility

The Korean Society of Neurogastroenterology and Motility (대한소화기 기능성질환 운동학회)
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Prevalence and Risk Factors of Functional Dyspepsia in Health Check-up Population: A Nationwide Multicenter Prospective Study

  • Kim, Sung Eun (Department of Internal Medicine, Kosin University College of Medicine) ;
  • Kim, Nayoung (Department of Internal Medicine, Seoul National University Bundang Hospital) ;
  • Lee, Ju Yup (Department of Internal Medicine, Keimyung University College of Medicine) ;
  • Park, Kyung Sik (Department of Internal Medicine, Keimyung University College of Medicine) ;
  • Shin, Jeong Eun (Department of Internal Medicine, Dankook University College of Medicine) ;
  • Nam, Kwangwoo (Department of Internal Medicine, Dankook University College of Medicine) ;
  • Kim, Hyeon Ju (Department of Family Medicine, Jeju National University School of Medicine) ;
  • Song, Hyun Joo (Department of Internal Medicine, Jeju National University School of Medicine) ;
  • Joo, Young-Eun (Department of Internal Medicine, Chonnam National University Medical School) ;
  • Myung, Dae-Seong (Department of Internal Medicine, Chonnam National University Medical School) ;
  • Seo, Ji-Hyun (Department of Internal Medicine, Seoul National University Bundang Hospital) ;
  • Jo, Hyun Jin (Department of Internal Medicine, Seoul National University Bundang Hospital) ;
  • Kim, Seon Mie (Department of Internal Medicine, Seoul National University Bundang Hospital) ;
  • Lim, Seon Hee (Departments of Internal Medicine, Healthcare system Gangnam Center Seoul National University Hospital, and Healthcare Research Institute) ;
  • Kim, Hyun Jin (Department of Internal Medicine and Institute of Health Science, Gyeongsang National University School of Medicine) ;
  • Baik, Gwang Ho (Department of Internal Medicine, Hallym University College of Medicine) ;
  • Choi, Sang Hyeon (Department of Internal Medicine, Hallym University College of Medicine) ;
  • Choi, Suck Chei (Department of Internal Medicine, Wonkwang University College of Medicine)
  • Received : 2018.04.06
  • Accepted : 2018.06.10
  • Published : 2018.10.30
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Abstract

Background/Aims Functional dyspepsia (FD) is one of the most common gastrointestinal disorders, and FD imposes social and economic burden worldwide. The aim of this study is to identify the prevalence and risk factors of FD in health check-up population in tertiary centers in Korea. Methods A nationwide multicenter prospective study was performed at 9 tertiary healthcare centers in Korea between September 2016 and June 2017. A total of 2525 subjects were investigated based on endoscopic findings and questionnaires with the Rome III criteria, and Helicobacter pylori serology (IgG). Results A total of 1714 subjects without organic disease were enrolled. The mean (${\pm}SD$) age was 51.5 (${\pm}12.7$) years, and 917 patients (53.5%) were female. The proportion of H. pylori seropositivity was 51.0% (874/1714). The prevalence of FD was 10.3% (176/1714), and the subtypes of postprandial distress syndrome alone, epigastric pain syndrome alone, and postprandial distress syndromeepigastric pain syndrome overlap were 4.8%, 3.0%, and 2.5%, respectively. Multivariate analysis showed that female gender (OR, 1.58; 95% CI, 1.14-2.21) and education below college level (OR, 1.45; 95% CI, 1.01-2.07) were related to FD. Multivariate analysis based on age 60 showed female gender as a significant (OR, 2.90; 95% CI, 1.06-7.94) factor in the group ${\geq}60$ years. Conclusions The prevalence of FD was 10.3% in the health check-up population in Korea. Female sex and education below college level were risk factors for FD. Female sex is a risk factor for FD in old age, underscoring the need for close attention in this age group.

Keywords

Acknowledgement

Supported by : National Research Foundation of Korea (NRF)

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