대한치매학회지 (Dementia and Neurocognitive Disorders)

대한치매학회 (Korean Dementia Association)
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18F-THK5351 PET Imaging in the Behavioral Variant of Frontotemporal Dementia

  • Nam, Gijin (College of Medicine, Gachon University) ;
  • Jeong, Hye Jin (Neuroscience Research Institute, Gachon University) ;
  • Kang, Jae Myeong (Department of Psychiatry, Gachon University Gil Medical Center, Gachon University College of Medicine) ;
  • Lee, Sang-Yoon (Department of Neuroscience, Gachon University College of Medicine) ;
  • Seo, Seongho (Department of Psychiatry, Gachon University Gil Medical Center, Gachon University College of Medicine) ;
  • Seo, Ha-Eun (Neuroscience Research Institute, Gachon University) ;
  • Park, Kee Hyung (Department of Neurology, Gachon University Gil Medical Center, Gachon University College of Medicine) ;
  • Yeon, Byeong Kil (Department of Psychiatry, Gachon University Gil Medical Center, Gachon University College of Medicine) ;
  • Ido, Tatsuo (Neuroscience Research Institute, Gachon University) ;
  • Shin, Dong Jin (Department of Neurology, Gachon University Gil Medical Center, Gachon University College of Medicine) ;
  • Noh, Young (Department of Neurology, Gachon University Gil Medical Center, Gachon University College of Medicine)
  • 투고 : 2018.12.09
  • 심사 : 2018.12.31
  • 발행 : 2018.12.31
⟨ 이전 논문 다음 논문 ⟩

초록

Background and Purpose: Behavioral variant frontotemporal dementia (bvFTD) is a subtype of frontotemporal dementia, which has clinical symptoms of progressive personality and behavioral changes with deterioration of social cognition and executive functions. The pathology of bvFTD is known to be tauopathy or TDP-43 equally. We analyzed the $^{18}F-THK5351$ positron emission tomography (PET) scans, which were recently developed tau PET, in patients with clinically-diagnosed bvFTD. Methods: Forty-eight participants, including participants with behavioral variant frontotemporal dementia (bvFTD, n=3), Alzheimer's disease (AD, n=21) and normal cognition (NC, n=24) who completed 3T magnetic resonance images, $^{18}F-THK5351$ PET scans, and detailed neuropsychological tests were included in the study. Voxel-wise statistical analysis and region of interest (ROI)-based analyses were performed to evaluate the retention of THK in bvFTD patients. Results: In the voxel-based and ROI-based analyses, patients with bvFTD showed greater THK retention in the prefrontal, medial frontal, orbitofrontal, anterior cingulate, insula, anterior inferior temporal and striatum regions compared to NC participants. Left-right asymmetry was noted in the bvFTD patients. A patient with extrapyramidal symptoms showed much greater THK retention in the brainstem. Conclusions: The distribution of THK retention in the bvFTD patients was mainly in the frontal, insula, anterior temporal, and striatum regions which are known to be the brain regions corresponding to the clinical symptoms of bvFTD. Our study suggests that $^{18}F-THK5351$ PET imaging could be a supportive tool for diagnosis of bvFTD.

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과제정보

연구 과제 주관 기관 : Korea Health Industry Development Institute (KHIDI)

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피인용 문헌

  1. Crossing Borders Between Frontotemporal Dementia and Psychiatric Disorders: An Updated Overview vol.75, pp.2, 2018, https://doi.org/10.3233/jad-191333