Journal of Veterinary Clinics (한국임상수의학회지)

The Korean Society of Veterinary Clinics (한국임상수의학회)
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Suspected Case of Exocrine Pancreatic Insufficiency in a Bengal Tiger (Panthera tigris tigris)

  • Rhim, Haerin (Laboratory of Wildlife Medicine/Diseases, College of Veterinary Medicine, Chonbuk National University) ;
  • Han, Jae-Ik (Laboratory of Wildlife Medicine/Diseases, College of Veterinary Medicine, Chonbuk National University)
  • Received : 2018.07.27
  • Accepted : 2018.10.02
  • Published : 2018.10.31
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Abstract

A 1-year-old, female Bengal tiger (Panthera tigris tigris) presented signs of weight loss and dark browncolored diarrhea. On fecal examination, numerous intact and broken red blood cells were found, but both parasites and inflammatory signs were absent. No significant findings were seen in serum biochemistry profiles, including electrolytes, with negative feline pancreatic lipase immunoreactivity (fPLI). Diagnostic kits using feces or peripheral blood were negative for feline parvovirus, feline coronavirus, feline immunodeficiency virus, and feline leukemia virus. Based on the result of feline trypsin-like immunoreactivity (fTLI) concentration ($4.6{\mu}g/L$), the tiger was provisionally diagnosed to have exocrine pancreatic insufficiency (EPI). After this diagnosis, pancreatic enzymes were prescribed. The feces of the tiger returned to normal form and her weight was increasing. EPI is uncommon and not described extensively in Felidae, including domestic cats. Feline EPI is associated with a variety of non-specific signs and it should be considered in the differential diagnosis of cases presenting with weight loss, diarrhea, and other gastrointestinal signs. In this case, the patient was strongly suspected to have EPI based on the very low fTLI concentration, though the concentration of fTLI in tigers has not yet been determined. This is the first report to present a suspected EPI case in Bengal tigers.

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References

  1. Steiner JM. Exocrine Pancreatic Insufficiency in the Cat. Top Companion Anim Med 2012; 27: 113-116. https://doi.org/10.1053/j.tcam.2012.04.005
  2. Thompson KA, Parnell NK, Hohenhaus AE, Moore GE and Rondeau MP. Feline exocrine pancreatic insufficiency: 16 cases (1992-2007). J Feline Med. Surg. 2009; 11: 935-940. https://doi.org/10.1016/j.jfms.2009.04.004
  3. Steiner JM, Williams DA. Serum feline trypsin-like immunoreactivity in cats with exocrine pancreatic insufficiency. J Vet Intern Med 2000; 14: 627-629. https://doi.org/10.1111/j.1939-1676.2000.tb02288.x
  4. Steiner JM, Washabau RJ. Canine and Feline pancreatic diseases. Ettinger SJ, Feldman EC. In: Textbook of Veterinary Internal Medicine. 7th ed. St Louis, Missouri, USA: Saunders Elsevier; 2010; 2: 1296-1325.
  5. Williams DA. Feline exocrine pancreatic insufficiency. Kirk RW, Bonagura JD. In: Current veterinary therapy xii: small animal practice. Philadelphia, USA: WB Saunders, 1995; 732-735.
  6. Kennedy OC, Williams DA. Exocrine Pancreatic Insufficiency in Dogs and Cats: Online Support for Veterinarians and Owners. Top Companion Anim Med 2012; 27: 117-122. https://doi.org/10.1053/j.tcam.2012.05.001
  7. Steiner JM: Exocrine pancreatic insufficiency. August JR. In: Consultations in Feline Medicine. St Louis, Missouri, Saunders Elsevier, 2010; 225-231.
  8. DiMagno EP, Go VL, Summerskill WH. Relations between pancreatic enzyme outputs and malabsorption in severe pancreatic insufficiency. N Engl J Med 1973; 288: 813-815. https://doi.org/10.1056/NEJM197304192881603
  9. Xenoulis PG, Fradkin JM, Rapp SW, Suchodolski JS, Steiner JM. Suspected isolated pancreatic lipase deficiency in a dog. J Vet Intern Med 2007; 21: 1113-1116. https://doi.org/10.1111/j.1939-1676.2007.tb03073.x
  10. Steiner JM, Williams DA. Validation of a radioimmunoassay for feline trypsin-like immunoreactivity (fTLI) and serum cobalamin and folate concentrations in cats with exocrine pancreatic insufficiency. J Vet Intern Med 1995; 9: 193.
  11. Kook PH, Zerbe P, Reusch CE: Exocrine pancreatic insufficiency in the cat. Schweiz Arch Tierheilkd 2011; 153: 19-25. https://doi.org/10.1024/0036-7281/a000138
  12. Simpson KW, Fyfe J, Cornetta A, Sachs A, Strauss-Ayali D, Lamb SV, Reimers TJ. Subnormal concentrations of serum cobalamin (vitamin B12) in cats with gastrointestinal disease. J Vet Intern Med 2001; 15: 26-32. https://doi.org/10.1111/j.1939-1676.2001.tb02293.x
  13. Ruaux CG, Steiner JM, Williams DA. Metabolism of amino acids in cats with severe cobalamin deficiency. Am J Vet Res 2001; 62: 1852-1858. https://doi.org/10.2460/ajvr.2001.62.1852
  14. Larsen S. Diabetes mellitus secondary to chronic pancreatitis. Dan Med Bull 1993; 40: 153-162.
  15. Fleeman LM, Rand JS, Steiner JM, Williams DA. Chronic, subclinical, exocrine pancreatic disease is common in diabetic dogs. J Vet Intern Med 2004; 18: 402.
  16. Steiner JM, Williams DA, Moeller EM, Melgarejo T. Development and validation of an enzyme-linked immunosorbent assay for feline trypsin-like immunoreactivity. Am J Vet Res 2000; 61: 620-623. https://doi.org/10.2460/ajvr.2000.61.620
  17. Packer RA, Cohn LA, Wohlstadter DR, Shelton GD, Naylor JM, Zello GA, Ewaschuk JB, Williams DA, Ruaux CG, O'Brien DP. D-lactic acidosis secondary to exocrine pancreatic insufficiency in a cat. J Vet Intern Med 2005; 19: 106-110. https://doi.org/10.1111/j.1939-1676.2005.tb02667.x
  18. Williams DA, Reed SD. Comparison of methods for assay of fecal proteolytic activity. Vet Clin Pathol 1990; 19: 20-24. https://doi.org/10.1111/j.1939-165X.1990.tb00536.x
  19. Williams DA, Reed SD, Perry LA. Fecal proteolytic activity in clinically normal cats and in a cat with exocrine pancreatic insufficiency. J Am Vet Med Assoc 1990; 197: 210-212.

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