Maxillofacial Plastic and Reconstructive Surgery

  • 제40권
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  • Pages.5.1-5.8
  • /
  • 2018
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  • 2288-8101(pISSN)
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  • 2288-8586(eISSN)
대한악안면성형재건외과학회 (Korean Association of Maxillofacial Plastic and Reconstructive Surgeons)
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Effect of the masseter muscle injection of botulinum toxin A on the mandibular bone growth of developmental rats

  • Seok, Hyun (Department of Oral and Maxillofacial Surgery, Chungbuk National University Hospital) ;
  • Kim, Seong-Gon (Department of Oral and Maxillofacial Surgery, College of Dentistry, Gangneung-Wonju National University) ;
  • Kim, Min-Keun (Department of Oral and Maxillofacial Surgery, College of Dentistry, Gangneung-Wonju National University) ;
  • Jang, Insan (Department of Orthodontics, College of Dentistry, Gangneung-Wonju National University) ;
  • Ahn, Janghoon (Department of Dentistry, College of Medicine, Hallym University)
  • 투고 : 2018.01.10
  • 심사 : 2018.02.21
  • 발행 : 2018.12.31
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초록

Background: The objective of this study was to evaluate the influence of masticatory muscle injection of botulinum toxin type A (BTX-A) on the growth of the mandibular bone in vivo. Methods: Eleven Sprague-Dawley rats were used, and BTX-A (n = 6) or saline (n = 5) was injected at 13 days of age. All injections were given to the right masseter muscle, and the BTX-A dose was 0.5 units. All of the rats were euthanized at 60 days of age. The skulls of the rats were separated and fixed with 10% formalin for micro-computed tomography (micro-CT) analysis. Results: The anthropometric analysis found that the ramus heights and bigonial widths of the BTX-A-injected group were significantly smaller than those of the saline-injected group (P < 0.05), and the mandibular plane angle of the BTX-A-injected group was significantly greater than in the saline-injected group (P < 0.001). In the BTX-A-injected group, the ramus heights II and III and the mandibular plane angles I and II showed significant differences between the injected and non-injected sides (P < 0.05). The BTX-A-injected side of the mandible in the masseter group showed significantly lower mandibular bone growth compared with the non-injected side. Conclusion: BTX-A injection into the masseter muscle influences mandibular bone growth.

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참고문헌

  1. Pearce LB, Borodic GE, First ER, MacCallum RD (1994) Measurement of botulinum toxin activity: evaluation of the lethality assay. Toxicol Appl Pharmacol 128:69-77 https://doi.org/10.1006/taap.1994.1181
  2. Moon YM, Kim MK, Kim SG, Kim TW (2016) Apoptotic action of botulinum toxin on masseter muscle in rats: early and late changes in the expression of molecular markers. Spring 5:1-11 https://doi.org/10.1186/s40064-015-1659-2
  3. Moon YM, Kim YJ, Kim MK, Kim SG, Kweon H, Kim TW (2015) Early effect of Botox-A injection into the masseter muscle of rats: functional and histological evaluation. Maxillofac Plast Reconstr Surg 37:46 https://doi.org/10.1186/s40902-015-0049-6
  4. Kwon TG (2016) Botulinum toxin related research in maxillofacial plastic and reconstructive surgery. Maxillofac Plast Reconstr Surg 38:34 https://doi.org/10.1186/s40902-016-0080-2
  5. Maio MD (2008) Therapeutic uses of botulinum toxin: from facial palsy to autonomic disorders. Expert Opin Biol Ther 8:791-798 https://doi.org/10.1517/14712598.8.6.791
  6. Jaspers G, Pijpe J, Jansma J (2011) The use of botulinum toxin type a in cosmetic facial procedures. Int J Oral Maxillofac Surg 40:127-133 https://doi.org/10.1016/j.ijom.2010.09.014
  7. Kim HS, Yun PY, Kim YK (2016) A clinical evaluation of botulinum toxin-A injections in the temporomandibular disorder treatment. Maxillofac Plast Reconstr Surg 38:5 https://doi.org/10.1186/s40902-016-0051-7
  8. Archana M (2016) Toxin yet not toxic: botulinum toxin in dentistry. Saudi Dent J 28:63-69 https://doi.org/10.1016/j.sdentj.2015.08.002
  9. Raadsheer MC, Kiliaridis S, van Eijden TM, van Ginkel FC, Prahl-Andersen B (1996) Masseter muscle thickness in growing individuals and its relation to facial morphology. Arch Oral Biol 41:323-332 https://doi.org/10.1016/0003-9969(95)00136-0
  10. Moss ML, Rankow RM (1968) The role of the functional matrix in mandibular growth. Angle Orthod 38:95-103
  11. Weijs W, Hillen B (1984) Relationships between masticatory muscle crosssection and skull shape. J Dent Res 63:1154-1157 https://doi.org/10.1177/00220345840630091201
  12. Kim JH, Lim SU, Jin KS, Lee H, Han YS (2017) The postoperative trismus, nerve injury and secondary angle formation after partial masseter muscle resection combined with mandibular angle reduction: a case report. J Korean Assoc Oral Maxillofac Surg 43:46-48 https://doi.org/10.5125/jkaoms.2017.43.1.46
  13. Kiliaridis S (1995) Masticatory muscle influence on craniofacial growth. Acta Odontol Scand 53:196-202 https://doi.org/10.3109/00016359509005972
  14. Bouvier M, Hylander WL (1984) The effect of dietary consistency on gross and histologic morphology in the craniofacial region of young rats. Am J Anat 170:117-126 https://doi.org/10.1002/aja.1001700109
  15. Maxwell LC, Carlson DS, McNamara JA, Faulkner JA (1979) Histochemical characteristics of the masseter and temporalis muscles of the rhesus monkey (macaca mulatta). Anat Rec 193:389-401 https://doi.org/10.1002/ar.1091930306
  16. Gardner DE, Luschei ES, Joondeph DR (1980) Alterations in the facial skeleton of the guinea pig following a lesion of the trigeminal motor nucleus. Am J Orthod 78:66-80 https://doi.org/10.1016/0002-9416(80)90040-8
  17. Tsai CY, Chiu WC, Liao YH, Tsai CM (2009) Effects on craniofacial growth and development of unilateral botulinum neurotoxin injection into the masseter muscle. Am J Orthodont Dentofac Orthoped 135:142 e141-142 e146
  18. Park SY, Park YW, Ji YJ, Park SW, Kim SG (2015) Effects of a botulinum toxin type A injection on the masseter muscle: an animal model study. Maxillofac Plast Reconstr Surg 37:10 https://doi.org/10.1186/s40902-015-0010-8
  19. Chen Z, Chen Z, Zhao N, Shen G (2015) An animal model for inducing deviation of the mandible. J Oral Maxillofac Surg 73:2207-2218 https://doi.org/10.1016/j.joms.2015.03.051
  20. Kun-Darbois JD, Libouban H, Chappard D (2015) Botulinum toxin in masticatory muscles of the adult rat induces bone loss at the condyle and alveolar regions of the mandible associated with a bone proliferation at a muscle enthesis. Bone 77:75-82 https://doi.org/10.1016/j.bone.2015.03.023
  21. Tsai CY, Huang RY, Lee CM, Hsiao WT, Yang LY (2010) Morphologic and bony structural changes in the mandible after a unilateral injection of botulinum neurotoxin in adult rats. J Oral Maxillofac Surg 68:1081-1087 https://doi.org/10.1016/j.joms.2009.12.009
  22. Kim JY, Kim ST, Cho SW, Jung HS, Park KT, Son HK (2008) Growth effects of botulinum toxin type A injected into masseter muscle on a developing rat mandible. Oral Dis 14:626-632 https://doi.org/10.1111/j.1601-0825.2007.01435.x
  23. Ulgen M, Baran S, Kaya H, Karadede I (1997) The influence of the masticatory hypofunction on the craniofacial growth and development in rats. Am J Orthodont Dentofac Orthoped 111:189-198 https://doi.org/10.1016/S0889-5406(97)70215-4
  24. Filippi GM, Errico P, Santarelli R, Bagolini B, Manni E (1993) Botulinum a toxin effects on rat jaw muscle spindles. Acta Otolaryngol 113:400-404 https://doi.org/10.3109/00016489309135834
  25. Tsai CY, Shyr YM, Chiu WC, Lee CM (2011) Bone changes in the mandible following botulinum neurotoxin injections. Eur J Orthod 33:132-138 https://doi.org/10.1093/ejo/cjq029
  26. Jost WH, Hefter H, Reissig A, Kollewe K, Wissel J (2014) Efficacy and safety of botulinum toxin type a (dysport) for the treatment of post-stroke arm spasticity: results of the german-austrian open-label post-marketing surveillance prospective study. J Neurol Sci 337:86-90 https://doi.org/10.1016/j.jns.2013.11.022
  27. Sarioglu B, Serdaroglu G, Tutuncuoglu S, Ozer EA (2003) The use of botulinum toxin type a treatment in children with spasticity. Pediatr Neurol 29:299-301 https://doi.org/10.1016/S0887-8994(03)00269-8
  28. Babuccu B, Babuccu O, Yurdakan G, Ankaral H (2009) The effect of the botulinum toxin-A on craniofacial development: an experimental study. Ann Plast Surg 63:449-456 https://doi.org/10.1097/SAP.0b013e31818d4559
  29. Roggenkamper P, Jost W, Bihari K, Comes G, Grafe S (2006) Efficacy and safety of a new botulinum toxin type a free of complexing proteins in the treatment of blepharospasm. J Neural Transm 113:303-312 https://doi.org/10.1007/s00702-005-0323-3
  30. Poliachik SL, Bain SD, Threet D, Huber P, Gross TS (2010) Transient muscle paralysis disrupts bone homeostasis by rapid degradation of bone morphology. Bone 46:18-23 https://doi.org/10.1016/j.bone.2009.10.025
  31. Ausk BJ, Huber P, Srinivasan S, Bain SD, Kwon RY, McNamara EA, Poliachik SL, Sybrowsky CL, Gross TS (2013) Metaphyseal and diaphyseal bone loss in the tibia following transient muscle paralysis are spatiotemporally distinct resorption events. Bone 57:413-422 https://doi.org/10.1016/j.bone.2013.09.009
  32. Park YW, Kim SG, Jo YY (2016) S100 and p65 expression are increased in the masseter muscle after botulinum toxin-A injection. Maxillofac Plast Reconstr Surg 38:33-33 https://doi.org/10.1186/s40902-016-0079-8
  33. Seok H, Park YT, Kim SG, Park YW (2013) Correction of post-traumatic anterior open bite by injection of botulinum toxin type A into the anterior belly of the digastric muscle: case report. J Korean Assoc Oral Maxillofac Surg 39:188-192 https://doi.org/10.5125/jkaoms.2013.39.4.188
  34. Seok H, Lee SW, Kim MK, Kim SG, Park YW, Park SW, Park YJ (2013) Correction of post-traumatic lower lip asymmetry using botulinum toxin type A. J Korean Assoc Maxillofac Plast Reconstr Surg 35:256-259
  35. Zdilla MJ (2015) Screening for variations in anterior digastric musculature prior to correction of post-traumatic anterior open bite by injection of botulinum toxin type A: a technical note. J Korean Assoc Oral Maxillofac Surg 41:165-167 https://doi.org/10.5125/jkaoms.2015.41.3.165
  36. Ko EWC, Huang CS, Lo LJ, Chen YR (2013) Alteration of masticatory electromyographic activity and stability of orthognathic surgery in patients with skeletal class III malocclusion. J Oral Maxillofac Surg 71:1249-1260 https://doi.org/10.1016/j.joms.2013.01.002

피인용 문헌

  1. Botulinum Toxin Injection to Treat Masticatory Movement Disorder Corrected Mandibular Asymmetry in a Growing Patient : vol.30, pp.6, 2018, https://doi.org/10.1097/scs.0000000000005606
  2. Mandibular Bone Loss after Masticatory Muscles Intervention with Botulinum Toxin: An Approach from Basic Research to Clinical Findings vol.11, pp.2, 2019, https://doi.org/10.3390/toxins11020084
  3. Classification of the journal category "oral surgery" in the Scopus and the Science Citation Index Expanded: flaws and suggestions vol.45, pp.4, 2018, https://doi.org/10.5125/jkaoms.2019.45.4.186