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Successful Management of a Life Threatening Canine Multicentric Lymphoma with Pulmonary Thromboembolism

  • Moon, Min-Young (Department of Veterinary Internal Medicine, College of Veterinary Medicine, Chonnam National University) ;
  • Suh, Guk-Hyun (Department of Veterinary Internal Medicine, College of Veterinary Medicine, Chonnam National University) ;
  • Choi, Hyeong-Il (Department of Veterinary Internal Medicine, College of Veterinary Medicine, Chonnam National University) ;
  • Kim, Joonyoung (Department of Veterinary Internal Medicine, College of Veterinary Medicine, Chonnam National University) ;
  • Kim, Ha-Jung (Department of Veterinary Internal Medicine, College of Veterinary Medicine, Chonnam National University)
  • Received : 2018.08.22
  • Accepted : 2018.10.13
  • Published : 2018.10.31

Abstract

A 12-year-old, intact female Jindo was referred to our clinic due to the enlargement of all lymph nodes, as well as severe dyspnea. All palpatible lymph nodes were highly swelling and enlargement. The dog was diagnosed as end stage of multicentric lymphoma with multi-organ metastasis. In addition, the dog was diagnosed as having a pulmonary thromboembolism via computed tomography (CT) and D-dimer concentrations and prothrombin time (PT) results. This case report describes that lymphoma can be associated with pulmonary thromboembolism which is life threatening complication in dogs. The present case was managed successfully with chemotherapy and antithrombotic treatment.

Keywords

References

  1. Almirall L, Az-Ricart M, Bastida E, Ordinas A. The role of platelets in Cancer metastasis. Blood Coagul Fibrinolysis 1990; 1: 707-711.
  2. Andreasen E, Jensen AL, Jessen LR, Kristensen AT, Wiinberg B. Evaluation of human recombinant tissue factoractivated thromboelastography in 49 dogs with neoplasia. J Vet Intern Med 2008; 22: 140-147. https://doi.org/10.1111/j.1939-1676.2008.0030.x
  3. Andrew DB, Simon D. Arterial and venous thrombosis in cancer patients. Card Res Pract 2011: 394-740.
  4. Armelle DL. Diseases Associated with Thrombosis. Topics in Companion Animal Medicine 2012; 27: 59-64. https://doi.org/10.1053/j.tcam.2012.07.002
  5. Baines EA, Stidworthy MF. Watson PJ. Gross pulmonary thrombosis in a greyhound. J Small Anim Pract 2001; 42: 448-452. https://doi.org/10.1111/j.1748-5827.2001.tb02499.x
  6. Baker DC, Johnson LR, Lappin MR. Pulmonary thromboembolism in 29 dogs (1985-1995). J Vet Intern Med 1999; 13: 338-345.
  7. Bell WR, Levin J, Sack GH Jr, Trousseau's syndrome and other manifestations of chronic disseminated coagulopathy in patients with neoplasms: clinical, pathophysiologic, and therapeutic features. Medicine (Baltimore) 1977; 56: 1-37. https://doi.org/10.1097/00005792-197756010-00001
  8. Brooks MB, McCullough SM, Stokol-Moncrieff JC, Treadwell NG. Hemostatic abnormalities in dogs with primary immunemediated hemolytic anemia. JAAHA 2001; 61: 393-398.
  9. Caine GJ, Kehoe ST, Lip GY, Stonelake PS. The hypercoagulable state of malignancy: pathogenesis and current debate. Neoplasia 2002; 4: 465-473. https://doi.org/10.1038/sj.neo.7900263
  10. Calzolari D, Morini S, Venco L. Pulmonary thromboembolism in a dog with renal amyloidosis. Vet Radiol Ultrasound 1998; 39: 564-565. https://doi.org/10.1111/j.1740-8261.1998.tb01652.x
  11. Carr AP, Kidd L, Panciera DL. Prognostic factors for mortality and thromboembolism in canine immune-mediated hemolytic anemia: a retrospective study of 72 dogs. J Vet Intern Med 2002; 16: 504-509. https://doi.org/10.1111/j.1939-1676.2002.tb02378.x
  12. Donati MB, Cancer and thrombosis: from Phlegmasia alba dolens to transgenic mice. Thromb Haemost 1998; 74: 278-281.
  13. Donati MB, Falanga A. Pathogenesis of thrombosis in patients with malignancy. Int J Hematol 2001; 73: 137-144. https://doi.org/10.1007/BF02981929
  14. Donati MB. Thrombosis and cancer: a personal view. Thromb Haemost Pub Med 2007; 98: 126-128. https://doi.org/10.1160/TH07-05-0363
  15. Dow SW, Klein MK, Rosychuk RA. Pulmonary thromboembolism associated with immune-mediated hemolytic anemia in dogs: ten cases (1982-1987). J Am Vet Med Assoc 1989; 195: 246-250.
  16. Edwards RL, Levine M, Rickles FR. Hemostatic alterations in cancer patients. Cancer Metastasis Rev 1992; 11: 237-248. https://doi.org/10.1007/BF01307180
  17. Hylands R. Pulmonary thromboembolism. Can Vet J 2006; 47: 385-388.
  18. Janowska-Wieczorek A, Kijowski J, Machalinski B, Marquez-Curtis L, Ratajczak J, Ratajczak MZ, Wysoczynski M. Microvesicles derived from activated platelets induce metastasis and angiogenesis in lung cancer. Int J Cancer 2005; 113: 752-760. https://doi.org/10.1002/ijc.20657
  19. Kakkar AK, Nash GF, Scully MF, Turner LF. Platelets and cancer. Lancet Oncol 2002; 3: 425-430. https://doi.org/10.1016/S1470-2045(02)00789-1
  20. Kornreich B, Pembleton-Corbett JR, Schermerhorn T. Pulmonary thromboembolism in cats. J Vet Intern Med 2004; 18: 533-535. https://doi.org/10.1111/j.1939-1676.2004.tb02580.x
  21. Korte W. Cancer and thrombosis: an increasingly important association. Support Care Cancer 2008; 16: 223-228. https://doi.org/10.1007/s00520-007-0376-y
  22. LaRue MJ, Murtaugh RJ. Pulmonary thromboembolism in dogs: 47 cases (1986-1987). J Am Vet Med Assoc 1990; 197: 1368-1372.
  23. Liska WD, Poteet BA. Pulmonary embolism associated with canine total hip replacement. Vet Surg 2003; 32: 178-186. https://doi.org/10.1053/jvet.2003.50016
  24. Ritt MG, Rogers KS, Thomas JS. Nephrotic syndrome resulting in thromboembolic disease and disseminated intravascular coagulation in a dog. J Am Anim Hosp Assoc 1997; 33: 385-391. https://doi.org/10.5326/15473317-33-5-385
  25. Winter PC. The pathogenesis of venous thromboembolism in cancer: emerging links with tumour biology. Hematol Oncol 2006; 24: 126-133. https://doi.org/10.1002/hon.785