The Korean Journal of Urological Oncology (대한비뇨기종양학회지)

Korean Urological Oncology Society (대한비뇨기종양학회)
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Comparison of Prognosis in Types 1 and 2 Papillary Renal Cell Carcinoma and Clear Cell Renal Cell Carcinoma in T1 Stage

  • Lee, Jaehoon (Department of Urology, Asan Medical Center, University of Ulsan College of Medicine) ;
  • Chae, Han Kyu (Department of Urology, Asan Medical Center, University of Ulsan College of Medicine) ;
  • Lee, Wonchul (Department of Urology, Asan Medical Center, University of Ulsan College of Medicine) ;
  • Nam, Wook (Department of Urology, Asan Medical Center, University of Ulsan College of Medicine) ;
  • Lim, Bumjin (Department of Urology, Asan Medical Center, University of Ulsan College of Medicine) ;
  • Choi, Se Young (Department of Urology, Asan Medical Center, University of Ulsan College of Medicine) ;
  • Kyung, Yoon Soo (Department of Urology, Asan Medical Center, University of Ulsan College of Medicine) ;
  • You, Dalsan (Department of Urology, Asan Medical Center, University of Ulsan College of Medicine) ;
  • Jeong, In Gab (Department of Urology, Asan Medical Center, University of Ulsan College of Medicine) ;
  • Song, Cheryn (Department of Urology, Asan Medical Center, University of Ulsan College of Medicine) ;
  • Hong, Bumsik (Department of Urology, Asan Medical Center, University of Ulsan College of Medicine) ;
  • Hong, Jun Hyuk (Department of Urology, Asan Medical Center, University of Ulsan College of Medicine) ;
  • Ahn, Hanjong (Department of Urology, Asan Medical Center, University of Ulsan College of Medicine) ;
  • Kim, Choung-Soo (Department of Urology, Asan Medical Center, University of Ulsan College of Medicine)
  • Received : 2018.09.10
  • Accepted : 2018.10.18
  • Published : 2018.12.30
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Abstract

Purpose: We compared subtypes of papillary renal cell carcinoma (pRCC; types 1 and 2) and clear cell renal cell carcinoma (ccRCC) in patients with T1-stage RCC to analyze the impact of the subtype on oncological outcomes. Materials and Methods: This paper reviewed 75 patients with pRCC and 252 patients with ccRCC at T1-stage from 1998-2012. Thus, we assessed the impact of subtype on oncologic outcomes among patients with T1-stage RCC. We used Kaplan-Meier analysis to estimate the overall survival and recurrence-free survival The median follow-up duration was 95 months (interquartile range, 75.4-119.3 months). Results: The 5-year recurrence-free survivals of pRCC and ccRCC were 95.4% and 97.6%, respectively. pRCC is worse than ccRCC in terms of recurrence-free survival (p=0.008) and there was no significant difference in the overall survival between pRCC and ccRCC (p=0.32). In addition, there was no significant statistical difference between type 1 pRCC and type 2 pRCC in terms of either recurrence-free survival (p=0.526) or overall survival (p=0.701). Age (hazard ratio [HR], 1.069; p<0.001) and recurrence (HR, 4.93; p<0.001) were predictors of overall survival. Only tumor size (HR, 1.071; p=0.004) was predictors in the case of cancer specific survival in the multivariate analysis. Conclusions: Among patients with T1-stage RCC, recurrence after surgery was more common in pRCC than ccRCC. The subtype of pRCC (types 1 and 2) had no impact on the recurrence-free survival or overall survival.

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References

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