Journal of The Korean Society of Emergency Medicine (대한응급의학회지)

The Korean Society of Emergency Medicine (대한응급의학회)
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Analysis of the association of serum potassium and lactic acid with neurologic outcome in out-of hospital post-cardiac arrest adult patients

자발순환 회복된 병원 외 성인 심정지 환자의 신경학적 예후와 혈청 칼륨 및 젖산 농도와의 관련성 분석

  • Lee, Yong Heon (Department of Emergency Medicine, Kangnam Sacred Heart Hospital, Hallym University College of Medicine) ;
  • Kim, Wonhee (Department of Emergency Medicine, Kangnam Sacred Heart Hospital, Hallym University College of Medicine) ;
  • Kang, Gu Hyun (Department of Emergency Medicine, Kangnam Sacred Heart Hospital, Hallym University College of Medicine) ;
  • Jang, Yong Soo (Department of Emergency Medicine, Kangnam Sacred Heart Hospital, Hallym University College of Medicine) ;
  • Choi, Hyun Young (Department of Emergency Medicine, Kangnam Sacred Heart Hospital, Hallym University College of Medicine) ;
  • Kim, Jae Guk (Department of Emergency Medicine, Kangnam Sacred Heart Hospital, Hallym University College of Medicine)
  • 이용헌 (한림대학교 강남성심병원 응급의학과) ;
  • 김원희 (한림대학교 강남성심병원 응급의학과) ;
  • 강구현 (한림대학교 강남성심병원 응급의학과) ;
  • 장용수 (한림대학교 강남성심병원 응급의학과) ;
  • 최현영 (한림대학교 강남성심병원 응급의학과) ;
  • 김재국 (한림대학교 강남성심병원 응급의학과)
  • Received : 2018.07.02
  • Accepted : 2018.08.28
  • Published : 2018.10.31

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Abstract

Objective: This study aimed to identify the effects of serum potassium and lactate on neurologic outcomes in out-of-hospital post-cardiac arrest adult patients. Methods: This study was a single center, retrospective observational study. We recruited out-of-hospital post-cardiac arrest adult patients admitted to an intensive care unit from 2011 to 2017. Primary outcome was good neurologic outcome at discharge. To evaluate the prognostic impact of serum potassium and lactate, univariate and multivariate logistic regression analyses were performed. Results: A total of 57 patients were included in this study. The number of patients with good neurologic outcome was 19 (33.3%). In the univariate analysis, good neurologic outcome patients showed a higher smoking rate, shorter pre-hospital transportation time, higher rate of percutaneous coronary intervention, and lower severity score (all P<0.05). The good neurologic outcome patients also presented higher pH, lower partial pressure of carbon dioxide, and lower potassium regarding laboratory findings on the first hospital day (all P<0.05). In the multivariate analysis, the independent factors favoring good neurologic outcome were pre-hospital transportation time (adjusted odds ratio [aOR], 0.82; 95% confidence interval [CI], 0.69-0.97; P=0.019) and lower partial pressure of carbon dioxide on the first hospital day (aOR, 0.95; 95% CI, 0.91-0.99; P=0.034). Conclusion: Serum potassium and lactate were not significantly associated with good neurologic outcome in out-of-hospital post-cardiac arrest adult patients. The prognostic factors for good neurologic outcome were pre-hospital transportation time and initial partial pressure of carbon dioxide.

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References

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