Korean Journal of Otorhinolaryngology-Head and Neck Surgery

Korean Society of Otolaryngology-Head and Neck Surgery (대한이비인후과학회)
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Nasal Trigeminal Chemoreception

비강의 삼차신경 화학수용

  • Kim, Byung Guk (Department of Otorhinolaryngology-Head and Neck Surgery, St. Paul's Hospital, College of Medicine, The Catholic University of Korea) ;
  • Kim, Ji-sun (Department of Otorhinolaryngology-Head and Neck Surgery, St. Paul's Hospital, College of Medicine, The Catholic University of Korea)
  • 김병국 (가톨릭대학교 의과대학 성바오로병원 이비인후과학교실) ;
  • 김지선 (가톨릭대학교 의과대학 성바오로병원 이비인후과학교실)
  • Received : 2018.06.13
  • Accepted : 2018.07.04
  • Published : 2018.11.25
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Abstract

The sensory function of the trigeminal nerve is to provide tactile, proprioceptive, and nociceptive afference by chemical stimulation. Various physical responses of the trigeminal nerve to stimuli help to defend against harmful substances. Recently, many studies have been conducted on solitary chemoreceptor cells innervated by trigeminal nerve. Most volatile organic compounds stimulate both the olfactory and trigeminal nervous systems. In general, the trigeminal nervous system is less sensitive than the olfactory nervous system. Studies have shown that sensation of the trigeminal nerve by chemical stimulation results in inhibition of olfaction. This indicates that the olfactory and trigeminal nerves interact with each other in the central nervous system. It is important to study various noxious stimuli acting on the trigeminal nerve in modern society where environmental concerns are intensifying.

Keywords

References

  1. Parker GH. The relation of smell, taste, and the common chemical sense in vertebrates. J Acad Nat Sci Phila 1912;15:219-34.
  2. Green BG, Mason JR, Kare MR. Chemical senses, vol. 2: irritation. New York: Marcel Dekker, Inc;1990.
  3. Doty RL, Cometto-Muniz JE. Handbook of olfaction and gustation. 2nd ed. New York: Marcel Dekker;2003. p.981-1000.
  4. Kehrli P, Maillot C, Wolff MJ. Anatomy and embryology of the trigeminal nerve and its branches in the parasellar area. Neurol Res 1997;19(1):57-65. https://doi.org/10.1080/01616412.1997.11740773
  5. Viana F. Chemosensory properties of the trigeminal system. ACS Chem Neurosci 2011;2(1):38-50. https://doi.org/10.1021/cn100102c
  6. Rentmeister-Bryant H, Green BG. Perceived irritation during ingestion of capsaicin or piperine: comparison of trigeminal and non-trigeminal areas. Chem Senses 1997;22(3):257-66. https://doi.org/10.1093/chemse/22.3.257
  7. Sekizawa SI, Tsubone H. Nasal receptors responding to noxious chemical irritants. Respir Physiol 1994;96(1):37-48. https://doi.org/10.1016/0034-5687(94)90104-X
  8. Vriens J, Appendino G, Nilius B. Pharmacology of vanilloid transient receptor potential cation channels. Mol Pharmacol 2009;75(6):1262-79. https://doi.org/10.1124/mol.109.055624
  9. Silver WL, Finger TE. The anatomical and electrophysiological basis of peripheral nasal trigeminal chemoreception. Ann N Y Acad Sci 2009;1170:202-5. https://doi.org/10.1111/j.1749-6632.2009.03894.x
  10. Sbarbati A, Osculati F. Solitary chemosensory cells in mammals? Cells Tissues Organs 2003;175(1):51-5. https://doi.org/10.1159/000073437
  11. Finger TE, Bottger B, Hansen A, Anderson KT, Alimohammadi H, Silver WL. Solitary chemoreceptor cells in the nasal cavity serve as sentinels of respiration. Proc Natl Acad Sci U S A 2003;100(15):8981-6. https://doi.org/10.1073/pnas.1531172100
  12. Braun T, Mack B, Kramer MF. Solitary chemosensory cells in the respiratory and vomeronasal epithelium of the human nose: a pilot study. Rhinology 2011;49(5):507-12.
  13. Tizzano M, Cristofoletti M, Sbarbati A, Finger TE. Expression of taste receptors in solitary chemosensory cells of rodent airways. BMC Pulm Med 2011;11:3. https://doi.org/10.1186/1471-2466-11-3
  14. Saunders CJ, Christensen M, Finger TE, Tizzano M. Cholinergic neurotransmission links solitary chemosensory cells to nasal inflammation. Proc Natl Acad Sci U S A 2014;111(16):6075-80. https://doi.org/10.1073/pnas.1402251111
  15. Alimohammadi H, Silver WL. Evidence for nicotinic acetylcholine receptors on nasal trigeminal nerve endings of the rat. Chem Senses 2000;25(1):61-6. https://doi.org/10.1093/chemse/25.1.61
  16. Schreiner BS, Lehmann R, Thiel U, Ziemba PM, Beltran LR, Sherkheli MA, et al. Direct action and modulating effect of (+)- and (-)-nicotine on ion channels expressed in trigeminal sensory neurons. Eur J Pharmacol 2014;728:48-58. https://doi.org/10.1016/j.ejphar.2014.01.060
  17. Thuerauf N, Kaegler M, Dietz R, Barocka A, Kobal G. Dosedependent stereoselective activation of the trigeminal sensory system by nicotine in man. Psychopharmacology (Berl) 1999;142(3):236-43. https://doi.org/10.1007/s002130050885
  18. Tizzano M, Gulbransen BD, Vandenbeuch A, Clapp TR, Herman JP, Sibhatu HM, et al. Nasal chemosensory cells use bitter taste signaling to detect irritants and bacterial signals. Proc Natl Acad Sci U S A 2010;107(7):3210-5. https://doi.org/10.1073/pnas.0911934107
  19. Ogura T, Krosnowski K, Zhang L, Bekkerman M, Lin W. Chemoreception regulates chemical access to mouse vomeronasal organ: role of solitary chemosensory cells. PLoS One 2010;5(7):e11924. https://doi.org/10.1371/journal.pone.0011924
  20. Gulbransen B, Silver W, Finger TE. Solitary chemoreceptor cell survival is independent of intact trigeminal innervation. J Comp Neurol 2008;508(1):62-71. https://doi.org/10.1002/cne.21657
  21. von Skramlik E. Uber die Lokalisation der Empfindungen bei den niederen Sinnen. Zeitschrift fur Sinnesphysiologie 1925;56:69-140.
  22. Doty RL. Intranasal trigeminal detection of chemical vapors by humans. Physiol Behav 1975;14(6):855-9. https://doi.org/10.1016/0031-9384(75)90081-5
  23. Doty RL, Brugger WE, Jurs PC, Orndorff MA, Snyder PJ, Lowry LD. Intranasal trigeminal stimulation from odorous volatiles: psychometric responses from anosmic and normal humans. Physiol Behav 1978;20(2):175-85. https://doi.org/10.1016/0031-9384(78)90070-7
  24. Cometto-Muniz JE, Cain WS. Thresholds for odor and nasal pungency. Physiol Behav 1990;48(5):719-25. https://doi.org/10.1016/0031-9384(90)90217-R
  25. Doty RL, Cometto-Muniz JE, Jalowayski AA, Dalton P, Kendal-Reed M, Hodgson M. Assessment of upper respiratory tract and ocular irritative effects of volatile chemicals in humans. Crit Rev Toxicol 2004;34(2):85-142. https://doi.org/10.1080/10408440490269586
  26. Cometto-Muniz JE, Cain WS, Abraham MH. Chemosensory additivity in trigeminal chemoreception as reflected by detection of mixtures. Exp Brain Res 2004;158(2):196-206.
  27. Cometto-Muniz JE, Cain WS, Abraham MH, Kumarsingh R. Trigeminal and olfactory chemosensory impact of selected terpenes. Pharmacol Biochem Behav 1998;60(3):765-70. https://doi.org/10.1016/S0091-3057(98)00054-9
  28. Cometto-Muniz JE, Cain WS, Abraham MH. Nasal pungency and odor of homologous aldehydes and carboxylic acids. Exp Brain Res 1998;118(2):180-8. https://doi.org/10.1007/s002210050270
  29. Cometto-Muniz JE, Garcia-Medina MR, Calvino AM. Perception of pungent odorants alone and in binary mixtures. Chem Senses 1989;14(1):163-73. https://doi.org/10.1093/chemse/14.1.163
  30. Cometto-Muniz JE, Hernandez SM. Odorous and pungent attributes of mixed and unmixed odorants. Percept Psychophys 1990;47(4):391-9. https://doi.org/10.3758/BF03210879
  31. Cometto-Muniz JE, Cain WS, Abraham MH, Gola JM. Chemosensory detectability of 1-butanol and 2-heptanone singly and in binary mixtures. Physiol Behav 1999;67(2):269-76. https://doi.org/10.1016/S0031-9384(99)00074-8
  32. Cometto-Muniz JE, Cain WS, Abraham MH, Gola JM. Ocular and nasal trigeminal detection of butyl acetate and toluene presented singly and in mixtures. Toxicol Sci 2001;63(2):233-44. https://doi.org/10.1093/toxsci/63.2.233
  33. Katz SH, Talbert EJ. Intensities of odors and irritating effects of warning agents for inflammable and poisonous gases. US Govt Print Off 1930;480:1-37.
  34. Cain WS, Murphy CL. Interaction between chemoreceptive modalities of odour and irritation. Nature 1980;284(5753):255-7. https://doi.org/10.1038/284255a0
  35. Alarie Y. Dose-response analysis in animal studies: prediction of human responses. Environ Health Perspect 1981;42:9-13. https://doi.org/10.1289/ehp.81429
  36. Bos PM, Zwart A, Reuzel PG, Bragt PC. Evaluation of the sensory irritation test for the assessment of occupational health risk. Crit Rev Toxicol 1991;21(6):423-50.
  37. Apter A, Bracker A, Hodgson M, Sidman J, Leung WY. Epidemiology of the sick building syndrome. J Allergy Clin Immunol 1994;94(2 Pt 2):277-88. https://doi.org/10.1053/ai.1994.v94.a56006
  38. Hodgson M, Levin H, Wolkoff P. Volatile organic compounds and indoor air. J Allergy Clin Immunol 1994;94(2 Pt 2):296-303. https://doi.org/10.1053/ai.1994.v94.a56008
  39. Cometto-Muniz JE, Cain WS, Hiraishi T, Abraham MH, Gola JM. Comparison of two stimulus-delivery systems for measurement of nasal pungency thresholds. Chem Senses 2000;25(3):285-91. https://doi.org/10.1093/chemse/25.3.285
  40. Cometto-Muniz JE, Cain WS, Abraham MH. Determinants for nasal trigeminal detection of volatile organic compounds. Chem Senses 2005;30(8):627-42. https://doi.org/10.1093/chemse/bji056