한국임상수의학회지 (Journal of Veterinary Clinics)

  • 제35권5호
  • /
  • Pages.229-232
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  • 2018
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  • 1598-298X(pISSN)
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  • 2384-0749(eISSN)
한국임상수의학회 (The Korean Society of Veterinary Clinics)
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Clinical Application of Autologous Platelet-Rich Plasma (PRP) on Delayed Wound Healing of a Dog with Burns

  • Lee, Shinho (Department of Veterinary Medicine, College of Veterinary Medicine, Jeju National University) ;
  • Cheong, Jongtae (Department of Veterinary Medicine, College of Veterinary Medicine, Jeju National University) ;
  • Lee, Joo-Myoung (Department of Veterinary Medicine, College of Veterinary Medicine, Jeju National University)
  • 투고 : 2018.08.17
  • 심사 : 2018.10.05
  • 발행 : 2018.10.31
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초록

A 9-year-old intact female Poodle (weighing 3.6 kg) was presented for the treatment of a partial and full thickness burn that covering 45% of body including bilateral thigh and sacrolumbar region. Autologous platelet-rich plasma (PRP) stimulates angiogenesis, promoting vascular in-growth and fibroblast proliferation. On the unrecovered right thigh of the dog, autologous PRP was injected into the lesion after application of micro-needles. For macroscopic evaluation digital, photographs were taken from wounds at days 0, 3, 5, 13, 21, and 28. On the $3^{rd}$ day after PRP application, epithelialization was accelerated. Application of autologous PRP accelerated wound-healing rate and healing time in full thickness burns as well as secondary complications originating from unrecovered wounds. The delayed lesion was completely healed on the $28^{th}$ day by autologous PRP treatment. In human, PRP was increasingly used in the treatment of a variety of soft tissue in the management of chronic non-healing wounds. This study has shown that PRP treatment can be a valuable and effective aid on intractable wound healing in the dog with burns.

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참고문헌

  1. Abegao KG, Bracale BN, Delfim IG, Santos ES, Laposy CB, Nai GA, Nogueir, RM. Effects of heterologous platelet-rich plasma gel on standardized dermal wound healing in rabbits. Acta Cir Bras, 2015; 30: 209-215. https://doi.org/10.1590/S0102-865020150030000008
  2. Abuaf OK, Yildiz H, Baloglu H, Bilgili ME, Simsek HA, Dogan B. Histologic Evidence of New Collagen Formulation Using Platelet Rich Plasma in Skin Rejuvenation: A Prospective Controlled Clinical Study. Ann Dermatol 2016; 28: 718-724. https://doi.org/10.5021/ad.2016.28.6.718
  3. Araki J, Jona M, Eto H, Aoi N, Kato H, Suga H, Yoshimura K. Optimized preparation method of platelet-concentrated plasma and noncoagulating platelet-derived factor concentrates: maximization of platelet concentration and removal of fibrinogen. Tissue Eng Part C Methods 2012; 18: 176-185.
  4. Bohling MW. Burns. In: Veterinary Surgery Small Animal. Tobias KM, Johnston SA (eds). Elsevier: St Louis, 2014; 1291-1302.
  5. Calderon Mdel S, Figueroa CS, Arias JS, Sandoval AH, Torre FO. Combined therapy of Ulmo honey (Eucryphia cordifolia) and ascorbic acid to treat venous ulcers. Rev Lat Am Enfermagem 2015; 23: 259-266. https://doi.org/10.1590/0104-1169.0020.2550
  6. Canapp SO, Jr. Leasure CS, Cox C, Ibrahim V, Carr BJ. Partial Cranial Cruciate Ligament Tears Treated with Stem Cell and Platelet-Rich Plasma Combination Therapy in 36 Dogs: A Retrospective Study. Front Vet Sci 2016; 3: 112.
  7. Carter CA, Jolly DG, Worden CE, Sr. Hendren DG, Kane CJ. Platelet-rich plasma gel promotes differentiation and regeneration during equine wound healing. Exp Mol Pathol 2006; 74: 244-255.
  8. Crovetti G, Martinelli G, Issi M, Barone M, Guizzardi M, Campanati B, Carabelli A. Platelet gel for healing cutaneous chronic wounds. Transfus Apher Sci 2004; 30: 145-151. https://doi.org/10.1016/j.transci.2004.01.004
  9. DeSanti L. Pathophysiology and current management of burn injury. Adv Skin Wound Care 2005; 18: 323-332. https://doi.org/10.1097/00129334-200507000-00013
  10. Fernandez-Moure JS, Van Eps JL, Cabrera FJ, Barbosa Z, Medrano Del Rosal G, Weiner BK, Tasciotti E. Platelet-rich plasma: a biomimetic approach to enhancement of surgical wound healing. J Surg Res 2017; 207: 33-44. https://doi.org/10.1016/j.jss.2016.08.063
  11. Franceschi F, Papalia R, Franceschetti E, Paciotti M, Maffulli N, Denaro V. Platelet-rich plasma injections for chronic plantar fasciopathy: a systematic review. Br Med Bull 2014; 112: 83-95. https://doi.org/10.1093/bmb/ldu025
  12. Hatakeyama I, Marukawa E, Takahashi Y, Omura K. Effects of platelet-poor plasma, platelet-rich plasma, and plateletrich fibrin on healing of extraction sockets with buccal dehiscence in dogs. Tissue Eng Part A 2014; 20: 874-882.
  13. Hermeto LC, Rossi Rd Padua SB, Pontes ER, Santana AE. Comparative study between fibrin glue and platelet rich plasma in dogs skin grafts. Acta Cir Bras 2012; 27: 789-794. https://doi.org/10.1590/S0102-86502012001100008
  14. Kakudo N, Kushida S, Minakata T, Suzuki K, Kusumoto K. Platelet-rich plasma promotes epithelialization and angiogenesis in a split thickness skin graft donor site. Med Mol Morphol 2011; 44: 233-236. https://doi.org/10.1007/s00795-010-0532-1
  15. Kazakos K, Lyras DN, Verettas D, Tilkeridis K, Tryfonidis M. The use of autologous PRP gel as an aid in the management of acute trauma wounds. Injury 2009; 40: 801-805. https://doi.org/10.1016/j.injury.2008.05.002
  16. Kim YC, Park JH, Prausnitz MR. Microneedles for drug and vaccine delivery. Adv Drug Deliv Rev 2012; 64: 1547-1568. https://doi.org/10.1016/j.addr.2012.04.005
  17. Lee JH, Kim MJ, Ha SW, Kim HK. Autologous Plateletrich Plasma Eye Drops in the Treatment of Recurrent Corneal Erosions. Korean J Ophthalmol 2016; 30: 101-107. https://doi.org/10.3341/kjo.2016.30.2.101
  18. Liu M, Lu J, Muller P, Turnbull L, Burke CM, Schlothauer RC, Harry EJ. Antibiotic-specific differences in the response of Staphylococcus aureus to treatment with antimicrobials combined with manuka honey. Front Microbiol 2014; 5: 779.
  19. Lu Y. Effects of "surrounding needling" on hydroxyproline content and ultrastructures in the dermis of aged rats. Zhongguo Zhen Jiu 2008; 28: 61-64.
  20. Marquez-de-Aracena R, Montero-de-Espinosa I, Munoz M, Pereira G. Subconjunctival application of plasma platelet concentrate in the treatment of ocular burns. Preliminary results. Arch Soc Esp Oftalmol 2007; 82: 475-481.
  21. Monteiro SO, Lepage OM, Theoret CL. Effects of plateletrich plasma on the repair of wounds on the distal aspect of the forelimb in horses. Am J Vet Res 2009; 70: 277-282. https://doi.org/10.2460/ajvr.70.2.277
  22. Nofal E, Helmy A, Nofal A, Alakad R, Nasr M. Platelet-rich plasma versus CROSS technique with 100% trichloroacetic acid versus combined skin needling and platelet rich plasma in the treatment of atrophic acne scars: a comparative study. Dermatol Surg 2014; 40: 864-873.
  23. Pallua N, Wolter T, Markowicz M. Platelet-rich plasma in burns. Burns 2010; 36: 4-8. https://doi.org/10.1016/j.burns.2009.05.002
  24. Quist EM, Tanabe M, Mansell JE, Edwards JL. A case series of thermal scald injuries in dogs exposed to hot water from garden hoses (garden hose scalding syndrome). Vet Dermatol 2012; 23: 162-166 https://doi.org/10.1111/j.1365-3164.2011.01015.x
  25. Safdar A, Shaaban H, Tibayan R, Miller R, Boairdo R, Guron G. The clinical efficacy of using autologous platelet rich plasma in hip arthroplasty: A retrospective comparative study. J Nat Sci Biol Med 2015; 6: 49-55.
  26. Salemi S, Rinaldi C, Manna F, Guarneri GF, Parodi PC. Reconstruction of lower leg skin ulcer with autologous adipose tissue and platelet-rich plasma. J Plast Reconstr Aesthet Surg 2008; 61: 1565-1567. https://doi.org/10.1016/j.bjps.2008.04.048
  27. Tang, Y. Q., Yeaman, M. R., & Selsted, M. E. (2002). Antimicrobial peptides from human platelets. Infect Immun, 70: 6524-6533. https://doi.org/10.1128/IAI.70.12.6524-6533.2002
  28. Tiwari VK. Burn wound: How it differs from other wounds? Indian J Plast Surg 2012; 45: 364-373. https://doi.org/10.4103/0970-0358.101319
  29. Tozum TF, Demiralp B. Platelet-rich plasma: a promising innovation in dentistry. J Can Dent Assoc 2003; 69: 664.
  30. Zhang J, Middleton KK, Fu FH, Im HJ, Wang JH. HGF mediates the anti-inflammatory effects of PRP on injured tendons. PLoS One 2013; 8.