Psychiatry investigation

  • 제15권12호
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  • Pages.1135-1143
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  • 2018
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  • 1738-3684(pISSN)
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  • 1976-3026(eISSN)
대한신경정신의학회 (Korean Neuropsychiatric Association)
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Differences in Psychopathology between Offspring of Parents with Bipolar I Disorder and Those with Bipolar II Disorder: A Cross-Sectional Study

  • Lee, Hyeon-Ah (Department of Psychiatry, Cheonan Hospital, College of Medicine, Soonchunhyang University) ;
  • Kim, Ji-Sun (Department of Psychiatry, Cheonan Hospital, College of Medicine, Soonchunhyang University) ;
  • Lee, Yeon-Jung (Department of Psychiatry, Seoul Hospital, College of Medicine, Soonchunhyang University) ;
  • Heo, Nam-Hun (Department of Psychiatry, Cheonan Hospital, College of Medicine, Soonchunhyang University) ;
  • Shim, Se-Hoon (Department of Psychiatry, Cheonan Hospital, College of Medicine, Soonchunhyang University) ;
  • Kwon, Young-Joon (Department of Psychiatry, Cheonan Hospital, College of Medicine, Soonchunhyang University)
  • 투고 : 2018.07.29
  • 심사 : 2018.10.22
  • 발행 : 2018.12.31
⟨ 이전 논문 다음 논문 ⟩

초록

Objective The aim of this study was to evaluate differences in psychopathology between offspring of parents with bipolar I disorder (BP-I) and those with bipolar II disorder (BP-II). Methods The sample included 201 offspring between 6 and 17 years of age who had at least one parent with BP-I or BP-II. The offspring were diagnostically evaluated using the Korean Kiddie-Schedule for Affective Disorders and Schizophrenia-Present and Lifetime Version. Psychopathology and Clinical characteristics were evaluated, including lifetime DSM-5 diagnoses, depression, and childhood trauma. Lifetime DSM-5 diagnoses were also compared between schoolchildren aged 6 to 11 years and adolescents aged 12 to 17 years. Results In lifetime DSM-5 diagnoses, offspring of parents with BP-I had significantly increased risk of developing MDD and BP-I than those with BP-II. Regarding clinical characteristics, ADHD rating scale and childhood trauma scale were significantly higher in offspring of parents with BP-I than that in those with BP-II. Conclusion The present study supports that BP-I may be etiologically distinct from BP-II by a possible genetic liability. Our findings indicate that additional research related to bipolar offspring is needed to enhance understanding of differences between BP-I and BP-II.

키워드

과제정보

연구 과제 주관 기관 : Soonchunhyang University

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