Journal of Medicine and Life Science

Institute for Medical Science (제주대학교 의과학연구소)
권호 표지
DOI QR코드

DOI QR Code

Understanding animal models on colorectal cancer

대장암 동물 모델에 대한 이해

  • 임도영 (Mayo 병원 소아청소년의학과)
  • Received : 2018.11.06
  • Accepted : 2018.11.21
  • Published : 2018.12.31
Download PDF
⟨ Previous Next ⟩

Abstract

Colorectal cancer (CRC) is a third leading cause of cancer-related death in cancer patients. Sporadic and inflammation-related colon carcinogenesis are major mechanism of colorectal cancer. In vivo CRC models have been developed and implicated to understand their mechanisms upon a different type of CRC. Moreover, recently animal models have played important roles in chemopreventive and preclinical trials over the years. In this mini-review, the aim is to introduce various animal models of CRC and help the understanding to establish in vivo experimental plans according to the cancer type of CRC.

Keywords

References

  1. Roser M, Ritchie H. Cancer. Published online at OurWroldInData. org. 2018. Available from: 'https://ourworldindata.org/cancer'
  2. de la Chapelle A. Genetic predisposition to colorectal cancer. Nat Rev Cancer 2004;4:769-80. https://doi.org/10.1038/nrc1453
  3. Gillen CD, Walmsley RS, Prior P, Andrews HA, Allan RN. Ulcerative colitis and Crohn's disease: a comparison of the colorectal cancer risk in extensive colitis. Gut 1994;35:1590-2. https://doi.org/10.1136/gut.35.11.1590
  4. Luongo C, Moser AR, Gledhill S, Dove WF. Loss of Apc (+) in Intestinal Adenomas from Min Mice. Cancer Research 1994;54:5947-52.
  5. Yamada Y, Mori H. Multistep carcinogenesis of the colon in Apc(Min/+) mouse. Cancer Sci 2007;98:6-10. https://doi.org/10.1111/j.1349-7006.2006.00348.x
  6. Amos-Landgraf JM, Kwong LN, Kendziorski CM, Reichelderfer M, Torrealba J, Weichert J, et al. A target-selected Apc-mutant rat kindred enhances the modeling of familial human colon cancer. Proc Natl Acad Sci U S A 2007;2104:4036-41.
  7. Johnson RL, Fleet JC. Animal models of colorectal cancer. Cnacre Metastasis Rev 2013;32:39-61. https://doi.org/10.1007/s10555-012-9404-6
  8. Irving AA, Yoshimi K, Hart ML, Parker T, Clipson L, Ford MR, et al. The utility of Apc-mutant rats in modeling human colon cancer. Dis Model Mech 2014;7:1215-25. https://doi.org/10.1242/dmm.016980
  9. Edelmann W, Yang F, Kuraguchi M, Heyer J, Lia M, Kneitz B, et al. Tumorigenesis in Mlh1 and Mlh1/Apc1638N mutant mice. Cancer Research 1999;59:1301-7.
  10. Reitmair AH, Redston M, Cai JC, Chuang TC, Bjerknes M, Cheng H, et al. Spontaneous intestinal carcinomas and skin neoplasms in Msh2-deficient mice. Cancer Res 1996;56:3842-9.
  11. Belcheva A, Irrazabal T, Robertson SJ, Streutker C, Maughan H, Rubino S, et al. Gut microbial metabolism drives transformation of MSH2-deficient colon epithelial cells. Cell 2014;158:288-99. https://doi.org/10.1016/j.cell.2014.04.051
  12. Yeo M, Surh YJ, Hahm KB. Molecular mechanism underlying the colitis-associated colorectal cancer. Korean J Med 2006;20:130-7. (Korean)
  13. Bansal P, Sonnenberg A. Risk factors of colorectal cancer in inflammatory bowel disease. Am J Gastroenterol 1996;91:44-8.
  14. Jass JR, Whitehall VL, Young J, Leggett BA. Emerging concepts in colorectal neoplasia. Gastroenterology 2002;123:862-76. https://doi.org/10.1053/gast.2002.35392
  15. Seril DN, Liao J, Yang GY, Yang CS. Oxidative stress and ulcerative colitis-associated carcinogenesis: studies in humans and animal models. Carcinogenesis 2002;24:353-62.
  16. Yamamoto Y, Gaynor RB. Therapeutic potential of inhibition of the NF-kappaB pathway in the treatment of inflammation and cancer. J Clin Invest 2001;107:135-42. https://doi.org/10.1172/JCI11914
  17. Yeo M, Kim DK, Park HJ, Oh TY, Kim JH, Cho SW, et al. Loss of transgelin in repeated bouts of ulcerative colitis-induced colon carcinogenesis. Proteomics 2006;6:1158-65. https://doi.org/10.1002/pmic.200500390
  18. Okayasu I, Yamada M, Mikami T, Yoshida T, Kanno J, Ohkusa T. Dysplasia and carcinoma development in a repeated dextran sulfate sodium-induced colitis model. J Gastroenterol Hepatol 2002;17:1078-83. https://doi.org/10.1046/j.1440-1746.2002.02853.x
  19. Tanaka T, Kohno H, Suzuki R, Yamada Y, Sugie S, Mori H. A novel inflammation-related mouse colon carcinogenesis model induced by azoxymethane and dextran sodium sulfate. Cancer Sci 2003;94:965-73. https://doi.org/10.1111/j.1349-7006.2003.tb01386.x
  20. De Robertis M, Massi E, Poeta ML, Carotti S, Morini S, Cecchetelli L, et al. The AOM/DSS murine model for the study of colon carcinogenesis: From pathways to diagnosis and therapy studies. J Carcinog 2011;10:9. https://doi.org/10.4103/1477-3163.78279