Psychiatry investigation

Korean Neuropsychiatric Association (대한신경정신의학회)
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BDNF Methylation and Suicidal Ideation in Patients with Acute Coronary Syndrome

  • Kang, Hee-Ju (Department of Psychiatry, Chonnam National University Medical School) ;
  • Bae, Kyung-Yeol (Department of Psychiatry, Chonnam National University Medical School) ;
  • Kim, Sung-Wan (Department of Psychiatry, Chonnam National University Medical School) ;
  • Shin, Il-Seon (Department of Psychiatry, Chonnam National University Medical School) ;
  • Hong, Young Joon (Department of Cardiology, Chonnam National University Medical School) ;
  • Ahn, Youngkeun (Department of Cardiology, Chonnam National University Medical School) ;
  • Jeong, Myung Ho (Department of Cardiology, Chonnam National University Medical School) ;
  • Yoon, Jin-Sang (Department of Psychiatry, Chonnam National University Medical School) ;
  • Kim, Jae-Min (Department of Psychiatry, Chonnam National University Medical School)
  • Received : 2018.08.16
  • Accepted : 2018.09.20
  • Published : 2018.11.30
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Abstract

Objective Patients with acute coronary syndrome (ACS) are at an increased risk of suicide. It is well known that epigenetic mechanisms may explain the pathophysiology of suicidal behavior including suicidal ideation (SI), but no study has explored these mechanisms in ACS populations. Methods In total, 969 patients were initially recruited within 2 weeks of the acute coronary event and, 711 patients were successfully followed up 1 year after ACS. SI was evaluated using the relevant items on the Montgomery-${\AA}sberg$ Depression Rating Scale and covariates potentially affecting SI were estimated. Results Brain-derived neurotrophic factor (BDNF) hypermethylation was associated with SI in both the acute and chronic phases of ACS, although the association was not statistically significant in the acute phase after applying Bonferroni's correction. Conclusion These results suggested that BDNF hypermethylation may have played a role in an epigenetic predisposition for SI in ACS patients, particularly during the chronic phase.

Keywords

Acknowledgement

Supported by : Chonnam National University Hospital, National Research Foundation of Korea

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