Pediatric Gastroenterology, Hepatology & Nutrition

  • 제21권4호
  • /
  • Pages.347-350
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  • 2018
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  • 2234-8646(pISSN)
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  • 2234-8840(eISSN)
대한소아소화기영양학회 (The Korean Society of Pediatric Gastroenterology, Hepatology and Nutrition)
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Minocycline-Induced Autoimmune Hepatitis: A Rare But Important Cause of Drug-Induced Autoimmune Hepatitis

  • Harmon, Elizabeth G. (Department of Medicine-Pediatrics, Rush University Medical Center) ;
  • McConnie, Randolph (Section of Pediatric Gastroenterology, Rush University Medical Center) ;
  • Kesavan, Anil (Section of Pediatric Gastroenterology, Rush University Medical Center)
  • 투고 : 2017.11.09
  • 심사 : 2017.12.11
  • 발행 : 2018.10.15
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초록

Drug-induced autoimmune hepatitis (DIAIH) is an increasingly recognized form of drug-induced liver injury that leads to a condition similar to idiopathic autoimmune hepatitis. A number of drugs have been associated with DIAIH, minocycline is one of the most well characterized. Minocycline is a semisynthetic tetracycline antibiotic used in the treatment of acne vulgaris. Minocycline-induced autoimmune hepatitis presents with serologic and histologic features similar to idiopathic autoimmune hepatitis. However, the natural history and outcomes of these two conditions differ significantly. The majority of patients with minocycline-induced autoimmune hepatitis experience complete resolution of symptoms after withdrawal of the medication. Some patients may require a short course of steroids and rarely use of an immunomodulator to achieve resolution of disease. Recurrence of symptoms is rare and typically only occurs with reintroduction of minocycline. It is important for primary care providers to consider minocycline-induced autoimmune hepatitis when liver injury develops during minocycline therapy.

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참고문헌

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피인용 문헌

  1. Early ALT response to corticosteroid treatment distinguishes idiosyncratic drug‐induced liver injury from autoimmune hepatitis vol.39, pp.10, 2018, https://doi.org/10.1111/liv.14195
  2. A Cautionary Report of Doxycycline‐Induced Autoimmune Hepatitis vol.71, pp.4, 2018, https://doi.org/10.1002/hep.31029
  3. Drug-induced liver injury: What a dermatologist should know? vol.7, pp.2, 2021, https://doi.org/10.4103/ijdd.ijdd_53_20
  4. Pathogenesis of autoimmune hepatitis vol.13, pp.8, 2018, https://doi.org/10.4254/wjh.v13.i8.879
  5. Toxins mechanism in instigating hepatotoxicity vol.40, pp.4, 2018, https://doi.org/10.1080/15569543.2020.1818105