Korean Circulation Journal

  • 제48권11호
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  • Pages.1014-1024
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  • 2018
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  • 1738-5520(pISSN)
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  • 1738-5555(eISSN)
대한심장학회 (The Korean Society of Cardiology)
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DOI QR코드

DOI QR Code

Exercise induced Right Ventricular Fibrosis is Associated with Myocardial Damage and Inflammation

  • Rao, Zhijian (School of Kinesiology, Shanghai University of Sport) ;
  • Wang, Shiqiang (Hunan University of Technology) ;
  • Bunner, Wyatt Paul (Department of Kinesiology, East Carolina University) ;
  • Chang, Yun (Sport Health and Rehabilitation Center, China Institute of Sport Science) ;
  • Shi, Rengfei (School of Kinesiology, Shanghai University of Sport)
  • 투고 : 2018.03.09
  • 심사 : 2018.05.30
  • 발행 : 2018.11.30
⟨ 이전 논문 다음 논문 ⟩

초록

Background and Objectives: Intense exercise (IE) induced myocardial fibrosis (MF) showed contradictory findings in human studies, making the relationship between IE and the development of MF unclear. This study aims to demonstrate exercise induced MF is associated with cardiac damage, and inflammation is essential to the development of exercise induced MF. Methods: Sprague-Dawley rats were submitted to daily 60-minutes treadmill exercise sessions at vigorous or moderate intensity, with 8-, 12-, and 16-week durations; time-matched sedentary rats served as controls. Enzyme-linked immunosorbent assay (ELISA) was used to measure serum cardiac troponin I (cTnI) concentration. After completion of the exercise protocol rats were euthanized. Biventricular morphology, ultrastructure, and collagen deposition were then examined. Protein expression of interleukin $(IL)-1{\beta}$ and monocyte chemotactic protein (MCP)-1 was evaluated in both ventricles. Results: After IE, right but not left ventricle (LV) MF occurred. Serum cTnI levels increased and right ventricular damage was observed at the ultrastructure level in rats that were subjected to long-term IE. Leukocyte infiltration into the right ventricle (RV) rather than LV was observed after long-term IE. Long-term IE also increased protein expression of proinflammation factors including $IL-1{\beta}$ and MCP-1 in the RV. Conclusions: Right ventricular damage induced by long-term IE is pathological and the following inflammatory response is essential to the development of exercise induced MF.

키워드

과제정보

연구 과제 주관 기관 : Shanghai University of Sport, National Nature Science Foundation of China, Ministry of Science and Technology of China

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