DOI QR코드

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Association of Alzheimer's Disease with the Risk of Developing Epilepsy: a 10-Year Nationwide Cohort Study

  • Lyou, Hyun Ji (Department of Neurology, National Health Insurance Service Ilsan Hospital) ;
  • Seo, Kwon-Duk (Department of Neurology, National Health Insurance Service Ilsan Hospital) ;
  • Lee, Ji Eun (Department of Neurology, National Health Insurance Service Ilsan Hospital) ;
  • Pak, Hae Yong (Research Analysis Team, National Health Insurance Service Ilsan Hospial) ;
  • Lee, Jun Hong (Department of Neurology, National Health Insurance Service Ilsan Hospital)
  • 투고 : 2018.12.06
  • 심사 : 2018.12.31
  • 발행 : 2018.12.31

초록

Background and Purpose: Previous studies have reported conflicting results about the prevalence of seizures in Alzheimer's disease (AD). There are few epidemiological studies on this topic in Asia. Thus, the objective of this study was to examine demographic and clinical characteristics as well as incidence for seizures in AD patients compared to non-AD patients in a prospective, longitudinal, community-based cohort with a long follow-up. Methods: Data were collected from National Health Insurance Service-National Elderly Cohort (NHIS-elderly) Database to define patients with AD from 2004-2006 using Korean Classification Diseases codes G30 and F00. We performed a 1:5 case-control propensity score matching based on age, sex, and household income. We conducted Cox proportional hazards regression analysis to estimate the risk of epilepsy in AD patients. Results: In the cohort study, patients with AD had higher risk for epilepsy than those without AD, with hazard ratio of 2.773 (95% confidence interval [CI], 2.515-3.057). This study also showed that male gender and comorbidities such as hypertension, hyperlipidemia, diabetes, and chronic kidney disease increased the risk of developing epilepsy. Patients with AD had 1.527 (95% CI, 1.375-1.695) times higher mortality rate than those in the control group. Conclusions: AD patients have significantly higher risk of developing epilepsy than non-AD patients.

키워드

참고문헌

  1. Vu LC, Piccenna L, Kwan P, O'Brien TJ. New-onset epilepsy in the elderly. Br J Clin Pharmacol 2018;84:2208-2217. https://doi.org/10.1111/bcp.13653
  2. Stephen LJ, Brodie MJ. Epilepsy in elderly people. Lancet 2000;355:1441-1446. https://doi.org/10.1016/S0140-6736(00)02149-8
  3. Stefan H. Epilepsy in the elderly: facts and challenges. Acta Neurol Scand 2011;124:223-237. https://doi.org/10.1111/j.1600-0404.2010.01464.x
  4. Ghosh S, Jehi LE. New-onset epilepsy in the elderly: challenges for the internist. Cleve Clin J Med 2014;81:490-498. https://doi.org/10.3949/ccjm.81a.13148
  5. Committee on Epidemiology of Korean Epilepsy Society. Epidemiological Study of Seizure and Epilepsy using Nationwide Database for Corean Epilepsy Patients. Seoul: Korean Epilepsy Society; 2013.
  6. Pandis D, Scarmeas N. Seizures in Alzheimer disease: clinical and epidemiological data. Epilepsy Curr 2012;12:184-187. https://doi.org/10.5698/1535-7511-12.5.184
  7. Hauser WA, Morris ML, Heston LL, Anderson VE. Seizures and myoclonus in patients with Alzheimer's disease. Neurology 1986;36:1226-1230. https://doi.org/10.1212/WNL.36.9.1226
  8. Hauser WA, Annegers JF, Kurland LT. Incidence of epilepsy and unprovoked seizures in Rochester, Minnesota: 1935-1984. Epilepsia 1993;34:453-468. https://doi.org/10.1111/j.1528-1157.1993.tb02586.x
  9. Friedman D, Honig LS, Scarmeas N. Seizures and epilepsy in Alzheimer's disease. CNS Neurosci Ther 2012;18:285-294. https://doi.org/10.1111/j.1755-5949.2011.00251.x
  10. Sherzai D, Losey T, Vega S, Sherzai A. Seizures and dementia in the elderly: Nationwide Inpatient Sample 1999-2008. Epilepsy Behav 2014;36:53-56. https://doi.org/10.1016/j.yebeh.2014.04.015
  11. Rao SC, Dove G, Cascino GD, Petersen RC. Recurrent seizures in patients with dementia: frequency, seizure types, and treatment outcome. Epilepsy Behav 2009;14:118-120. https://doi.org/10.1016/j.yebeh.2008.08.012
  12. Liu S, Yu W, Lu Y. The causes of new-onset epilepsy and seizures in the elderly. Neuropsychiatr Dis Treat 2016;12:1425-1434.
  13. Amatniek JC, Hauser WA, DelCastillo-Castaneda C, Jacobs DM, Marder K, Bell K, et al. Incidence and predictors of seizures in patients with Alzheimer's disease. Epilepsia 2006;47:867-872. https://doi.org/10.1111/j.1528-1167.2006.00554.x
  14. Cheng CH, Liu CJ, Ou SM, Yeh CM, Chen TJ, Lin YY, et al. Incidence and risk of seizures in Alzheimer's disease: a nationwide population-based cohort study. Epilepsy Res 2015;115:63-66. https://doi.org/10.1016/j.eplepsyres.2015.05.009
  15. Sjogren T, Sjogren H, Lindgren AG. Morbus Alzheimer and morbus pick; a genetic, clinical and patho-anatomical study. Acta Psychiatr Neurol Scand Suppl 1952;82:1-152.
  16. Scarmeas N, Honig LS, Choi H, Cantero J, Brandt J, Blacker D, et al. Seizures in Alzheimer disease: who, when, and how common? Arch Neurol 2009;66:992-997.
  17. Reeves MJ, Bushnell CD, Howard G, Gargano JW, Duncan PW, Lynch G, et al. Sex differences in stroke: epidemiology, clinical presentation, medical care, and outcomes. Lancet Neurol 2008;7:915-926. https://doi.org/10.1016/S1474-4422(08)70193-5
  18. Thompson HJ, McCormick WC, Kagan SH. Traumatic brain injury in older adults: epidemiology, outcomes, and future implications. J Am Geriatr Soc 2006;54:1590-1595. https://doi.org/10.1111/j.1532-5415.2006.00894.x

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