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Palliative and end-of-life care for heart failure patients in an aging society

  • Okumura, Takahiro (Department of Cardiology, Nagoya University Graduate School of Medicine) ;
  • Sawamura, Akinori (Department of Cardiology, Nagoya University Graduate School of Medicine) ;
  • Murohara, Toyoaki (Department of Cardiology, Nagoya University Graduate School of Medicine)
  • Received : 2018.03.16
  • Accepted : 2018.03.22
  • Published : 2018.11.01

Abstract

The populations of Asian countries are expected to age rapidly in the near future, with a dramatic increase in the number of heart failure (HF) patients also anticipated. The need for palliative and end-of-life care for elderly patients with advanced HF is currently recognized in aging societies. However, palliative care and active treatment for HF are not mutually exclusive, and palliative care should be provided to reduce suffering occurring at any stage of symptomatic HF after the point of diagnosis. HF patients are at high risk of sudden cardiac death from the early stages of the disease onwards. The decision of whether to perform cardiopulmonary resuscitation in the event of an emergency is challenging, especially in elderly HF patients, because of the difficulty in accurately predicting the prognosis of the condition. Furthermore, advanced HF patients are often fitted with a device, and device deactivation at the end of life is a complicated process. Treatment strategies should thus be discussed by multi-disciplinary teams, including palliative experts, and should consider patient directives to address the problems discussed above. Open communication with the HF patient regarding the expected prognosis, course, and treatment options will serve to support the patient and aid in future planning.

Keywords

References

  1. Yasobant S. Comprehensive public health action for our aging world: the quintessence of public health policy. J Int Med Res 2018;46:555-556. https://doi.org/10.1177/0300060517718452
  2. United Nations, Department of Economic and Social Affairs, Population Division. World population prospects: the 2017 revision [Internet]. New York: United Nations, 2017 [cited 2018 Mar 22]. Available from: https://esa.un-.org/unpd/wpp/.
  3. Shimokawa H, Miura M, Nochioka K, Sakata Y. Heart failure as a general pandemic in Asia. Eur J Heart Fail 2015; 17:884-892. https://doi.org/10.1002/ejhf.319
  4. Cabinet office, Government of Japan. Annual report on the aging society: 2016 (summary) [Internet]. Tokyo (JP): Cabinet office, Government of Japan, c2014 [cited 2018 Mar 22]. Available from: http://www8.cao.go.jp/kourei/english/annualreport/2016/pdf/c1-1.pdf.
  5. United Nations, Department of Economic and Social Affairs, Population Division. World population prospects: the 2015 revision [Internet]. New York: United Nations, 2017 [cited 2018 Mar 22]. Available from: https://esa.un-.org/unpd/wpp/.
  6. National Institute of Population and Social Security Research. Latest Demographic Statistics 2016. Population Research Series. Tokyo (JP): National Institute of Population and Social Security Research, 2016.
  7. Christiansen MN, Kober L, Weeke P, et al. Age-specific trends in incidence, mortality, and comorbidities of heart failure in Denmark, 1995 to 2012. Circulation 2017;135:1214-1223. https://doi.org/10.1161/CIRCULATIONAHA.116.025941
  8. Dharmarajan K, Rich MW. Epidemiology, pathophysiology, and prognosis of heart failure in older adults. Heart Fail Clin 2017;13:417-426. https://doi.org/10.1016/j.hfc.2017.02.001
  9. Rajadurai J, Tse HF, Wang CH, Yang NI, Zhou J, Sim D. Understanding the epidemiology of heart failure to improve management practices: an Asia-Pacific perspective. J Card Fail 2017;23:327-339. https://doi.org/10.1016/j.cardfail.2017.01.004
  10. Ambrosy AP, Fonarow GC, Butler J, et al. The global health and economic burden of hospitalizations for heart failure: lessons learned from hospitalized heart failure registries. J Am Coll Cardiol 2014;63:1123-1133. https://doi.org/10.1016/j.jacc.2013.11.053
  11. Lloyd-Jones DM, Larson MG, Leip EP, et al. Lifetime risk for developing congestive heart failure: the Framingham Heart Study. Circulation 2002;106:3068-3072. https://doi.org/10.1161/01.CIR.0000039105.49749.6F
  12. Sakata Y, Shimokawa H. Epidemiology of heart failure in Asia. Circ J 2013;77:2209-2217. https://doi.org/10.1253/circj.CJ-13-0971
  13. Sato N. Epidemiology of heart failure in Asia. Heart Fail Clin 2015;11:573-579. https://doi.org/10.1016/j.hfc.2015.07.009
  14. Okura Y, Ramadan MM, Ohno Y, et al. Impending epidemic: future projection of heart failure in Japan to the year 2055. Circ J 2008;72:489-491. https://doi.org/10.1253/circj.72.489
  15. Lee JH, Lim NK, Cho MC, Park HY. Epidemiology of heart failure in Korea: present and future. Korean Circ J 2016;46:658-664. https://doi.org/10.4070/kcj.2016.46.5.658
  16. Park JJ, Choi DJ. Heart failure epidemic: an expected phenomenon. Korean Circ J 2016;46:610-612. https://doi.org/10.4070/kcj.2016.46.5.610
  17. Ponikowski P, Voors AA, Anker SD, et al. 2016 ESC guidelines for the diagnosis and treatment of acute and chronic heart failure: the task force for the diagnosis and treatment of acute and chronic heart failure of the European Society of Cardiology (ESC) developed with the special contribution of the Heart Failure Association (HFA) of the ESC. Eur Heart J 2016;37:2129-2200. https://doi.org/10.1093/eurheartj/ehw128
  18. Lim SL, Lam CS. Breakthrough in heart failure with preserved ejection fraction: are we there yet? Korean J Intern Med 2016;31:1-14.
  19. Allen LA, Stevenson LW, Grady KL, et al. Decision making in advanced heart failure: a scientific statement from the American Heart Association. Circulation 2012;125:1928-1952. https://doi.org/10.1161/CIR.0b013e31824f2173
  20. McIlvennan CK, Allen LA. Palliative care in patients with heart failure. BMJ 2016;353:i1010.
  21. Lanken PN, Terry PB, Delisser HM, et al. An official American Thoracic Society clinical policy statement: palliative care for patients with respiratory diseases and critical illnesses. Am J Respir Crit Care Med 2008;177:912-927. https://doi.org/10.1164/rccm.200605-587ST
  22. Ghashghaei R, Yousefzai R, Adler E. Palliative care in heart failure. Prog Cardiovasc Dis 2016;58:455-460. https://doi.org/10.1016/j.pcad.2016.01.002
  23. Yumino D. Home medical care for heart failure. Yakugaku Zasshi 2016;136:1133-1136. https://doi.org/10.1248/yakushi.15-00271-5
  24. Wordingham SE, McIlvennan CK, Dionne-Odom JN, Swetz KM. Complex care options for patients with advanced heart failure approaching end of life. Curr Heart Fail Rep 2016;13:20-29. https://doi.org/10.1007/s11897-016-0282-z
  25. Mizuno A, Miyashita M, Hayashi A, et al. Potential palliative care quality indicators in heart disease patients: a review of the literature. J Cardiol 2017;70:335-341. https://doi.org/10.1016/j.jjcc.2017.02.010
  26. Lee H, Oh SH, Cho H, Cho HJ, Kang HY. Prevalence and socio-economic burden of heart failure in an aging society of South Korea. BMC Cardiovasc Disord 2016;16:215. https://doi.org/10.1186/s12872-016-0404-2
  27. Sato Y. Multidisciplinary management of heart failure just beginning in Japan. J Cardiol 2015;66:181-188. https://doi.org/10.1016/j.jjcc.2015.01.007
  28. World Health Organization. The World Health Report 2002: Reducing Risks, Promoting Healthy Life. Geneva: World Health Organization, 2002.
  29. Chen-Scarabelli C, Saravolatz L, Hirsh B, Agrawal P, Scarabelli TM. Dilemmas in end-stage heart failure. J Geriatr Cardiol 2015;12:57-65.
  30. Qaseem A, Snow V, Shekelle P, et al. Evidence-based inter ventions to improve the palliative care of pain, dyspnea, and depression at the end of life: a clinical practice guideline from the American College of Physicians. Ann Intern Med 2008;148:141-146. https://doi.org/10.7326/0003-4819-148-2-200801150-00009
  31. Hui D, Nooruddin Z, Didwaniya N, et al. Concepts and definitions for "actively dying," "end of life," "terminally ill," "terminal care," and "transition of care": a systematic review. J Pain Symptom Manage 2014;47:77-89. https://doi.org/10.1016/j.jpainsymman.2013.02.021
  32. Goodlin SJ. End-of-life care in heart failure. Curr Cardiol Rep 2009;11:184-191. https://doi.org/10.1007/s11886-009-0027-7
  33. Hunt SA, Abraham WT, Chin MH, et al. 2009 Focused update incorporated into the ACC/AHA 2005 guidelines for the diagnosis and management of heart failure in adults a report of the American College of Cardiology Foundation/American Heart Association task force on practice guidelines developed in collaboration with the International Society for Heart and Lung Transplantation. J Am Coll Cardiol 2009;53:e1-e90. https://doi.org/10.1016/j.jacc.2008.11.013
  34. Japanese Circulation Society. Statement for end-stage cardiovascular care (JCS 2010) [Internet]. Tokyo (JP): Japanese Circulation Society, 2010 [cited 2018 Mar 22]. Available from: http://www.j-circ.or.jp/guideline/pdf/JCS2010_nonogi_ h.pdf. Japanese.
  35. Lamont EB. A demographic and prognostic approach to defining the end of life. J Palliat Med 2005;8 Suppl 1:S12-S21. https://doi.org/10.1089/jpm.2005.8.s-12
  36. Yancy CW, Jessup M, Bozkurt B, et al. 2013 ACCF/AHA guideline for the management of heart failure: executive summary: a report of the American College of Cardiology Foundation/American Heart Association task force on practice guidelines. Circulation 2013;128:1810-1852. https://doi.org/10.1161/CIR.0b013e31829e8807
  37. Fang JC, Ewald GA, Allen LA, et al. Advanced (stage D) heart failure: a statement from the Heart Failure Society of America Guidelines Committee. J Card Fail 2015;21:519-534. https://doi.org/10.1016/j.cardfail.2015.04.013
  38. Thoonsen B, Engels Y, van Rijswijk E, et al. Early identification of palliative care patients in general practice: development of RADboud indicators for PAlliative Care Needs (RADPAC). Br J Gen Pract 2012;62:e625-e631. https://doi.org/10.3399/bjgp12X654597
  39. Murray SA, Boyd K, Sheikh A. Palliative care in chronic illness. BMJ 2005;330:611-612.
  40. Psotka MA, McKee KY, Liu AY, Elia G, De Marco T. Palliative care in heart failure: what triggers specialist consultation? Prog Cardiovasc Dis 2017;60:215-225. https://doi.org/10.1016/j.pcad.2017.05.001
  41. Kavalieratos D, Mitchell EM, Carey TS, et al. "Not the 'grim reaper service'": an assessment of provider knowledge, attitudes, and perceptions regarding palliative care referral barriers in heart failure. J Am Heart Assoc 2014;3:e000544.
  42. Huynh BC, Rovner A, Rich MW. Long-term survival in elderly patients hospitalized for heart failure: 14-year follow-up from a prospective randomized trial. Arch Intern Med 2006;166:1892-1898. https://doi.org/10.1001/archinte.166.17.1892
  43. Huynh BC, Rovner A, Rich MW. Identification of older patients with heart failure who may be candidates for hospice care: development of a simple four-item risk score. J Am Geriatr Soc 2008;56:1111-1115. https://doi.org/10.1111/j.1532-5415.2008.01756.x
  44. Morrison RS, Meier DE. Clinical practice. Palliative care. N Engl J Med 2004;350:2582-2590. https://doi.org/10.1056/NEJMcp035232
  45. World Health Organization. Palliative care fact sheet 2017 [Internet]. Geneva: World Health Organization, c2018 [cited 2018 Mar 22]. Available from: http://www.who.int/mediacentre/factsheets/fs402/en/.
  46. Connor SR, Bermedo MCS; Worldwide Palliative Care Alliance; World Health Organization. Global Atlas of Palliative Care at the End of Life. London: Worldwide Palliative Care Alliance, 2014.
  47. Setoguchi S, Glynn RJ, Stedman M, Flavell CM, Levin R, Stevenson LW. Hospice, opiates, and acute care service use among the elderly before death from heart failure or cancer. Am Heart J 2010;160:139-144. https://doi.org/10.1016/j.ahj.2010.03.038
  48. Cowie MR, Woehrle H, Wegscheider K, et al. Adaptive servo-ventilation for central sleep apnea in systolic heart failure. N Engl J Med 2015;373:1095-1105. https://doi.org/10.1056/NEJMoa1506459
  49. Momomura S, Seino Y, Kihara Y, et al. Adaptive servo-ventilation therapy for patients with chronic heart failure in a confirmatory, multicenter, randomized, controlled study. Circ J 2015;79:981-990. https://doi.org/10.1253/circj.CJ-15-0221
  50. Levenson JW, McCarthy EP, Lynn J, Davis RB, Phillips RS. The last six months of life for patients with congestive heart failure. J Am Geriatr Soc 2000;48(5 Suppl):S101-S109. https://doi.org/10.1111/j.1532-5415.2000.tb03119.x
  51. Evangelista LS, Sackett E, Dracup K. Pain and heart failure: unrecognized and untreated. Eur J Cardiovasc Nurs 2009;8:169-173. https://doi.org/10.1016/j.ejcnurse.2008.11.003
  52. Bleumink GS, Feenstra J, Sturkenboom MC, Stricker BH. Nonsteroidal anti-inflammatory drugs and heart failure. Drugs 2003;63:525-534. https://doi.org/10.2165/00003495-200363060-00001
  53. Hauptman PJ, Mikolajczak P, George A, et al. Chronic inotropic therapy in end-stage heart failure. Am Heart J 2006;152:1096.
  54. O'Connor CM, Jiang W, Kuchibhatla M, et al. Safety and efficacy of sertraline for depression in patients with heart failure: results of the SADHART-CHF (Sertraline Against Depression and Heart Disease in Chronic Heart Failure) trial. J Am Coll Cardiol 2010;56:692-699. https://doi.org/10.1016/j.jacc.2010.03.068
  55. Nicholas Dionne-Odom J, Hooker SA, Bekelman D, et al. Family caregiving for persons with heart failure at the intersection of heart failure and palliative care: a state-ofthe- science review. Heart Fail Rev 2017;22:543-557. https://doi.org/10.1007/s10741-017-9597-4
  56. McClung JA. End-of-life care in the treatment of heart failure in older adults. Heart Fail Clin 2017;13:633-644. https://doi.org/10.1016/j.hfc.2017.02.014
  57. Bekelman DB, Hutt E, Masoudi FA, Kutner JS, Rumsfeld JS. Defining the role of palliative care in older adults with heart failure. Int J Cardiol 2008;125:183-190. https://doi.org/10.1016/j.ijcard.2007.10.005
  58. Yokoshiki H, Shimizu A, Mitsuhashi T, et al. Survival and heart failure hospitalization in patients with cardiac resynchronization therapy with or without a defibrillator for primary prevention in Japan: analysis of the Japan Cardiac Device Treatment Registry Database. Circ J 2017;81:1798-1806. https://doi.org/10.1253/circj.CJ-17-0234
  59. Yancy CW, Jessup M, Bozkurt B, et al. 2017 ACC/AHA/HFSA focused update of the 2013 ACCF/AHA guideline for the management of heart failure: a report of the American College of Cardiology/American Heart Association task force on clinical practice guidelines and the Heart Failure Society of America. Circulation 2017;136:e137-e161.
  60. Pettit SJ, Browne S, Hogg KJ, et al. ICDs in end-stage heart failure. BMJ Support Palliat Care 2012;2:94-97. https://doi.org/10.1136/bmjspcare-2011-000176
  61. Park KH, Lee CH, Jung BC, et al. Effectiveness of implantable cardioverter-defibrillator therapy for heart failure patients according to ischemic or non-ischemic etiology in Korea. Korean Circ J 2017;47:72-81. https://doi.org/10.4070/kcj.2016.0242
  62. Goldstein NE, Lampert R, Bradley E, Lynn J, Krumholz HM. Management of implantable cardioverter defibrillators in end-of-life care. Ann Intern Med 2004;141:835-838. https://doi.org/10.7326/0003-4819-141-11-200412070-00006
  63. Kirklin JK, Pagani FD, Kormos RL, et al. Eighth annual INTERMACS report: special focus on framing the impact of adverse events. J Heart Lung Transplant 2017;36:1080-1086. https://doi.org/10.1016/j.healun.2017.07.005
  64. Nakatani T, Sase K, Oshiyama H, et al. Japanese registry for mechanically assisted circulatory support: first report. J Heart Lung Transplant 2017;36:1087-1096. https://doi.org/10.1016/j.healun.2017.08.002
  65. Yoshioka D, Toda K, Ono M, et al. Clinical results, adverse events, and change in end-organ function in elderly patients with HeartMateII left ventricular assist device: Japanese multicenter study. Circ J 2018;82:409-418. https://doi.org/10.1253/circj.CJ-17-0881
  66. Starling RC, Estep JD, Horstmanshof DA, et al. Risk assessment and comparative effectiveness of left ventricular assist device and medical management in ambulatory heart failure patients: the ROADMAP study 2-year results. JACC Heart Fail 2017;5:518-527. https://doi.org/10.1016/j.jchf.2017.02.016
  67. Huang R, Deng M, Rogers JG, et al. Effect of age on outcomes after left ventricular assist device placement. Transplant Proc 2006;38:1496-1498. https://doi.org/10.1016/j.transproceed.2006.02.115
  68. Shapiro PA, Levin HR, Oz MC. Left ventricular assist devices. Psychosocial burden and implications for heart transplant programs. Gen Hosp Psychiatry 1996;18(6 Suppl): 30S-35S. https://doi.org/10.1016/S0163-8343(96)00076-X
  69. Matsue Y, Damman K, Voors AA, et al. Time-to-furosemide treatment and mortality in patients hospitalized with acute heart failure. J Am Coll Cardiol 2017;69:3042-3051. https://doi.org/10.1016/j.jacc.2017.04.042
  70. Ladha A, Sharma S, Batsis JA, Hanson GA, Swetz KM. Care of the frail elder: the nexus of geriatrics and palliative care. Minn Med 2013;96:39-42.
  71. Gill TM, Gahbauer EA, Han L, Allore HG. Trajectories of disability in the last year of life. N Engl J Med 2010; 362:1173-1180. https://doi.org/10.1056/NEJMoa0909087
  72. Brunner-La Rocca HP, Rickenbacher P, Muzzarelli S, et al. End-of-life preferences of elderly patients with chronic heart failure. Eur Heart J 2012;33:752-759. https://doi.org/10.1093/eurheartj/ehr404
  73. Hattori A, Matsuda Y, Fetters MD, et al. A quantitative exploration of elderly patients' preferences for end-of-life care. Japan Med Assoc J 2005;48:388-397.
  74. Carson P, Anand I, O'Connor C, et al. Mode of death in advanced heart failure: the Comparison of Medical, Pacing, and Defibrillation Therapies in Heart Failure (COMPANION) trial. J Am Coll Cardiol 2005;46:2329-2334. https://doi.org/10.1016/j.jacc.2005.09.016
  75. Teuteberg JJ, Lewis EF, Nohria A, et al. Characteristics of patients who die with heart failure and a low ejection fraction in the new millennium. J Card Fail 2006;12:47-53. https://doi.org/10.1016/j.cardfail.2005.08.001
  76. Derfler MC, Jacob M, Wolf RE, Bleyer F, Hauptman PJ. Mode of death from congestive heart failure: implications for clinical management. Am J Geriatr Cardiol 2004;13:299-304. https://doi.org/10.1111/j.1076-7460.2004.03476.x
  77. Butterworth AM. Advance directives. Vital to quality care for elderly patients. Adv Nurse Pract 2004;12:69-75.
  78. Pope TM, Hexum M. Legal briefing: POLST: physician orders for life-sustaining treatment. J Clin Ethics 2012;23:353-376.
  79. Guidelines for emergency physicians on the interpretation of physician orders for life-sustaining therapy (POLST). Ann Emerg Med 2017;70:122-125. https://doi.org/10.1016/j.annemergmed.2017.04.046
  80. Ethics Committee, Japanese Society of Intensive Care Medicine. Physician orders for life-sustaining treatment (POLST) and do not attempt resuscitation (DNAR) order. J Japan Soc Intensive Care Med 2017;24:216-226. https://doi.org/10.3918/jsicm.24_216
  81. Silveira MJ, Kim SY, Langa KM. Advance directives and outcomes of surrogate decision making before death. N Engl J Med 2010;362:1211-1218. https://doi.org/10.1056/NEJMsa0907901
  82. Brinkman-Stoppelenburg A, Rietjens JA, van der Heide A. The effects of advance care planning on end-of-life care: a systematic review. Palliat Med 2014;28:1000-1025. https://doi.org/10.1177/0269216314526272
  83. End of Life Care Programme. Advance care planning: a guide for health and social care staff [Internet]. Leicester (UK): National Council for Palliative Care, c2015 [cited 2018 Mar 22]. Available from: http://www.ncpc.org.uk/sites/default/files/AdvanceCarePlanning.pdf.
  84. Sudore RL, Lum HD, You JJ, et al. Defining advance care planning for adults: a consensus definition from a multidisciplinary Delphi panel. J Pain Symptom Manage 2017;53:821-832. https://doi.org/10.1016/j.jpainsymman.2016.12.331
  85. Murray SA, Boyd K, Kendall M, Worth A, Benton TF, Clausen H. Dying of lung cancer or cardiac failure: prospective qualitative interview study of patients and their carers in the community. BMJ 2002;325:929. https://doi.org/10.1136/bmj.325.7370.929
  86. Kim J, Kim S, Shin MS, Jin JO, Kim Y, Lee MO. A context-oriented communication algorithm for advance care planning: a model to assist palliative care in heart failure. J Cardiovasc Nurs 2018;33:446-452. https://doi.org/10.1097/JCN.0000000000000396
  87. Goodlin SJ, Trupp R, Bernhardt P, Grady KL, Dracup K. Development and evaluation of the "Advanced Heart Failure Clinical Competence Survey": a tool to assess knowledge of heart failure care and self-assessed competence. Patient Educ Couns 2007;67:3-10. https://doi.org/10.1016/j.pec.2007.01.013
  88. Hauptman PJ, Swindle J, Hussain Z, Biener L, Burroughs TE. Physician attitudes toward end-stage heart failure: a national survey. Am J Med 2008;121:127-135. https://doi.org/10.1016/j.amjmed.2007.08.035
  89. Allen LA, Yager JE, Funk MJ, et al. Discordance between patient-predicted and model-predicted life expectancy among ambulatory patients with heart failure. JAMA 2008;299:2533-2542. https://doi.org/10.1001/jama.299.21.2533
  90. Murray SA, Kendall M, Grant E, Boyd K, Barclay S, Sheikh A. Patterns of social, psychological, and spiritual decline toward the end of life in lung cancer and heart failure. J Pain Symptom Manage 2007;34:393-402. https://doi.org/10.1016/j.jpainsymman.2006.12.009

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