대한한방내과학회지 (The Journal of Internal Korean Medicine)

대한한방내과학회 (The Society of Internal Korean Medicine)
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ICR 마우스를 이용한 전호의 단회경구투여 독성 실험

Single Dose Oral Toxicity Test of Peucedani Radix in ICR Mice

  • 권다혜 (동의대학교 한의과대학 생화학교실) ;
  • 김민영 (동의대학교 한의과대학 생화학교실) ;
  • 황보현 (부산대학교 분자생물학과) ;
  • 지선영 (동의대학교 한의과대학 생화학교실) ;
  • 박철 (동의대학교 자연과학대학 분자생물학과) ;
  • 최영현 (동의대학교 한의과대학 생화학교실) ;
  • 홍수현 (동의대학교 한의과대학 생화학교실)
  • Kwon, Da-hye (Dept. of Biochemistry, Dong-Eui University College of Korean Medicine) ;
  • Kim, Min-young (Dept. of Biochemistry, Dong-Eui University College of Korean Medicine) ;
  • Hwangbo, Hyun (Dept. of Molecular Biology, Pusan National University) ;
  • Ji, Seon-yeong (Dept. of Biochemistry, Dong-Eui University College of Korean Medicine) ;
  • Park, Cheol (Dept. of Molecular Biology, College of Natural Sciences and Human Ecology, Dong-Eui University) ;
  • Choi, Yung-hyun (Dept. of Biochemistry, Dong-Eui University College of Korean Medicine) ;
  • Hong, Su-hyun (Dept. of Biochemistry, Dong-Eui University College of Korean Medicine)
  • 투고 : 2018.09.06
  • 심사 : 2018.10.01
  • 발행 : 2018.09.30
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초록

Objectives: The aim of this study was to estimate the single oral toxicity of Peucedani Radix (PR) ethanol extracts. PR is one of the important herbs for removal of phlegm, the viscous turbid pathological product that can accumulate in the body and cause a variety of diseases. However, research on the pharmacologic toxicity of PR is lacking. Methods: In this study, PR was orally administered to 5-week-old male ICR mice at an oral dose of 2,000, 3,000, or 5,000 mg/kg. After a single-dose administration, the mortality and behavioral changes were observed daily and body weights were measured every two days. After 14 days, the organ weight, organ index, macroscopy, hematological analysis, and serum biochemistry analysis were determined. Results: No mortality, body weight changes, abnormal behavioral changes, or anatomical signs of toxicity were found. The organ weight, organ index, hematological analysis, and serum biochemistry analysis were also within the normal ranges. Conclusions: These results suggest that the 50% lethal dose of PR is more than 5,000 mg/kg. This could indicate that PR is a safe drug without acute toxicity and side effects.

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참고문헌

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피인용 문헌

  1. 선복화 에탄올 추출물의 급성 독성 연구 vol.28, pp.2, 2018, https://doi.org/10.14374/hfs.2020.28.2.169