대한치매학회지 (Dementia and Neurocognitive Disorders)

대한치매학회 (Korean Dementia Association)
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Association of Alzheimer's Disease with the Risk of Developing Epilepsy: a 10-Year Nationwide Cohort Study

  • Lyou, Hyun Ji (Department of Neurology, National Health Insurance Service Ilsan Hospital) ;
  • Seo, Kwon-Duk (Department of Neurology, National Health Insurance Service Ilsan Hospital) ;
  • Lee, Ji Eun (Department of Neurology, National Health Insurance Service Ilsan Hospital) ;
  • Pak, Hae Yong (Research Analysis Team, National Health Insurance Service Ilsan Hospial) ;
  • Lee, Jun Hong (Department of Neurology, National Health Insurance Service Ilsan Hospital)
  • 투고 : 2018.12.06
  • 심사 : 2018.12.31
  • 발행 : 2018.12.31
⟨ 이전 논문 다음 논문 ⟩

초록

Background and Purpose: Previous studies have reported conflicting results about the prevalence of seizures in Alzheimer's disease (AD). There are few epidemiological studies on this topic in Asia. Thus, the objective of this study was to examine demographic and clinical characteristics as well as incidence for seizures in AD patients compared to non-AD patients in a prospective, longitudinal, community-based cohort with a long follow-up. Methods: Data were collected from National Health Insurance Service-National Elderly Cohort (NHIS-elderly) Database to define patients with AD from 2004-2006 using Korean Classification Diseases codes G30 and F00. We performed a 1:5 case-control propensity score matching based on age, sex, and household income. We conducted Cox proportional hazards regression analysis to estimate the risk of epilepsy in AD patients. Results: In the cohort study, patients with AD had higher risk for epilepsy than those without AD, with hazard ratio of 2.773 (95% confidence interval [CI], 2.515-3.057). This study also showed that male gender and comorbidities such as hypertension, hyperlipidemia, diabetes, and chronic kidney disease increased the risk of developing epilepsy. Patients with AD had 1.527 (95% CI, 1.375-1.695) times higher mortality rate than those in the control group. Conclusions: AD patients have significantly higher risk of developing epilepsy than non-AD patients.

키워드

참고문헌

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  1. Tau Related Pathways as a Connecting Link between Epilepsy and Alzheimer’s Disease vol.10, pp.10, 2018, https://doi.org/10.1021/acschemneuro.9b00460
  2. Epilepsy in Older People in Sub-Saharan Africa: A Systematic Review vol.17, pp.None, 2018, https://doi.org/10.2147/ndt.s322884
  3. A Severe Dementia Case in End of Life Care with Psychiatric Symptoms Treated by Perampanel vol.11, pp.1, 2018, https://doi.org/10.14581/jer.21012
  4. Comprehensive Management of Daily Living Activities, behavioral and Psychological Symptoms, and Cognitive Function in Patients with Alzheimer's Disease: A Chinese Consensus on the Comprehensive Manage vol.37, pp.7, 2018, https://doi.org/10.1007/s12264-021-00701-z
  5. Astrocyte and glutamate involvement in the pathogenesis of epilepsy in Alzheimer's disease vol.62, pp.7, 2021, https://doi.org/10.1111/epi.16918
  6. Risk of seizures and subclinical epileptiform activity in patients with dementia: A systematic review and meta-analysis vol.72, pp.None, 2021, https://doi.org/10.1016/j.arr.2021.101478