References
- Turecki G. The molecular bases of the suicidal brain. Nat Rev Neurosci 2014;15:802-16. https://doi.org/10.1038/nrn3839
- Turecki G, Brent DA. Suicide and suicidal behaviour. Lancet 2016;387:1227-39. https://doi.org/10.1016/S0140-6736(15)00234-2
- Turecki G. Preventing suicide: where are we? Lancet Psychiatry 2016;3:597-8. https://doi.org/10.1016/S2215-0366(16)30068-2
- O'Connor RC, Nock MK. The psychology of suicidal behaviour. Lancet Psychiatry 2014;1:73-85. https://doi.org/10.1016/S2215-0366(14)70222-6
- Mann JJ. Neurobiology of suicidal behaviour. Nat Rev Neurosci 2003;4:819-28.
- Moscicki EK. Gender differences in completed and attempted suicides. Ann Epidemiol 1994;4:152-8. https://doi.org/10.1016/1047-2797(94)90062-0
- Van Orden KA, Witte TK, Cukrowicz KC, Braithwaite SR, Selby EA, Joiner TE, Jr, et al. The interpersonal theory of suicide. Psychol Rev 2010;117:575-600. https://doi.org/10.1037/a0018697
- Brent DA. Risk factors for adolescent suicide and suicidal behavior: mental and substance abuse disorders, family environmental factors, and life stress. Suicide Life Threat Behav 1995;25 Suppl:52-63. https://doi.org/10.1111/j.1943-278X.1995.tb00490.x
- Kim CD, Seguin M, Therrien N, Riopel G, Chawky N, Lesage AD, et al. Familial aggregation of suicidal behavior: a family study of male suicide completers from the general population. Am J Psychiatry 2005;162:1017-9. https://doi.org/10.1176/appi.ajp.162.5.1017
- McGirr A, Alda M, Seguin M, Cabot S, Lesage A, Turecki G. Familial aggregation of suicide explained by cluster B traits: a three-group family study of suicide controlling for major depressive disorder. Am J Psychiatry 2009;166:1124-34. https://doi.org/10.1176/appi.ajp.2009.08111744
- Tidemalm D, Runeson B, Waern M, Frisell T, Carlstrom E, Lichtenstein P, et al. Familial clustering of suicide risk: a total population study of 11.4 million individuals. Psychol Med 2011;41:2527-34. https://doi.org/10.1017/S0033291711000833
- von Borczyskowski A, Lindblad F, Vinnerljung B, Reintjes R, Hjern A. Familial factors and suicide: an adoption study in a Swedish National Cohort. Psychol Med 2011;41:749-58. https://doi.org/10.1017/S0033291710001315
- Menke A, Domschke K, Czamara D, Klengel T, Hennings J, Lucae S, et al. Genome-wide association study of antidepressant treatment-emergent suicidal ideation. Neuropsychopharmacology 2012;37:797-807. https://doi.org/10.1038/npp.2011.257
- Perlis RH, Huang J, Purcell S, Fava M, Rush AJ, Sullivan PF, et al. Genome-wide association study of suicide attempts in mood disorder patients. Am J Psychiatry 2010;167:1499-507. https://doi.org/10.1176/appi.ajp.2010.10040541
- Galfalvy H, Zalsman G, Huang YY, Murphy L, Rosoklija G, Dwork AJ, et al. A pilot genome wide association and gene expression array study of suicide with and without major depression. World J Biol Psychiatry 2013;14:574-82. https://doi.org/10.3109/15622975.2011.597875
- Perroud N, Uher R, Ng MY, Guipponi M, Hauser J, Henigsberg N, et al. Genome-wide association study of increasing suicidal ideation during antidepressant treatment in the GENDEP project. Pharmacogenomics J 2012;12:68-77. https://doi.org/10.1038/tpj.2010.70
- Willour VL, Seifuddin F, Mahon PB, Jancic D, Pirooznia M, Steele J, et al. A genome-wide association study of attempted suicide. Mol Psychiatry 2012;17:433-44. https://doi.org/10.1038/mp.2011.4
- Perlis RH, Ruderfer D, Hamilton SP, Ernst C. Copy number variation in subjects with major depressive disorder who attempted suicide. PLoS One 2012;7:e46315. https://doi.org/10.1371/journal.pone.0046315
- Gilbert R, Widom CS, Browne K, Fergusson D, Webb E, Janson S. Burden and consequences of child maltreatment in high-income countries. Lancet 2009;373:68-81. https://doi.org/10.1016/S0140-6736(08)61706-7
- Fanous AH, Prescott CA, Kendler KS. The prediction of thoughts of death or self-harm in a population-based sample of female twins. Psychol Med 2004;34:301-12. https://doi.org/10.1017/S0033291703008857
- Brezo J, Paris J, Barker ED, Tremblay R, Vitaro F, Zoccolillo M, et al. Natural history of suicidal behaviors in a population-based sample of young adults. Psychol Med 2007;37:1563-74. https://doi.org/10.1017/S003329170700058X
- Lopez-Castroman J, Melhem N, Birmaher B, Greenhill L, Kolko D, Stanley B, et al. Early childhood sexual abuse increases suicidal intent. World Psychiatry 2013;12:149-54. https://doi.org/10.1002/wps.20039
- Brezo J, Paris J, Vitaro F, Hebert M, Tremblay RE, Turecki G. Predicting suicide attempts in young adults with histories of childhood abuse. Br J Psychiatry 2008;193:134-9. https://doi.org/10.1192/bjp.bp.107.037994
- Fergusson DM, Woodward LJ, Horwood LJ. Risk factors and life processes associated with the onset of suicidal behaviour during adolescence and early adulthood. Psychol Med 2000;30:23-39. https://doi.org/10.1017/S003329179900135X
- Angst J, Degonda M, Ernst C. The Zurich Study: XV. Suicide attempts in a cohort from age 20 to 30. Eur Arch Psychiatry Clin Neurosci 1992;242:135-41. https://doi.org/10.1007/BF02191561
- Hertzman C. Putting the concept of biological embedding in historical perspective. Proc Natl Acad Sci U S A 2012;109 Suppl 2:17160-7. https://doi.org/10.1073/pnas.1202203109
- Heim C, Shugart M, Craighead WE, Nemeroff CB. Neurobiological and psychiatric consequences of child abuse and neglect. Dev Psychobiol 2010;52:671-90. https://doi.org/10.1002/dev.20494
- McGowan PO, Sasaki A, D'Alessio AC, Dymov S, Labonte B, Szyf M, et al. Epigenetic regulation of the glucocorticoid receptor in human brain associates with childhood abuse. Nat Neurosci 2009;12:342-8. https://doi.org/10.1038/nn.2270
- Binder EB, Bradley RG, Liu W, Epstein MP, Deveau TC, Mercer KB, et al. Association of FKBP5 polymorphisms and childhood abuse with risk of posttraumatic stress disorder symptoms in adults. JAMA 2008;299:1291-305. https://doi.org/10.1001/jama.299.11.1291
- Supriyanto I, Sasada T, Fukutake M, Asano M, Ueno Y, Nagasaki Y, et al. Association of FKBP5 gene haplotypes with completed suicide in the Japanese population. Prog Neuropsychopharmacol Biol Psychiatry 2011;35:252-6. https://doi.org/10.1016/j.pnpbp.2010.11.019
- Labonte B, Suderman M, Maussion G, Lopez JP, Navarro-Sanchez L, Yerko V, et al. Genome-wide methylation changes in the brains of suicide completers. Am J Psychiatry 2013;170:511-20. https://doi.org/10.1176/appi.ajp.2012.12050627
- Weder N, Zhang H, Jensen K, Yang BZ, Simen A, Jackowski A, et al. Child abuse, depression, and methylation in genes involved with stress, neural plasticity, and brain circuitry. J Am Acad Child Adolesc Psychiatry 2014;53:417-24 e5. https://doi.org/10.1016/j.jaac.2013.12.025
- Roth TL, Lubin FD, Funk AJ, Sweatt JD. Lasting epigenetic influence of early-life adversity on the BDNF gene. Biol Psychiatry 2009;65:760-9. https://doi.org/10.1016/j.biopsych.2008.11.028
- Roth TL, Zoladz PR, Sweatt JD, Diamond DM. Epigenetic modification of hippocampal Bdnf DNA in adult rats in an animal model of post-traumatic stress disorder. J Psychiatr Res 2011;45:919-26. https://doi.org/10.1016/j.jpsychires.2011.01.013
- Dwivedi Y, Rizavi HS, Conley RR, Roberts RC, Tamminga CA, Pandey GN. Altered gene expression of brain-derived neurotrophic factor and receptor tyrosine kinase B in postmortem brain of suicide subjects. Arch Gen Psychiatry 2003;60:804-15. https://doi.org/10.1001/archpsyc.60.8.804
- Pandey GN, Ren X, Rizavi HS, Conley RR, Roberts RC, Dwivedi Y. Brain-derived neurotrophic factor and tyrosine kinase B receptor signalling in post-mortem brain of teenage suicide victims. Int J Neuropsychopharmacol 2008;11:1047-61. https://doi.org/10.1017/S1461145708009000
- Ernst C, Deleva V, Deng X, Sequeira A, Pomarenski A, Klempan T, et al. Alternative splicing, methylation state, and expression profile of tropomyosin-related kinase B in the frontal cortex of suicide completers. Arch Gen Psychiatry 2009;66:22-32. https://doi.org/10.1001/archpsyc.66.1.22
- Keller S, Sarchiapone M, Zarrilli F, Videtic A, Ferraro A, Carli V, et al. Increased BDNF promoter methylation in the Wernicke area of suicide subjects. Arch Gen Psychiatry 2010;67:258-67. https://doi.org/10.1001/archgenpsychiatry.2010.9
- Banerjee R, Ghosh AK, Ghosh B, Bhattacharyya S, Mondal AC. Decreased mRNA and Protein Expression of BDNF, NGF, and their Receptors in the Hippocampus from Suicide: An Analysis in Human Postmortem Brain. Clin Med Insights Pathol 2013;6:1-11.
- Fuchikami M, Morinobu S, Segawa M, Okamoto Y, Yamawaki S, Ozaki N, et al. DNA methylation profiles of the brain-derived neurotrophic factor(BDNF) gene as a potent diagnostic biomarker in major depression. PLoS One 2011;6:e23881. https://doi.org/10.1371/journal.pone.0023881
- Kim JM, Kang HJ, Bae KY, Kim SW, Shin IS, Kim HR, et al. Association of BDNF promoter methylation and genotype with suicidal ideation in elderly Koreans. Am J Geriatr Psychiatry 2014;22:989-96. https://doi.org/10.1016/j.jagp.2014.02.011
- Zhang X, Yazaki J, Sundaresan A, Cokus S, Chan SW, Chen H, et al. Genome-wide high-resolution mapping and functional analysis of DNA methylation in arabidopsis. Cell 2006;126:1189-201. https://doi.org/10.1016/j.cell.2006.08.003
- Ziller MJ, Gu H, Muller F, Donaghey J, Tsai LT, Kohlbacher O, et al. Charting a dynamic DNA methylation landscape of the human genome. Nature 2013;500:477-81. https://doi.org/10.1038/nature12433
- Schroeder M, Hillemacher T, Bleich S, Frieling H. The epigenetic code in depression: implications for treatment. Clinical Pharmacology & Therapeutics 2012;91: 310-4. https://doi.org/10.1038/clpt.2011.282
- Turecki G, Ota VK, Belangero SI, Jackowski A, Kaufman J. Early life adversity, genomic plasticity, and psychopathology. Lancet Psychiatry 2014;1:461-6. https://doi.org/10.1016/S2215-0366(14)00022-4
- Brent DA, Bridge J, Johnson BA, Connolly J. Suicidal behavior runs in families. A controlled family study of adolescent suicide victims. Arch Gen Psychiatry 1996;53:1145-52. https://doi.org/10.1001/archpsyc.1996.01830120085015
- Courtet P, Gottesman, II, Jollant F, Gould TD. The neuroscience of suicidal behaviors: what can we expect from endophenotype strategies? Transl Psychiatry 2011;1.
- Brezo J, Barker ED, Paris J, Hebert M, Vitaro F, Tremblay RE, et al. Childhood trajectories of anxiousness and disruptiveness as predictors of suicide attempts. Arch Pediatr Adolesc Med 2008;162:1015-21. https://doi.org/10.1001/archpedi.162.11.1015
- Dumais A, Lesage AD, Alda M, Rouleau G, Dumont M, Chawky N, et al. Risk factors for suicide completion in major depression: a case-control study of impulsive and aggressive behaviors in men. Am J Psychiatry 2005;162:2116-24. https://doi.org/10.1176/appi.ajp.162.11.2116
- Arsenault-Lapierre G, Kim C, Turecki G. Psychiatric diagnoses in 3275 suicides: a meta-analysis. BMC Psychiatry 2004;4:37. https://doi.org/10.1186/1471-244X-4-37
- Rucker JJ, Breen G, Pinto D, Pedroso I, Lewis CM, Cohen-Woods S, et al. Genome-wide association analysis of copy number variation in recurrent depressive disorder. Mol Psychiatry 2013;18:183-9. https://doi.org/10.1038/mp.2011.144
- Kim C, Lesage A, Seguin M, Chawky N, Vanier C, Lipp O, et al. Patterns of co-morbidity in male suicide completers. Psychol Med 2003;33:1299-309. https://doi.org/10.1017/S0033291703008146
- Seguin M, Lesage A, Turecki G, Bouchard M, Chawky N, Tremblay N, et al. Life trajectories and burden of adversity: mapping the developmental profiles of suicide mortality. Psychol Med 2007;37:1575-83. https://doi.org/10.1017/S0033291707000955
- Chachamovich E, Ding Y, Turecki G. Levels of aggressiveness are higher among alcohol-related suicides: results from a psychological autopsy study. Alcohol 2012;46:529-36. https://doi.org/10.1016/j.alcohol.2012.03.007
- Coccaro EF, Siever LJ, Klar HM, Maurer G, Cochrane K, Cooper TB, et al. Serotonergic studies in patients with affective and personality disorders. Correlates with suicidal and impulsive aggressive behavior. Arch Gen Psychiatry 1989;46:587-99. https://doi.org/10.1001/archpsyc.1989.01810070013002
- Freemantle E, Chen GG, Cruceanu C, Mechawar N, Turecki G. Analysis of oxysterols and cholesterol in prefrontal cortex of suicides. Int J Neuropsychopharmacol 2013;16:1241-9. https://doi.org/10.1017/S1461145712001587
- Lalovic A, Levy E, Luheshi G, Canetti L, Grenier E, Sequeira A, et al. Cholesterol content in brains of suicide completers. Int J Neuropsychopharmacol 2007;10:159-66. https://doi.org/10.1017/S1461145706006663
- Ernst C, Mechawar N, Turecki G. Suicide neurobiology. Prog Neurobiol 2009;89:315-33. https://doi.org/10.1016/j.pneurobio.2009.09.001
- Qin P, Agerbo E, Mortensen PB. Suicide risk in relation to family history of completed suicide and psychiatric disorders: a nested case-control study based on longitudinal registers. Lancet 2002;360:1126-30. https://doi.org/10.1016/S0140-6736(02)11197-4
- Asberg M, Thoren P, Traskman L, Bertilsson L, Ringberger V. "Serotonin depression"--a biochemical subgroup within the affective disorders? Science 1976;191:478-80.
- Stanley M, Virgilio J, Gershon S. Tritiated imipramine binding sites are decreased in the frontal cortex of suicides. Science 1982;216:1337-9. https://doi.org/10.1126/science.7079769
- Stanley M, Mann JJ. Increased serotonin-2 binding sites in frontal cortex of suicide victims. Lancet 1983;1:214-6.
- Mann JJ. The serotonergic system in mood disorders and suicidal behaviour. Philos Trans R Soc Lond B Biol Sci 2013;368:20120537. https://doi.org/10.1098/rstb.2012.0537
- Parsey RV, Oquendo MA, Ogden RT, Olvet DM, Simpson N, Huang YY, et al. Altered serotonin 1A binding in major depression: a [carbonyl-C-11]WAY100635 positron emission tomography study. Biol Psychiatry 2006;59:106-13. https://doi.org/10.1016/j.biopsych.2005.06.016
- Arango V, Underwood MD, Boldrini M, Tamir H, Kassir SA, Hsiung S, et al. Serotonin 1A receptors, serotonin transporter binding and serotonin transporter mRNA expression in the brainstem of depressed suicide victims. Neuropsychopharmacology 2001;25:892-903. https://doi.org/10.1016/S0893-133X(01)00310-4
- Miller JM, Hesselgrave N, Ogden RT, Sullivan GM, Oquendo MA, Mann JJ, et al. Positron emission tomography quantification of serotonin transporter in suicide attempters with major depressive disorder. Biol Psychiatry 2013;74:287-95. https://doi.org/10.1016/j.biopsych.2013.01.024
- Yanowitch R, Coccaro EF. The neurochemistry of human aggression. Adv Genet 2011;75:151-69.
- Brezo J, Bureau A, Merette C, Jomphe V, Barker ED, Vitaro F, et al. Differences and similarities in the serotonergic diathesis for suicide attempts and mood disorders: a 22-year longitudinal gene-environment study. Mol Psychiatry 2010;15:831-43. https://doi.org/10.1038/mp.2009.19
- Smith KA, Fairburn CG, Cowen PJ. Relapse of depression after rapid depletion of tryptophan. Lancet 1997;349:915-9. https://doi.org/10.1016/S0140-6736(96)07044-4
- Benkelfat C, Ellenbogen MA, Dean P, Palmour RM, Young SN. Mood-lowering effect of tryptophan depletion. Enhanced susceptibility in young men at genetic risk for major affective disorders. Arch Gen Psychiatry 1994;51:687-97. https://doi.org/10.1001/archpsyc.1994.03950090019003
- Arango V, Underwood MD, Mann JJ. Fewer pigmented locus coeruleus neurons in suicide victims: preliminary results. Biol Psychiatry 1996;39:112-20. https://doi.org/10.1016/0006-3223(95)00107-7
- Galfalvy H, Currier D, Oquendo MA, Sullivan G, Huang YY, John Mann J. Lower CSF MHPG predicts short-term risk for suicide attempt. Int J Neuropsychopharmacol 2009;12:1327-35. https://doi.org/10.1017/S1461145709990228
- van Heeringen K, Mann JJ. The neurobiology of suicide. Lancet Psychiatry 2014;1:63-72. https://doi.org/10.1016/S2215-0366(14)70220-2
- Choudary PV, Molnar M, Evans SJ, Tomita H, Li JZ, Vawter MP, et al. Altered cortical glutamatergic and GABAergic signal transmission with glial involvement in depression. Proc Natl Acad Sci U S A 2005;102:15653-8. https://doi.org/10.1073/pnas.0507901102
- Sequeira A, Mamdani F, Ernst C, Vawter MP, Bunney WE, Lebel V, et al. Global brain gene expression analysis links glutamatergic and GABAergic alterations to suicide and major depression. PLoS One 2009;4:e6585. https://doi.org/10.1371/journal.pone.0006585
- Larkin GL, Beautrais AL. A preliminary naturalistic study of low-dose ketamine for depression and suicide ideation in the emergency department. Int J Neuropsychopharmacol 2011;14:1127-31. https://doi.org/10.1017/S1461145711000629
- Price RB, Iosifescu DV, Murrough JW, Chang LC, Al Jurdi RK, Iqbal SZ, et al. Effects of ketamine on explicit and implicit suicidal cognition: a randomized controlled trial in treatment-resistant depression. Depress Anxiety 2014;31:335-43. https://doi.org/10.1002/da.22253
- Gilad GM, Gilad VH. Overview of the brain polyaminestress-response: regulation, development, and modulation by lithium and role in cell survival. Cell Mol Neurobiol 2003;23:637-49. https://doi.org/10.1023/A:1025036532672
- Hayashi Y, Tanaka J, Morizumi Y, Kitamura Y, Hattori Y. Polyamine levels in brain and plasma after acute restraint or water-immersion restraint stress in mice. Neurosci Lett 2004;355:57-60. https://doi.org/10.1016/j.neulet.2003.10.027
- Doyle KM, Kirby BP, Murphy D, Shaw GG. Effect of Ltype calcium channel antagonists on spermine-induced CNS excitation in vivo. Neurosci Lett 2005;380:247-51. https://doi.org/10.1016/j.neulet.2005.01.052
- Sequeira A, Gwadry FG, Ffrench-Mullen JM, Canetti L, Gingras Y, Casero RA, Jr, et al. Implication of SSAT by gene expression and genetic variation in suicide and major depression. Arch Gen Psychiatry 2006;63:35-48. https://doi.org/10.1001/archpsyc.63.1.35
- Fiori LM, Bureau A, Labbe A, Croteau J, Noel S, Merette C, et al. Global gene expression profiling of the polyamine system in suicide completers. Int J Neuropsychopharmacol 2011;14:595-605. https://doi.org/10.1017/S1461145710001574
- Klempan TA, Rujescu D, Merette C, Himmelman C, Sequeira A, Canetti L, et al. Profiling brain expression of the spermidine/spermine N1-acetyltransferase 1(SAT1) gene in suicide. Am J Med Genet B Neuropsychiatr Genet 2009;150B:934-43. https://doi.org/10.1002/ajmg.b.30920
- Chen GG, Fiori LM, Moquin L, Gratton A, Mamer O, Mechawar N, et al. Evidence of altered polyamine concentrations in cerebral cortex of suicide completers. Neuropsychopharmacology 2010;35:1477-84. https://doi.org/10.1038/npp.2010.17
- Guipponi M, Deutsch S, Kohler K, Perroud N, Le Gal F, Vessaz M, et al. Genetic and epigenetic analysis of SSAT gene dysregulation in suicidal behavior. Am J Med Genet B Neuropsychiatr Genet 2009;150B:799-807. https://doi.org/10.1002/ajmg.b.30901
- Le-Niculescu H, Levey DF, Ayalew M, Palmer L, Gavrin LM, Jain N, et al. Discovery and validation of blood biomarkers for suicidality. Mol Psychiatry 2013;18:1249-64. https://doi.org/10.1038/mp.2013.95
- Dahel KA, Al-Saffar NM, Flayeh KA. Polyamine oxidase activity in sera of depressed and schizophrenic patients after ECT treatment. Neurochem Res 2001;26:415-8. https://doi.org/10.1023/A:1010959300545
- Engelberg H. Low serum cholesterol and suicide. Lancet 1992;339:727-9. https://doi.org/10.1016/0140-6736(92)90609-7
- Wu S, Ding Y, Wu F, Xie G, Hou J, Mao P. Serum lipid levels and suicidality: a meta-analysis of 65 epidemiological studies. J Psychiatry Neurosci 2016;41:56-69. https://doi.org/10.1503/jpn.150079
- De Berardis D, Marini S, Piersanti M, Cavuto M, Perna G, Valchera A, et al. The Relationships between Cholesterol and Suicide: An Update. ISRN Psychiatry 2012;2012:387901.
- Serafini G, Pompili M, Elena Seretti M, Stefani H, Palermo M, Coryell W, et al. The role of inflammatory cytokines in suicidal behavior: a systematic review. Eur Neuropsychopharmacol 2013;23:1672-86. https://doi.org/10.1016/j.euroneuro.2013.06.002
- Isung J, Aeinehband S, Mobarrez F, Martensson B, Nordstrom P, Asberg M, et al. Low vascular endothelial growth factor and interleukin-8 in cerebrospinal fluid of suicide attempters. Transl Psychiatry 2012;2:e196. https://doi.org/10.1038/tp.2012.123
- Erhardt S, Lim CK, Linderholm KR, Janelidze S, Lindqvist D, Samuelsson M, et al. Connecting inflammation with glutamate agonism in suicidality. Neuropsychopharmacology 2013;38:743-52. https://doi.org/10.1038/npp.2012.248
- Sublette ME, Galfalvy HC, Fuchs D, Lapidus M, Grunebaum MF, Oquendo MA, et al. Plasma kynurenine levels are elevated in suicide attempters with major depressive disorder. Brain Behav Immun 2011;25:1272-8. https://doi.org/10.1016/j.bbi.2011.05.002
- Carlborg A, Jokinen J, Jonsson EG, Erhardt S, Nordstrom P. CSF kynurenic acid and suicide risk in schizophrenia spectrum psychosis. Psychiatry Res 2013;205:165-7. https://doi.org/10.1016/j.psychres.2012.08.021
- Bay-Richter C, Linderholm KR, Lim CK, Samuelsson M, Traskman-Bendz L, Guillemin GJ, et al. A role for inflammatory metabolites as modulators of the glutamate N-methyl-D-aspartate receptor in depression and suicidality. Brain Behav Immun 2015;43:110-7. https://doi.org/10.1016/j.bbi.2014.07.012
- Pandey GN, Rizavi HS, Ren X, Fareed J, Hoppensteadt DA, Roberts RC, et al. Proinflammatory cytokines in the prefrontal cortex of teenage suicide victims. J Psychiatr Res 2012;46:57-63. https://doi.org/10.1016/j.jpsychires.2011.08.006
- Tonelli LH, Stiller J, Rujescu D, Giegling I, Schneider B, Maurer K, et al. Elevated cytokine expression in the orbitofrontal cortex of victims of suicide. Acta Psychiatr Scand 2008;117:198-206. https://doi.org/10.1111/j.1600-0447.2007.01128.x
- Torres-Platas SG, Cruceanu C, Chen GG, Turecki G, Mechawar N. Evidence for increased microglial priming and macrophage recruitment in the dorsal anterior cingulate white matter of depressed suicides. Brain Behav Immun 2014;42:50-9. https://doi.org/10.1016/j.bbi.2014.05.007
- Steiner J, Bielau H, Brisch R, Danos P, Ullrich O, Mawrin C, et al. Immunological aspects in the neurobiology of suicide: elevated microglial density in schizophrenia and depression is associated with suicide. J Psychiatr Res 2008;42:151-7. https://doi.org/10.1016/j.jpsychires.2006.10.013
- Ehlert U. Enduring psychobiological effects of childhood adversity. Psychoneuroendocrinology 2013;38:1850-7. https://doi.org/10.1016/j.psyneuen.2013.06.007
- Danese A, Moffitt TE, Pariante CM, Ambler A, Poulton R, Caspi A. Elevated inflammation levels in depressed adults with a history of childhood maltreatment. Arch Gen Psychiatry 2008;65:409-15. https://doi.org/10.1001/archpsyc.65.4.409
- Rajkowska G. Postmortem studies in mood disorders indicate altered numbers of neurons and glial cells. Biol Psychiatry 2000;48:766-77. https://doi.org/10.1016/S0006-3223(00)00950-1
- Torres-Platas SG, Hercher C, Davoli MA, Maussion G, Labonte B, Turecki G, et al. Astrocytic hypertrophy in anterior cingulate white matter of depressed suicides. Neuropsychopharmacology 2011;36:2650-8. https://doi.org/10.1038/npp.2011.154
- Ernst C, Nagy C, Kim S, Yang JP, Deng X, Hellstrom IC, et al. Dysfunction of astrocyte connexins 30 and 43 in dorsal lateral prefrontal cortex of suicide completers. Biol Psychiatry 2011;70:312-9. https://doi.org/10.1016/j.biopsych.2011.03.038
- Bernard R, Kerman IA, Thompson RC, Jones EG, Bunney WE, Barchas JD, et al. Altered expression of glutamate signaling, growth factor, and glia genes in the locus coeruleus of patients with major depression. Mol Psychiatry 2011;16:634-46. https://doi.org/10.1038/mp.2010.44
- Rose CR, Blum R, Pichler B, Lepier A, Kafitz KW, Konnerth A. Truncated TrkB-T1 mediates neurotrophin-evoked calcium signalling in glia cells. Nature 2003;426:74-8. https://doi.org/10.1038/nature01983
- Razzoli M, Domenici E, Carboni L, Rantamaki T, Lindholm J, Castren E, et al. A role for BDNF/TrkB signaling in behavioral and physiological consequences of social defeat stress. Genes Brain Behav 2011;10:424-33. https://doi.org/10.1111/j.1601-183X.2011.00681.x
- Roy A. Hypothalamic-pituitary-adrenal axis function and suicidal behavior in depression. Biol Psychiatry 1992;32:812-6. https://doi.org/10.1016/0006-3223(92)90084-D
- Coryell W, Schlesser M. The dexamethasone suppression test and suicide prediction. Am J Psychiatry 2001;158:748-53. https://doi.org/10.1176/appi.ajp.158.5.748
- Pfeffer CR, Stokes P, Shindledecker R. Suicidal behavior and hypothalamic-pituitary-adrenocortical axis indices in child psychiatric inpatients. Biol Psychiatry 1991;29:909-17. https://doi.org/10.1016/0006-3223(91)90057-S
- Raadsheer FC, van Heerikhuize JJ, Lucassen PJ, Hoogendijk WJ, Tilders FJ, Swaab DF. Corticotropin-releasing hormone mRNA levels in the paraventricular nucleus of patients with Alzheimer's disease and depression. Am J Psychiatry 1995;152:1372-6. https://doi.org/10.1176/ajp.152.9.1372
- Raadsheer FC, Hoogendijk WJ, Stam FC, Tilders FJ, Swaab DF. Increased numbers of corticotropin-releasing hormone expressing neurons in the hypothalamic paraventricular nucleus of depressed patients. Neuroendocrinology 1994;60:436-44. https://doi.org/10.1159/000126778
- Wang SS, Kamphuis W, Huitinga I, Zhou JN, Swaab DF. Gene expression analysis in the human hypothalamus in depression by laser microdissection and realtime PCR: the presence of multiple receptor imbalances. Mol Psychiatry 2008;13:786-99, 41. https://doi.org/10.1038/mp.2008.38
- Nemeroff CB, Widerlov E, Bissette G, Walleus H, Karlsson I, Eklund K, et al. Elevated concentrations of CSF corticotropin-releasing factor-like immunoreactivity in depressed patients. Science 1984;226:1342-4. https://doi.org/10.1126/science.6334362
- Nemeroff CB, Owens MJ, Bissette G, Andorn AC, Stanley M. Reduced corticotropin releasing factor binding sites in the frontal cortex of suicide victims. Arch Gen Psychiatry 1988;45:577-9. https://doi.org/10.1001/archpsyc.1988.01800300075009
- Lopez JF, Palkovits M, Arato M, Mansour A, Akil H, Watson SJ. Localization and quantification of proopiomelanocortin mRNA and glucocorticoid receptor mRNA in pituitaries of suicide victims. Neuroendocrinology 1992;56:491-501. https://doi.org/10.1159/000126266
- Dumser T, Barocka A, Schubert E. Weight of adrenal glands may be increased in persons who commit suicide. Am J Forensic Med Pathol 1998;19:72-6. https://doi.org/10.1097/00000433-199803000-00014
- Szigethy E, Conwell Y, Forbes NT, Cox C, Caine ED. Adrenal weight and morphology in victims of completed suicide. Biol Psychiatry 1994;36:374-80. https://doi.org/10.1016/0006-3223(94)91212-2
- McGirr A, Diaconu G, Berlim MT, Pruessner JC, Sable R, Cabot S, et al. Dysregulation of the sympathetic nervous system, hypothalamic-pituitary-adrenal axis and executive function in individuals at risk for suicide. J Psychiatry Neurosci 2010;35:399-408. https://doi.org/10.1503/jpn.090121
- Oquendo MA, Placidi GP, Malone KM, Campbell C, Keilp J, Brodsky B, et al. Positron emission tomography of regional brain metabolic responses to a serotonergic challenge and lethality of suicide attempts in major depression. Arch Gen Psychiatry 2003;60:14-22. https://doi.org/10.1001/archpsyc.60.1.14
- Leyton M, Paquette V, Gravel P, Rosa-Neto P, Weston F, Diksic M, et al. alpha-[11C]Methyl-L-tryptophan trapping in the orbital and ventral medial prefrontal cortex of suicide attempters. Eur Neuropsychopharmacol 2006;16:220-3. https://doi.org/10.1016/j.euroneuro.2005.09.006
- van Heeringen K, Van den Abbeele D, Vervaet M, Soenen L, Audenaert K. The functional neuroanatomy of mental pain in depression. Psychiatry Res 2010;181:141-4. https://doi.org/10.1016/j.pscychresns.2009.07.011
- Oquendo MA, Galfalvy H, Sullivan GM, Miller JM, Milak MM, Sublette ME, et al. Positron Emission Tomographic Imaging of the Serotonergic System and Prediction of Risk and Lethality of Future Suicidal Behavior. JAMA Psychiatry 2016;73:1048-55. https://doi.org/10.1001/jamapsychiatry.2016.1478
- van Heeringen C, Bijttebier S, Godfrin K. Suicidal brains: a review of functional and structural brain studies in association with suicidal behaviour. Neurosci Biobehav Rev 2011;35:688-98. https://doi.org/10.1016/j.neubiorev.2010.08.007
- Tanaka SC, Doya K, Okada G, Ueda K, Okamoto Y, Yamawaki S. Prediction of immediate and future rewards differentially recruits cortico-basal ganglia loops. Nat Neurosci 2004;7:887-93. https://doi.org/10.1038/nn1279
- Richard-Devantoy S, Berlim MT, Jollant F. A metaanalysis of neuropsychological markers of vulnerability to suicidal behavior in mood disorders. Psychol Med 2014;44:1663-73. https://doi.org/10.1017/S0033291713002304
- Jollant F, Lawrence NS, Giampietro V, Brammer MJ, Fullana MA, Drapier D, et al. Orbitofrontal cortex response to angry faces in men with histories of suicide attempts. Am J Psychiatry 2008;165:740-8. https://doi.org/10.1176/appi.ajp.2008.07081239
- Pan L, Segreti A, Almeida J, Jollant F, Lawrence N, Brent D, et al. Preserved hippocampal function during learning in the context of risk in adolescent suicide attempt. Psychiatry Res 2013;211:112-8. https://doi.org/10.1016/j.pscychresns.2012.07.008
- Willeumier K, Taylor DV, Amen DG. Decreased cerebral blood flow in the limbic and prefrontal cortex using SPECT imaging in a cohort of completed suicides. Transl Psychiatry 2011;1:e28. https://doi.org/10.1038/tp.2011.28
- Jollant F, Lawrence NS, Olie E, O'Daly O, Malafosse A, Courtet P, et al. Decreased activation of lateral orbitofrontal cortex during risky choices under uncertainty is associated with disadvantageous decision-making and suicidal behavior. Neuroimage 2010;51:1275-81. https://doi.org/10.1016/j.neuroimage.2010.03.027
- Pan LA, Batezati-Alves SC, Almeida JR, Segreti A, Akkal D, Hassel S, et al. Dissociable patterns of neural activity during response inhibition in depressed adolescents with and without suicidal behavior. J Am Acad Child Adolesc Psychiatry 2011;50:602-11e3. https://doi.org/10.1016/j.jaac.2011.03.018