Effect of Stress and Serotonin-Transporter-Linked Polymorphic Region Variants on Internet Gaming Disorder in Korean Adults

한국 성인남녀에서 스트레스와 세로토닌 전달체(5-HTTLPR) 유전자 변이가 인터넷 게임장애(IGD)에 미치는 영향

  • Hong, Hyung-Sook (Department of Psychiatry, College of Medicine, The Catholic University of Korea) ;
  • Jeong, Jo-Eun (Department of Psychiatry, College of Medicine, The Catholic University of Korea) ;
  • Cho, Hyun (Addiction Laboratory, Department of Psychiatry, College of Medicine, The Catholic of University of Korea) ;
  • Kwak, Su-Min (Addiction Laboratory, Department of Psychiatry, College of Medicine, The Catholic of University of Korea) ;
  • Choi, Mi Ran (Addiction Laboratory, Department of Psychiatry, College of Medicine, The Catholic of University of Korea) ;
  • Choi, Jung-Seok (Department of Psychiatry, SMG-SNU Boramae Medical Center, Seoul National University College of Medicine) ;
  • Choi, Sam-Wook (Truemind Mental Health Clinic) ;
  • Kim, Dai-Jin (Department of Psychiatry, College of Medicine, The Catholic University of Korea)
  • 홍형숙 (가톨릭대학교 의과대학 정신과학교실) ;
  • 정조은 (가톨릭대학교 의과대학 정신과학교실) ;
  • 조현 (가톨릭대학교 의과대학 정신건강의학과 중독연구실) ;
  • 곽수민 (가톨릭대학교 의과대학 정신건강의학과 중독연구실) ;
  • 최미란 (가톨릭대학교 의과대학 정신건강의학과 중독연구실) ;
  • 최정석 (서울대학교 의과대학 정신과학교실) ;
  • 최삼욱 (진심정신건강의학과) ;
  • 김대진 (가톨릭대학교 의과대학 정신과학교실)
  • Received : 2018.04.20
  • Accepted : 2018.08.02
  • Published : 2018.08.31

Abstract

Objectives Internet gaming disorder (IGD) is known to be related to stress and the serotonin-transporter-linked polymorphic region (5-HTTLPR) that is known to be associated with stress and has been studied to affect various psychiatric illness outbreaks. We tried to examine the relationship between stress, 5-HTTLPR and IGD. Methods A total of 59 participants with IGD, diagnosed according to the 5th edition of the Diagnostic and Statistical Manual of Mental Disorders (DSM-5) criteria and 67 normal controls (NC) were enrolled. The IGD group and the NC were compared using chisquare test and independent sample t-test, and logistic regression analysis was used to examine the relationship between stress, the 5-HTTLPR, and IGD. Results The mean scores for anxiety, impulsivity and stress were significantly higher in the IGD group than in the NC. In addition, there was a significant association between stress and IGD [odds ratio (OR) = 1.172, 95% confidence interval (CI) = 1.008-1.362]. Conclusions This study showed that stress would affect IGD. Therefore, the evaluation and management of stress should be included in the diagnosis and treatment of IGD.

Keywords

References

  1. American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders. 5th ed. Arlington, VA: American Psychiatric Association;2013.
  2. Holden C. 'Behavioral' addictions: do they exist? Science 2001;294:980-982. https://doi.org/10.1126/science.294.5544.980
  3. Fauth-Buhler M, Mann K. Neurobiological correlates of internet gaming disorder: similarities to pathological gambling. Addict Behav 2017;64:349-356. https://doi.org/10.1016/j.addbeh.2015.11.004
  4. Choi SW, Kim HS, Kim GY, Jeon Y, Park SM, Lee JY, et al. Similarities and differences among internet gaming disorder, gambling disorder and alcohol use disorder: a focus on impulsivity and compulsivity. J Behav Addict 2014;3:246-253. https://doi.org/10.1556/JBA.3.2014.4.6
  5. Vink JM, van Beijsterveldt TC, Huppertz C, Bartels M, Boomsma DI. Heritability of compulsive Internet use in adolescents. Addict Biol 2016;21:460-468. https://doi.org/10.1111/adb.12218
  6. Dong G, Potenza MN. A cognitive-behavioral model of Internet gaming disorder: theoretical underpinnings and clinical implications. J Psychiatr Res 2014;58:7-11. https://doi.org/10.1016/j.jpsychires.2014.07.005
  7. Coman GJ, Burrows GD, Evans BJ. Stress and anxiety as factors in the onset of problem gambling: implications for treatment. Stress Health 1997;13:235-244.
  8. Samaha M, Hawi NS. Relationships among smartphone addiction, stress, academic performance, and satisfaction with life. Computers in Human Behavior 2016;57:321-325. https://doi.org/10.1016/j.chb.2015.12.045
  9. Cho HY, Kim DJ, Park JW. Stress and adult smartphone addiction: mediation by self-control, neuroticism, and extraversion. Stress Health 2017;33:624-630. https://doi.org/10.1002/smi.2749
  10. van der Aa N, Overbeek G, Engels RC, Scholte RH, Meerkerk GJ, Van den Eijnden RJ. Daily and compulsive internet use and well-being in adolescence: a diathesis-stress model based on big five personality traits. J Youth Adolesc 2009;38:765-776. https://doi.org/10.1007/s10964-008-9298-3
  11. Leung L. Stressful life events, motives for internet use, and social support among digital kids. Cyberpsychol Behav 2007;10:204-214. https://doi.org/10.1089/cpb.2006.9967
  12. Chaouloff F. Serotonin, stress and corticoids. J Psychopharmacol 2000;14:139-151. https://doi.org/10.1177/026988110001400203
  13. Nordquist N, Oreland L. Serotonin, genetic variability, behaviour, and psychiatric disorders--a review. Ups J Med Sci 2010;115:2-10. https://doi.org/10.3109/03009730903573246
  14. Karg K, Burmeister M, Shedden K, Sen S. The serotonin transporter promoter variant (5-HTTLPR), stress, and depression meta-analysis revisited: evidence of genetic moderation. Arch Gen Psychiatry 2011;68:444-454. https://doi.org/10.1001/archgenpsychiatry.2010.189
  15. Covault J, Tennen H, Armeli S, Conner TS, Herman AI, Cillessen AH, et al. Interactive effects of the serotonin transporter 5-HTTLPR polymorphism and stressful life events on college student drinking and drug use. Biol Psychiatry 2007;61:609-616. https://doi.org/10.1016/j.biopsych.2006.05.018
  16. Culverhouse RC, Saccone NL, Bierut LJ. The state of knowledge about the relationship between 5-HTTLPR, stress, and depression. J Affect Disord 2018;228:205-206. https://doi.org/10.1016/j.jad.2017.12.002
  17. Goldman N, Glei DA, Lin YH, Weinstein M. The serotonin transporter polymorphism (5-HTTLPR): allelic variation and links with depressive symptoms. Depress Anxiety 2010;27:260-269. https://doi.org/10.1002/da.20660
  18. Caspi A, Sugden K, Moffitt TE, Taylor A, Craig IW, Harrington H, et al. Influence of life stress on depression: moderation by a polymorphism in the 5-HTT gene. Science 2003;301:386-389. https://doi.org/10.1126/science.1083968
  19. Sen S, Burmeister M, Ghosh D. Meta-analysis of the association between a serotonin transporter promoter polymorphism (5-HTTLPR) and anxiety-related personality traits. Am J Med Genet B Neuropsychiatr Genet 2004;127B:85-89. https://doi.org/10.1002/ajmg.b.20158
  20. Liu L, Wang L, Cao C, Cao X, Zhu Y, Liu P, et al. Serotonin transporter 5-HTTLPR genotype is associated with intrusion and avoidance symptoms of DSM-5 posttraumatic stress disorder (PTSD) in Chinese earthquake survivors. Anxiety Stress Coping 2018;31:318-327. https://doi.org/10.1080/10615806.2017.1420174
  21. Lee YS, Han DH, Yang KC, Daniels MA, Na C, Kee BS, et al. Depression like characteristics of 5HTTLPR polymorphism and temperament in excessive internet users. J Affect Disord 2008;109:165-169. https://doi.org/10.1016/j.jad.2007.10.020
  22. Young KS. Internet addiction: the emergence of a new clinical disorder. CyberPsychology & Behavior 1998;1:237-244. https://doi.org/10.1089/cpb.1998.1.237
  23. Kang MC, Oh IS. Development of Korean internet addiction scales. Korean J Youth Counsel 2001;9:114-135.
  24. Derogatis LR, Unger R. Symptom checklist-90-revised. In: Craighead WE, editor. The Corsini Encyclopedia of Psychology. Hoboken, NJ: John Wiley & Sons;2010. p.1-2.
  25. Dickman SJ. Functional and dysfunctional impulsivity: personality and cognitive correlates. J Pers Soc Psychol 1990;58:95-102. https://doi.org/10.1037/0022-3514.58.1.95
  26. Lee GJ, Son CN. The effects of self - Instruction training on juvenile delinquents dysfunctional impulsivity and their responses in continuous performance test. Korean Journal of Clinical Psychology 2001;20:229-244.
  27. Cohen S, Kamarck T, Mermelstein R. A global measure of perceived stress. J Health Soc Behav 1983;24:385-396. https://doi.org/10.2307/2136404
  28. Lee SY, Lee HK, Jeong H, Yim HW, Bhang SY, Jo SJ, et al. The hierarchical implications of internet gaming disorder criteria: which indicate more severe pathology? Psychiatry Investig 2017;14:249-259. https://doi.org/10.4306/pi.2017.14.3.249
  29. National Information Society Agency. The survey on internet overdependence. Daegu: National Information Society Agency;2015.
  30. Dalbudak E, Evren C, Aldemir S, Coskun KS, Ugurlu H, Yildirim FG. Relationship of internet addiction severity with depression, anxiety, and alexithymia, temperament and character in university students. Cyberpsychol Behav Soc Netw 2013;16:272-278. https://doi.org/10.1089/cyber.2012.0390
  31. Yoo HJ, Cho SC, Ha J, Yune SK, Kim SJ, Hwang J, et al. Attention deficit hyperactivity symptoms and internet addiction. Psychiatry Clin Neurosci 2004;58:487-494. https://doi.org/10.1111/j.1440-1819.2004.01290.x
  32. Cao F, Su L, Liu T, Gao X. The relationship between impulsivity and Internet addiction in a sample of Chinese adolescents. Eur Psychiatry 2007;22:466-471. https://doi.org/10.1016/j.eurpsy.2007.05.004
  33. Ko CH, Yen JY, Yen CF, Chen CS, Chen CC. The association between internet addiction and psychiatric disorder: a review of the literature. Eur Psychiatry 2012;27:1-8.
  34. Bernardi S, Pallanti S. Internet addiction: a descriptive clinical study focusing on comorbidities and dissociative symptoms. Compr Psychiatry 2009;50:510-516. https://doi.org/10.1016/j.comppsych.2008.11.011
  35. Caplan SE. Relations among loneliness, social anxiety, and problematic internet use. Cyberpsychol Behav 2007;10:234-242. https://doi.org/10.1089/cpb.2006.9963
  36. Lee HW, Choi JS, Shin YC, Lee JY, Jung HY, Kwon JS. Impulsivity in internet addiction: a comparison with pathological gambling. Cyberpsychol Behav Soc Netw 2012;15:373-377. https://doi.org/10.1089/cyber.2012.0063
  37. Blaszczynski A, Nower L. A pathways model of problem and pathological gambling. Addiction 2002;97:487-499. https://doi.org/10.1046/j.1360-0443.2002.00015.x
  38. Zalsman G, Huang YY, Oquendo MA, Burke AK, Hu XZ, Brent DA, et al. Association of a triallelic serotonin transporter gene promoter region (5-HTTLPR) polymorphism with stressful life events and severity of depression. Am J Psychiatry 2006;163:1588-1593. https://doi.org/10.1176/ajp.2006.163.9.1588
  39. Mann JJ, Huang YY, Underwood MD, Kassir SA, Oppenheim S, Kelly TM, et al. A serotonin transporter gene promoter polymorphism (5-HTTLPR) and prefrontal cortical binding in major depression and suicide. Arch Gen Psychiatry 2000;57:729-738. https://doi.org/10.1001/archpsyc.57.8.729
  40. Frisch A, Postilnick D, Rockah R, Michaelovsky E, Postilnick S, Birman E, et al. Association of unipolar major depressive disorder with genes of the serotonergic and dopaminergic pathways. Mol Psychiatry 1999;4:389-392. https://doi.org/10.1038/sj.mp.4000536
  41. Han DH, Lee YS, Yang KC, Kim EY, Lyoo IK, Renshaw PF. Dopamine genes and reward dependence in adolescents with excessive internet video game play. J Addict Med 2007;1:133-138. https://doi.org/10.1097/ADM.0b013e31811f465f
  42. Jeong JE, Rhee JK, Kim TM, Kwak SM, Bang SH, Cho H, et al. The association between the nicotinic acetylcholine receptor ${\alpha}4$ subunit gene (CHRNA4) rs1044396 and internet gaming disorder in Korean male adults. PLoS One 2017;12:e0188358. https://doi.org/10.1371/journal.pone.0188358
  43. Young KS, Rogers RC. The relationship between depression and internet addiction. CyberPsychology & Behavior 1998;1:25-28. https://doi.org/10.1089/cpb.1998.1.25
  44. Kuss DJ, van Rooij AJ, Shorter GW, Griffiths MD, van de Mheen D. Internet addiction in adolescents: prevalence and risk factors. Computers in Human Behavior 2013;29:1987-1996 https://doi.org/10.1016/j.chb.2013.04.002
  45. Lee SY, Lee HK, Choo H. Typology of internet gaming disorder and its clinical implications. Psychiatry Clin Neurosci 2017;71:479-491. https://doi.org/10.1111/pcn.12457
  46. Kuss DJ, Griffiths MD, Karila L, Billieux J. Internet addiction: a systematic review of epidemiological research for the last decade. Curr Pharm Des 2014;20:4026-4052. https://doi.org/10.2174/13816128113199990617
  47. McLean CP, Asnaani A, Litz BT, Hofmann SG. Gender differences in anxiety disorders: prevalence, course of illness, comorbidity and burden of illness. J Psychiatr Res 2011;45:1027-1035. https://doi.org/10.1016/j.jpsychires.2011.03.006