The Journal of Internal Korean Medicine (대한한방내과학회지)

The Society of Internal Korean Medicine (대한한방내과학회)
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Correlation Analysis between Gastric Emptying Measurement by Ultrasonography and Korean Medical Questionnaires

초음파 위배출 측정과 한의설문 간의 상관성 분석

  • Cho, Soo-ho (Dept. of Internal Korean Medicine, Kyung Hee University Hospital at Gangdong) ;
  • Lee, Jae-hong (Dept. of Internal Korean Medicine, Kyung Hee University Hospital at Gangdong) ;
  • Ko, Seok-jae (Dept. of Internal Korean Medicine, Kyung Hee University Hospital at Gangdong) ;
  • Kim, Jin-sung (Dept. of Internal Korean Medicine, Kyung Hee University Hospital at Gangdong) ;
  • Park, Jae-woo (Dept. of Internal Korean Medicine, Kyung Hee University Hospital at Gangdong)
  • 조수호 (강동경희대학교 한방병원 한방내과) ;
  • 이재홍 (강동경희대학교 한방병원 한방내과) ;
  • 고석재 (강동경희대학교 한방병원 한방내과) ;
  • 김진성 (강동경희대학교 한방병원 한방내과) ;
  • 박재우 (강동경희대학교 한방병원 한방내과)
  • Received : 2018.08.28
  • Accepted : 2018.09.30
  • Published : 2018.09.30
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Abstract

Objective: This study was designed to investigate the correlation between gastric emptying measurement by ultrasonography and the findings of various questionnaires of functional dyspepsia (FD) or in Korean medicine to explore the possibility of quantification of questionnaires. Methods: Eighty-eight patients (44 patients with FD and 44 healthy controls) were recruited from October 2016 to November 2017. Gastric emptying half-time (T1/2) was measured by ultrasonography at fasting, and at 0, 15, 30, 45, 60, 90, and 120 min after meals (apple juice, 500 ml, 224 kcal). The average half-time (average T1/2) was calculated by averaging all measured half-times. A visual analogue scale (VAS), food retention questionnaire (FRQ), damum questionnaire (DQ), cold and heat questionnaire (CHQ), deficiency and excess questionnaire (DEQ), spleen-qi deficiency questionnaire (SQDQ), Nepean dyspepsia index-Korean version (NDI-K), and quality of life of NDI (NDI-QoL) were filled out by all participants. Correlation between the average T1/2 and questionnaires were analyzed for 79 patients (37 patients with FD and 42 healthy controls) after excluding missing and erroneous data. Results: The FRQ, DEQ, SQDQ, NDI-K, and NDI-QoL scores, especially for some gastrointestinal symptoms and general weakness-related symptoms, showed statistically significant correlations with average T1/2. Conclusions: Our results suggest that gastric emptying measurement by ultrasonography may be a quantitative substitute method for some Korean medical questionnaires or for some dyspepsia-related and deficiency-related items among them. However, further studies using various measurements of gastric emptying will be needed.

Keywords

References

  1. Shin CM, Huh KC. Diagnosis and treatment of functional dyspepsia. J Korean Med Assoc 2016; 59(4):311-8. https://doi.org/10.5124/jkma.2016.59.4.311
  2. Park JM, Choi MG, Cho YK, Lee IS, Kim JI, Kim SW, et al. Functional gastrointestinal disorders diagnosed by Rome III questionnaire in Korea. J Neurogastroenterol Motil 2011;17(3):279-86. https://doi.org/10.5056/jnm.2011.17.3.279
  3. Gentilcore D, Hausken T, Horowitz M, Jones KL. Measurements of gastric emptying of low-and high-nutrient liquids using 3D ultrasonography and scintigraphy in healthy subjects. Neurogastroenterol Motil 2006;18(12):1062-8. https://doi.org/10.1111/j.1365-2982.2006.00830.x
  4. Asano H, Tomita T, Nakamura K, Yamasaki T, Okugawa T, Kondo T, et al. Prevalence of Gastric Motility Disorders in Patients WIth Functional Dyspepsia. J Neurogastroenterol Motil 2017;23(3) :392-9. https://doi.org/10.5056/jnm16173
  5. Oh HW, Lee JW, Kim JS, Song EY, Shin SW, Han GJ, et al. Study on the Development of a Standard Instrument of Diagnosis and Assessment for Spleen Deficiency Pattern. J Korean Med 2014;35(1):157-70. https://doi.org/10.13048/jkm.14015
  6. Pathology of Korean Medicine Textbook Compilation Committee. Pathology of Korean Medicine. Seoul: han-ui munhwasa; 2008, p. 411-4.
  7. Beak SH, Kim JS. Correlation Analysis between Gastric Emptying Measured by Ultrasonography and Spleen Qi Deficiency Pattern in Patients with Functional Dyspepsia. J Int Korean Med 2015;36(4):527-46.
  8. Nam SU, Park JW, Kim JS. Correlation Analysis Between Stomach Qi Deficiency Pattern and Gastric Emptying Measured by Abdominal Ultrasonography in Patients with Functional Dyspepsia. J Int Korean Med 2018;39(3):405-25. https://doi.org/10.22246/jikm.2018.39.3.405
  9. Van de Putte P, Perlas A. Ultrasound assessment of gastric content and volume. British Journal of Anaesthesia 2014;113(1):12-22. https://doi.org/10.1093/bja/aeu151
  10. Lee HW, Park HJ, Lee SI, Park IS, Kang BC, Kim KH. Ultrasonographic Gastric Emptying in Patients with Functional Dyspepsia. The Korean Journal of gastroenterology 1998;31(1):1-8.
  11. Kim JB, Kim JH, Son CG, Kang WC, Cho JH. Development of instrument of Pattern identification for Functional Dyspepsia. Korean Journal of Oriental Physiology & Pathology 2010;24(6): 1094-8.
  12. Choi SH, Rhim HM, Oh JG, Rhim JY, Kang HW, Kim YS, et al. Standard Pattern Identifications for Post Stroke Depression by Delphi Method. Korean Journal of Oriental Physiology & Pathology 2012;26(3):367-75.
  13. Park YJ, Lim JS, Park YB. Development of a valid and reliable food retention questionnaire. European Journal of Integrative Medicine 2013; 5(5):432-7. https://doi.org/10.1016/j.eujim.2013.06.002
  14. Park JS, Yang DH, Kim MY, Lee SC, Park YJ. Development of Questionnaire for Damum Patternization. Journal of Korean institute of Oriental Medical Diagnostics 2006;10(1):64-77.
  15. Oh HW, Lee JW, Kim JS, Song EY, Shin SW, Han GJ, et al. Study on the Development of a Standard Instrument of Diagnosis and Assessment for Spleen Qi Deficiency Pattern. J Korean Med 2014;35(1):157-70. https://doi.org/10.13048/jkm.14015
  16. Talley NJ, Haque M, Wyeth JW, Stace NH, Tytgat GN, Stanghellini V, et al. Development of a new dyspepsia impact scale : the Nepean Dyspepsia Index. Aliment Pharmacol Ther 1999; 13(2):225-35. https://doi.org/10.1046/j.1365-2036.1999.00445.x
  17. Lee SY, Chi SC, Cho YK, Choi MG. Validation of the Nepean Dyspepsia Index-Korean version. Kor J Neurogastroenterol Motil 2003;9(suppl):48.
  18. Talley NJ, Verlinden M, Jones M. Can Symptoms Discriminate Among Those With Delayed or Normal Gastric Emptying in Dysmotility-Like Dyspepsia?. The American Journal of Gastroenterology 2001;96(5):1422-8. https://doi.org/10.1111/j.1572-0241.2001.03683.x
  19. Talley NJ, Locke III GR, Lahr BD, Zinsmeister AR, Tougas G, Ligozio G, et al. Functional dyspepsia, delayed gastric emptying, and impaired quality of life. Gut 2006;55(7):933-9. https://doi.org/10.1136/gut.2005.078634
  20. Kim SE, Park HK, Kim NY, Joo YE, Baik GH, Shin JE, et al. Prevalence and Risk Factors of Functional Dyspepsia : A Nationwide Multicenter Prospective Study in Korea. J Clin Gastroenterol 2014;48(2):e12-8. https://doi.org/10.1097/MCG.0b013e31828f4bc9
  21. Stanghellini V, Chan FK, Hasler WL, Malagelada JR, Suzuki H, Tack J, et al. Gastroduodenal Disorders. Gastroenterology 2016;150(6):1380-2. https://doi.org/10.1053/j.gastro.2016.02.011
  22. Drossman DA. The functional gastrointestinal disorders and the Rome III process. Gastroenterology 2006;130(5):1377-90. https://doi.org/10.1053/j.gastro.2006.03.008
  23. Darwiche G, Björgell O, Thorsson O, Almer LO. Correlation Between Simultaneous Scintigraphic and Ultrasonographic Measurement of Gastric Emptying in Patients With Type 1 Diabetes Mellitus. J Ultrasound Med 2003;22(5):459-66. https://doi.org/10.7863/jum.2003.22.5.459
  24. Kim DY, Jung HK, Lee YH, Jung SA, Moon IW, Paek JY. The Measurement of Gastric Emptying Time with 3-D Ultrasonography. The Korean Journal of Gastroenterology 2004;44(2) :71-6.
  25. Sakurada M, Oikawa N, Imai N, Yoda B, Toyota T, Goto Y, et al. Gastric Emptying Time Measured by Simple Two-step Ultrasonographic Method in Diabetic Patients. Journal Japan Diab Soc 1985;28(6):739-45.
  26. Kusunoki H, Haruma K, Manabe N, Imamura H, Kamada T, Shiotani A, et al. Therapeutic efficacy of acotiamide in patients with functional dyspepsia based on enhanced postprandial gastric accommodation and emptying : randomized controlled study evaluation by real-time ultrasonography. Neurogastroenterol Motil 2012;24(6):540-e251. https://doi.org/10.1111/j.1365-2982.2012.01897.x
  27. Pedersen JF. A Modified sonographic technique for assessment of gastric emptying of liquid. Acta Radiologica 2003;44(3):340-2. https://doi.org/10.1034/j.1600-0455.2003.00055.x
  28. Ahluwalia NK, Thompson DG, Mamtora H, Troncon L, Hindle J, Hollis S. Evlauation of human postprandial antral motor function using ultrasound. Am J Physiol 1994;266(3):517-22.
  29. Tack J, Piessevaux H, Coulie B, Caenepeel P, Janssens J. Role of impaired gastric accommodation to a meal in functional dyspepsia. Gastroenterology 1998;115(6):1346-52. https://doi.org/10.1016/S0016-5085(98)70012-5
  30. Zai H, Kusano M. Investigation of Gastric Emptying Disorders in Patients with Functional Dyspepsia Reveals Impaired Inhibitory Gastric Emptying Regulation in the Early Postcibal Period. Digestion 2009;79(suppl 1):13-8. https://doi.org/10.1159/000167861
  31. Kindt S, Tack J. Impaired gastric accommodation and its role in dyspepsia. Gut 2006;55(12): 1685-91. https://doi.org/10.1136/gut.2005.085365

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