Biomedical Engineering Letters

The Korean Society of Medical and Biological Engineering (대한의용생체공학회)
권호 표지
DOI QR코드

DOI QR Code

Promotion of excisional wound repair by a menstrual blood-derived stem cell-seeded decellularized human amniotic membrane

  • Farzamfar, Saeed (Department of Tissue Engineering and Applied Cell Sciences, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences) ;
  • Salehi, Majid (Department of Tissue Engineering, School of Medicine, Shahroud University of Medical Sciences) ;
  • Ehterami, Arian (Department of Tissue Engineering, School of Medicine, Shahroud University of Medical Sciences) ;
  • Naseri-Nosar, Mahdi (Tissue Engineering and Stem Cells Research Center, Shahroud University of Medical Sciences) ;
  • Vaez, Ahmad (Department of Tissue Engineering and Applied Cell Sciences, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences) ;
  • Zarnani, Amir Hassan (Department of Immunology, School of Public Health, Tehran University of Medical Sciences) ;
  • Sahrapeyma, Hamed (Department of Biomedical Engineering, Science and Research Branch, Islamic Azad University) ;
  • Shokri, Mohammad-Reza (Department of Immunology, School of Medicine, Iran University of Medical Sciences) ;
  • Aleahmad, Mehdi (Department of Immunology, School of Public Health, Tehran University of Medical Sciences)
  • Received : 2018.06.05
  • Accepted : 2018.09.04
  • Published : 2018.11.30
⟨ Previous Next ⟩

Abstract

This is the first study demonstrating the efficacy of menstrual blood-derived stem cell (MenSC) transplantation via decellularized human amniotic membrane (DAM), for the promotion of skin excisional wound repair. The DAM was seeded with MenSCs at the density of $3{\times}10^4cells/cm^2$ and implanted onto a rat's $1.50{\times}1.50cm^2$ full-thickness excisional wound defect. The results of wound closure and histopathological examinations demonstrated that the MenSC-seeded DAM could significantly improve the wound healing compared with DAM-treatment. All in all, our data indicated that the MenSCs can be a potential source for cell-based therapies to regenerate skin injuries.

Keywords

References

  1. Chandika P, Ko S-C, Jung W-K. Marine-derived biological macromolecule-based biomaterials for wound healing and skin tissue regeneration. Int J Biol Macromol. 2015;77:24-35. https://doi.org/10.1016/j.ijbiomac.2015.02.050
  2. Sundaramurthi D, Krishnan UM, Sethuraman S. Electrospun nanofibers as scaffolds for skin tissue engineering. Polym Rev. 2014;54(2):348-76. https://doi.org/10.1080/15583724.2014.881374
  3. Alrubaiy L, Al-Rubaiy KK. Skin substitutes: a brief review of types and clinical applications. Oman Med J. 2009;24(1):4.
  4. Mansbridge J. Skin tissue engineering. J Biomater Sci Polym Ed. 2008;19(8):955-68. https://doi.org/10.1163/156856208784909417
  5. Priya SG, Jungvid H, Kumar A. Skin tissue engineering for tissue repair and regeneration. Tiss Eng Part B Rev. 2008;14(1):105-18. https://doi.org/10.1089/teb.2007.0318
  6. Kim SS, et al. Effects of human amniotic membrane grafts combined with marrow mesenchymal stem cells on healing of full-thickness skin defects in rabbits. Cell Tissue Res. 2009;336(1):59. https://doi.org/10.1007/s00441-009-0766-1
  7. Ilic D, et al. Human amniotic membrane grafts in therapy of chronic non-healing wounds. Br Med Bull. 2016;117(1):59-67. https://doi.org/10.1093/bmb/ldv053
  8. Ishino Y, et al. Amniotic membrane as a carrier for cultivated human corneal endothelial cell transplantation. Invest Ophthalmol Vis Sci. 2004;45(3):800-6. https://doi.org/10.1167/iovs.03-0016
  9. Niknejad H, et al. Properties of the amniotic membrane for potential use in tissue engineering. Eur Cells Mater. 2008;15:88-99.
  10. Dua HS, et al. The amniotic membrane in ophthalmology. Surv Ophthalmol. 2004;49(1):51-77. https://doi.org/10.1016/j.survophthal.2003.10.004
  11. Cooper LJ, et al. An investigation into the composition of amniotic membrane used for ocular surface reconstruction. Cornea. 2005;24(6):722-9. https://doi.org/10.1097/01.ico.0000154237.49112.29
  12. Motamed S, et al. Cell-based skin substitutes accelerate regeneration of extensive burn wounds in rats. Am J Surg. 2017;214(4):762-9. https://doi.org/10.1016/j.amjsurg.2017.04.010
  13. Grueterich M, Espana EM, Tseng SC. Ex vivo expansion of limbal epithelial stem cells: amniotic membrane serving as a stem cell niche. Surv Ophthalmol. 2003;48(6):631-46. https://doi.org/10.1016/j.survophthal.2003.08.003
  14. Duscher D, et al. Stem cells in wound healing: the future of regenerative medicine? A mini-review. Gerontology. 2016;62(2):216-25. https://doi.org/10.1159/000381877
  15. Rodrigues MCO et al. Menstrual blood-derived stem cells: in vitro and in vivo characterization of functional effects. In: Biobanking and cryopreservation of stem cells. Berlin: Springer; 2016. pp. 111-121.
  16. Faramarzi H, et al. The potential of menstrual blood-derived stem cells in differentiation to epidermal lineage: a preliminary report. World J Plast Surg. 2016;5(1):26.
  17. Alcayaga-Miranda F, et al. Characterization of menstrual stem cells: angiogenic effect, migration and hematopoietic stem cell support in comparison with bone marrow mesenchymal stem cells. Stem Cell Res Ther. 2015;6(1):32. https://doi.org/10.1186/s13287-015-0013-5
  18. Chen L, et al. Human menstrual blood-derived stem cells ameliorate liver fibrosis in mice by targeting hepatic stellate cells via paracrine mediators. Stem Cells Transl Med. 2017;6(1):272-84. https://doi.org/10.5966/sctm.2015-0265
  19. Lin J, et al. Plasticity of human menstrual blood stem cells derived from the endometrium. J Zhejiang Univ-Sci B. 2011;12(5):372-80. https://doi.org/10.1631/jzus.B1100015
  20. Vu NB et al. Human menstrual blood-derived stem cell transplantation for acute hind limb ischemia treatment in mouse models. In: Regenerative Medicine. Berlin: Springer; 2015. pp. 205-215.
  21. Verdi J, et al. Endometrial stem cells in regenerative medicine. J Biol Eng. 2014;8(1):20. https://doi.org/10.1186/1754-1611-8-20
  22. Farzamfar S, et al. Sciatic nerve regeneration by transplantation of menstrual blood-derived stem cells. Mol Biol Rep. 2017;44(5):407-12. https://doi.org/10.1007/s11033-017-4124-1
  23. Naseri-Nosar M, et al. Cerium oxide nanoparticle-containing poly (e-caprolactone)/gelatin electrospun film as a potential wound dressing material: in vitro and in vivo evaluation. Mater Sci Eng C. 2017;81:366-72. https://doi.org/10.1016/j.msec.2017.08.013
  24. Wu Y, et al. Mesenchymal stem cells enhance wound healing through differentiation and angiogenesis. Stem Cells. 2007;25(10):2648-59. https://doi.org/10.1634/stemcells.2007-0226
  25. Chen L, et al. Paracrine factors of mesenchymal stem cells recruit macrophages and endothelial lineage cells and enhance wound healing. PLoS One. 2008;3(4):e1886. https://doi.org/10.1371/journal.pone.0001886
  26. Sasaki M, et al. Mesenchymal stem cells are recruited into wounded skin and contribute to wound repair by transdifferentiation into multiple skin cell type. J Immunol. 2008;180(4):2581-7. https://doi.org/10.4049/jimmunol.180.4.2581
  27. Nakagawa H, et al. Human mesenchymal stem cells successfully improve skin-substitute wound healing. Br J Dermatol. 2005;153(1):29-36. https://doi.org/10.1111/j.1365-2133.2005.06554.x
  28. Maxson S, et al. Concise review: role of mesenchymal stem cells in wound repair. Stem cells translational medicine. 2012;1(2):142-9. https://doi.org/10.5966/sctm.2011-0018
  29. Walter M, et al. Mesenchymal stem cell-conditioned medium accelerates skin wound healing: an in vitro study of fibroblast and keratinocyte scratch assays. Exp Cell Res. 2010;316(7):1271-81. https://doi.org/10.1016/j.yexcr.2010.02.026
  30. Xiang B, et al. Transplantation of menstrual blood-derived mesenchymal stem cells promotes the repair of LPS-induced acute lung injury. Int J Mol Sci. 2017;18(4):689. https://doi.org/10.3390/ijms18040689
  31. Badiavas EV, et al. Participation of bone marrow derived cells in cutaneous wound healing. J Cell Physiol. 2003;196(2):245-50. https://doi.org/10.1002/jcp.10260
  32. Kim W-S, et al. Wound healing effect of adipose-derived stem cells: a critical role of secretory factors on human dermal fibroblasts. J Dermatol Sci. 2007;48(1):15-24. https://doi.org/10.1016/j.jdermsci.2007.05.018
  33. Li L, et al. How to improve the survival of transplanted mesenchymal stem cell in ischemic heart? Stem Cells Int. 2016;2016:14.
  34. Hyun JS, et al. Enhancing stem cell survival in vivo for tissue repair. Biotechnol Adv. 2013;31(5):736-43. https://doi.org/10.1016/j.biotechadv.2012.11.003
  35. Ankrum J, Karp JM. Mesenchymal stem cell therapy: two steps forward, one step back. Trends in molecular medicine. 2010;16(5):203-9. https://doi.org/10.1016/j.molmed.2010.02.005
  36. Johnson KE, Wilgus TA. Vascular endothelial growth factor and angiogenesis in the regulation of cutaneous wound repair. Adv Wound Care. 2014;3(10):647-61. https://doi.org/10.1089/wound.2013.0517
  37. Wang X, et al. Feedback activation of basic fibroblast growth factor signaling via the Wnt/b-catenin pathway in skin fibroblasts. Front Pharmacol. 2017;8:32.
  38. Schreier T, Degen E, Baschong W. Fibroblast migration and proliferation during in vitro wound healing. Res Exp Med. 1993;193(1):195-205. https://doi.org/10.1007/BF02576227
  39. Akhavan-Tavakoli M, et al. In vitro differentiation of menstrual blood stem cells into keratinocytes: a potential approach for management of wound healing. Biologicals. 2017;48:66-73. https://doi.org/10.1016/j.biologicals.2017.05.005
  40. Lee DE, Ayoub N, Agrawal DK. Mesenchymal stem cells and cutaneous wound healing: novel methods to increase cell delivery and therapeutic efficacy. Stem Cell Res Therapy. 2016;7(1):37. https://doi.org/10.1186/s13287-016-0303-6
  41. Nikoo S, et al. Effect of menstrual blood-derived stromal stem cells on proliferative capacity of peripheral blood mononuclear cells in allogeneic mixed lymphocyte reaction. J Obstet Gynaecol Res. 2012;38(5):804-9. https://doi.org/10.1111/j.1447-0756.2011.01800.x

Cited by

  1. Porous electrospun poly(ε-caprolactone)/gelatin nanofibrous mat containing cinnamon for wound healing application: in vitro and in vivo study vol.10, pp.1, 2020, https://doi.org/10.1007/s13534-019-00138-4
  2. Kaolin-loaded chitosan/polyvinyl alcohol electrospun scaffold as a wound dressing material: in vitro and in vivo studies vol.29, pp.5, 2020, https://doi.org/10.12968/jowc.2020.29.5.270
  3. Endometrial SUSD2+ Mesenchymal Stem/Stromal Cells in Tissue Engineering: Advances in Novel Cellular Constructs for Pelvic Organ Prolapse vol.11, pp.9, 2018, https://doi.org/10.3390/jpm11090840