References
- Brekhman II, Dardymov IV. New substances of plant origin, which increase non-specific resistance. Ann Rev Pharmacol 1968;8:419-30.
- Patela S, Raufb A. Adaptogenic herb ginseng (Panax) as medical food: Status quo and future prospects. Biomed Pharmacother 2017;85:120-7. https://doi.org/10.1016/j.biopha.2016.11.112
- Baeg IH, So SH. The world ginseng market and the ginseng (Korea). J Ginseng Res 2013;37:1-7. https://doi.org/10.5142/jgr.2013.37.1
- Ministry of Food and Drug Safety of the Republic of Korea: Health Functional Food Code (Ministry of Food and Drug Safety Notification, revised 12/21/2016).
- Christensen LP. Ginsenosides: chemistry, biosynthesis, analysis, and potential health effects. Adv Food Nutr Res 2009;55:1-99.
- Shin BK, Kwon SW, Park JH. Chemical diversity of ginseng saponins from Panax ginseng. J Ginseng Res 2015;39:287-298. https://doi.org/10.1016/j.jgr.2014.12.005
- Jiaoa L, Zhanga X, Wanga M, Li B, Liua Z, Liu S. Chemical and antihyperglycemic activity changes of ginseng pectin induced by heat processing. Carbohydrate Polymers 2014;114:567-73. https://doi.org/10.1016/j.carbpol.2014.08.018
- World Health Organization (WHO), Radix Ginseng. WHO Monographs on medicinal plants commonly used in the Newly Independent States (NIS). Genova, Switzerland: World Health Organization; 2010. p. 141-60.
- Blumenthal M. The ABC clinical guide to herbs. Austin, TX: Theime; 2003. p. 211-25.
- Panax ginseng. Monograph. Altern Med Rev. 2009;14:172-6.
- Blumenthal M, Goldberg A, Brinkmann J. Herbal medicine: expanded commission E monographs. Austin, TX: Integrative Medicine Communications; 2000. p. 170-7.
- Wang Y, Choi HK, Brinkmann JA, Jiang X, Huang L. Chemical analysis of Panax quinquefolius (North American ginseng): a review. J Chromatogr A 2015;1426:1-15. https://doi.org/10.1016/j.chroma.2015.11.012
- Zhang YC, Li G, Jiang C, Yang B, Yang HJ, Xu HY, Huang LQ. Tissue-specific distribution of ginsenosides in different aged ginseng and antioxidant activity of ginseng leaf. Molecules 2014;19:1781-99.
- Shan SM, Luo JG, Huang F, Kong LY. Chemical characteristics combined with bioactivity for comprehensive evaluation of Panax ginseng C.A. Meyer in different ages and seasons based on HPLC-DAD and chemometric methods. J Pharm Biomed Anal 2014;89:76-82. https://doi.org/10.1016/j.jpba.2013.10.030
- Lee SM, Bae BS, Park HW, Ahn NG, Cho BG, Cho YL, Kwark YS. Characterization of Korean Red ginseng (Panax ginseng Meyer): history, preparation method, and chemical composition. J Ginseng Res 2015;39:382-91.
- Wang CZ, Anderson S, Du W, He TC, Yuan CS. Red ginseng and cancer treatment. Chinese J Nat Med 216;14:7-16
- Qi LW, Wang CZ, Yuan CS. American ginseng: potential structure-function relationship in cancer chemoprevention. Biochem Pharmacol 2010;80:947-54. https://doi.org/10.1016/j.bcp.2010.06.023
- Kim GN, Lee JS, Song JH, Ch Oh, Kwon YI, Jang HD. Heat processing decreases Amadori products and increases total phenolic content and antioxidant activity of Korean Red ginseng. J Med Food 2010;13:1478-84. https://doi.org/10.1089/jmf.2010.1076
- Matsuura Y, Zheng Y, Takaku T, Kameda K, Okuda H. Isolation and physiological activities of new amino acid derivatives from Korean Red ginseng. Korean J Ginseng Sci 1994;18:204-11.
- Matsuura Y, Hirao Y, Yoshida S, Kunihiro K, Fuwa T, Kasai R, Tanaka O. Study on Red ginseng: new ginsenosides and a note on the occurrence of maltol. Chem Pharm Bull 1984;32:4674-7. https://doi.org/10.1248/cpb.32.4674
- Yuo CR, Yong JJ, Popovich DG. Isolation and characterization of bioactive polyacetylenes Panax ginseng Meyer roots. J Pharmaceut Biomed Anal 2017;139:148-55. https://doi.org/10.1016/j.jpba.2017.02.054
- Kitagawa I, Yoshikawa M, Yoshihara M, Hayashi T, Taniyama T. Chemical studies on crude drug precession. I. On the constituents of ginseng radix rubra (1). Yakugaku Zasshi 1983;103:612. https://doi.org/10.1248/yakushi1947.103.6_612
- Zhang X, Yu L, Bi H, Li X, Ni W, Han H, Li N, Wang B, Zhou Y, Tai G. Total fractionation and characterization of the water soluble polysaccharides isolated from Panax ginseng C.A. Meyer. Carbohydr Polym 2009;77:542-52.
- Kim KH, Jang SA, Kim KS, Park S, Park HJ, Lee SJ, Pyo S, Sohn EH. Effects of non-saponin red ginseng components (NSRG) on functions of macrophages isolated from young and aged mice. J Ginseng Res 2009;33:177-82. https://doi.org/10.5142/JGR.2009.33.3.177
- Im JK, Cho IY, Min KY, Lee HY, Kim SJ, Park YJ, Lew BJ, Kim SW, Joo IW. Comparative study of natural killer cell activity after Red ginseng medication on rat. Korean J Orient Int Med 2008;29:1075-82.
- Kim YS, Park KM, Shin HJ, Song KS, Nam KY, Park JD. Anticancer activities of Red ginseng acidic polysaccharide by activation of macrophages and natural killer cells. Yakhak Hoeji 2002;46:113-9.
- Lee B, Heo H, OH S Lew J. Comparison study of Korean and Chinese ginsengs on the regulation of lymphocyte proliferation and cytokine production. J Ginseng Res 2008;32:250-6. https://doi.org/10.5142/JGR.2008.32.3.250
- Jang SK, Kim JH, Chung YS, Ahn DC, Kang MJ, Lee DG, Kim SH. An experimental study on the effect of immunopotential and the anticancer effect of Red ginseng extract. Korean J Ginseng Sci 1994;18:151-9.
- Lee HY, Lee H. Stimulatory effect of Korean Red ginseng extract on the proliferation and cellular activity of lymphocytes. Korean J Ginseng Sci 1998;22:60-5.
- Yoo DG, Kim MC, Park MK, Song JM, Quan FS, Park KM, Cho YK, Kang SM. Protective Effect of Korean Red ginseng extract on the infections by H1N1 and H3N2 influenza viruses in mice. J Med Food 2012;15:855-62. https://doi.org/10.1089/jmf.2012.0017
- Kim JY, Kim HJ, Kim HJ. Effect of oral administration of Korean Red ginseng on influenza A (H1N1) virus infection. J. Ginseng Res 2011;35:104-10. https://doi.org/10.5142/jgr.2011.35.1.104
- Xu ML, Kim HJ, Choi YR, Kim HJ. Intake of Korean Red ginseng extract and saponin enhances the protection conferred by vaccination with inactivated influenza A virus. J Ginseng Res 2012;36:396-402. https://doi.org/10.5142/jgr.2012.36.4.396
- Park EH, Yum J, Ku KB, Kim HM, Kang YM, Kim JC, Kim JA, Kang YK, Seo SH. Red Ginseng-containing diet helps to protect mice and ferrets from the lethal infection by highly pathogenic H5N1 influenza virus. J Ginseng Res 2014;38:40-6. https://doi.org/10.1016/j.jgr.2013.11.012
- Lee JS, Lee YN, Lee YT, Hwang HS, Kim KH, Ko EJ, Kim MC, Kang SM. Ginseng protects against respiratory syncytial virus by modulating multiple immune cells and inhibiting viral replication. Nutrients 2015;7:1021-36. https://doi.org/10.3390/nu7021021
- Lee JS, Ko EJ, Hwang HS, Lee YN, Kwon YN, Kim MC, Kang SM. Antiviral activity of ginseng extract against respiratory syncytial virus infection. Int J Mol Med 2014;34:183-90. https://doi.org/10.3892/ijmm.2014.1750
- Suh SO, Jeung CH, Cho MY, Soon GS. The effect of Red ginseng for postoperative immune response in gastrointestinal carcinoma. Korean J Ginseng Sci 1988;22:32-42.
- Suh SO, Kim J, Cho MY. Prospective study for Korean Red ginseng extract as an immune modulator following a curative gastric resection in patients with advanced gastric cancer. J Ginseng Res 2004;28:104-10. https://doi.org/10.5142/JGR.2004.28.2.104
- Suh SO, Boo YJ, Park JM, Kim J. Prospective study for Korean Red ginseng extract as an immune modulator following a curative surgery in patients with advanced colon cancer. J Ginseng Res 2007;31:54-9. https://doi.org/10.5142/JGR.2007.31.1.054
- Kaneko H, Nakanishi K. Proof of the mysterious efficacy of ginseng: basic and clinical trials: clinical effects of medical ginseng, Korean Red ginseng: specifically, its anti-stress action for prevention of disease. J Pharmacol Sci 2004;95:158-62. https://doi.org/10.1254/jphs.FMJ04001X5
- Lee CS, Lee JH, Oh M, Choi KM, Jeong MR, Park JD, Kwon DY, Ha KC, Park EO, Lee N, et al. Preventive effect of Korean Red ginseng for acute respiratory illness: a randomized and double-blind clinical trial. J Korean Med Sci 2012;27:1472-8. https://doi.org/10.3346/jkms.2012.27.12.1472
- Cho YK, Sung H, Lee HJ, Joo CH, Cho GJ. Long-term intake of Korean Red ginseng in HIV-1-infected patients: development of resistance mutation to zidovudine is delayed. Int Immunopharmacol 2001;1:1295-2305. https://doi.org/10.1016/S1567-5769(01)00061-3
- Sung H, Kang SM, Lee MS, Kim TG, Cho YK. Korean Red ginseng slows depletion of CD4 T cells in human immunodeficiency virus type 1-infected patients. Clin Dian Lab Immunol 2005;12:497-501.
- Kim HD, Nho HS, Khil JH. The effect of Korean Red ginseng supplement on CK, GOT, peak torque, and ROM after strenuous downhill running. Korean J Sport Sci 2004;15:53-62.
- Yoon SJ, Kim KH, Kim CJ, Park HC, Kang KH, Kim MJ, Kang SM, Kwak UH, Kim HJ. Effects of Red ginseng supplementation on aerobic . anaerobic performance, central and peripheral fatigue. J Ginseng Res 2008;32:210-9. https://doi.org/10.5142/JGR.2008.32.3.210
- Jung HL, Kwak HE, Kim SS, Kim YC, Lee CD, Byurn HK, Kang HY. Effects of Panax ginseng supplementation on muscle damage and inflammation after uphill treadmill running in humans. Am J Chin Med 2011;39:441-50. https://doi.org/10.1142/S0192415X11008944
- Min YK, Chung SH, Lee JS, Kim SS, Shin HD, Lim BV, Shin MC, Jang MH, Kim EH, Kim CJ. Red ginseng inhibits exercise-induced increase in 5-hydroxytryptamine synthesis and tryptophan hydroxylase expression in dorsal raphe of rats. J Pharmacol Sci 2003;93:218-21. https://doi.org/10.1254/jphs.93.218
- Kim SS, Ha SH, Yoo JH. The effects of long term submaximal exercise and Red ginseng administration on the antioxidant enzymes and lipid peroxidation during maximal exercise. J Coaching Development 2006;8:233-42.
- Lee SH, Park CW, Lee IR, Han BH. Effect of ginseng saponin on the biosynthesis of prostaglandins. Korean J Ginseng Sci 1989;13:202-10.
- Yu JY, Jin YR, Lee JJ, Chung JH, Noh JY, You SH, Kim KN, Im JH, Lee JH, Seo JM, et al. Antiplatelet and antithrombotic activities of Korean Red ginseng. Arch Pharm Res 2006;29:898-903. https://doi.org/10.1007/BF02973912
- Park KM, Rhee MH, Park HJ. Panaxadiol and panaxatriol from Panax ginseng C. A. Meyer inhibit the synthesis of thromboxane A2 in adrenaline-stimulated human platelet aggregations. Korean J. Ginseng Sci 1994;18:44-8.
- Yamamoto K, Hirai A, Tamura Y, Yoshida S. In vitro and in vivo effect of ginseng saponins, major components of Korean Red ginseng on human platelet aggregation and arachidonic acid metabolism. J Med Pharmaceu Soc WAKAN-YAKU 1988;5:184-90.
- Shin KS, Lee JJ, Jin YR, Yu JY, Park ES, Im JH, You SH, Oh KW, Lee MK, Wee JJ, et al. Effect of Korean Red ginseng extract on blood circulation in healthy volunteers: a randomized, double-blind, placebo-controlled trial. J Ginseng Res 2007;31:109-16. https://doi.org/10.5142/JGR.2007.31.2.109
- Lee JH, Park HJ. Effects of intaking of Red ginseng products on human platelet aggregation and blood lipids. J Ginseng Sci 1998;22:173-80.
- Hirai A. Studies on the mechanisms of anti-platelet and anti-atherosclerotic effects of Korean Red ginseng: focusing on arachidonic acid cascade. In: Proc'99 Korea-Japan Ginseng Sym. Korea Ginseng Research Institute, Seoul, Korea; 1999. p. 16-31.
- Benishin CG, Lee R, Wang LC, Liu HJ. Effects of ginsenoside Rb1 on central cholinergic metabolism. Pharmacol 1991;42:223-9. https://doi.org/10.1159/000138801
- Benishin CG. Action of ginsenoside Rb1 on choline uptake in central cholinergic nerve endings. Neurochem Int 1992;21:1-5.
- Salim KN, McEwen BS, Cha HM. Ginsenoside Rb1 regulates ChAT, NGF and trkA mRNA expression in the rat brain. Mol Brain Res 1997;47:177-82. https://doi.org/10.1016/S0169-328X(97)00042-9
- Nishijo H, Uwano T, Zhong YM, Ono T. Proof of the mysterious efficacy of ginseng: basic and clinical trials: effects of Red ginseng on learning and memory deficits in an animal model of amnesia. J Pharmacol 2004;95:145-52.
- Zhao H, Li Q, Zhang Z, Pei X, Wang J, Li Y. Long-term ginsenoside consumption prevents memory loss in aged SAMP8 mice by decreasing oxidative stress and up-regulating the plasticity-related proteins in hippocampus. Brain Res 2009;1256:111-22. https://doi.org/10.1016/j.brainres.2008.12.031
- Lee Y, OH S. Administration of Red ginseng ameliorates memory decline in aged mice. J Ginseng Res 2015;39:250-6. https://doi.org/10.1016/j.jgr.2015.01.003
- Wen TC, Yoshimura H, Matsuda S, Lim JH, Sakanaka M. Ginseng root prevents learning disability and neuronal loss in gerbils with 5-minute forebrain ischemia. Acta Neuropathol 1996;91:15-22.
- Kennedy DO, Reay JL, Scholey AB. Effects of 8 weeks administration of Korean Panax ginseng extract on the mood and cognitive performance of healthy individuals. J Ginseng Res 2007;31:34-43. https://doi.org/10.5142/JGR.2007.31.1.034
- Heo JH, Lee ST, Chu KC, Oh NJ, Park HJ, Shim JY, Kim M. An open-label trial of Korean Red ginseng as an adjuvant treatment for cognitive impairment in patients with Alzheimer's disease. Eur J Neurology 2008;15:865-8. https://doi.org/10.1111/j.1468-1331.2008.02157.x
- Lee JK, Kim NY, Han YN, Choi J. Effects of pretreated Korean Red ginseng on carbon tetrachloride and galactosamine-induced hepatotoxicity in rats. J Ginseng Res 2003;27:1-10. https://doi.org/10.5142/JGR.2003.27.1.001
- Lee JK, Han YN, Kim NY, Choi J. The therapeutic effects of Korean Red ginseng on carbon tetrachloride and galactosamine-induced hepatotoxicity in rats. J Ginseng Res 2003;27:1-6. https://doi.org/10.5142/JGR.2003.27.1.001
-
Kim YS, Kim YH, Noh JR, Cho ES, Park JH, Son HY. Protective effect of Korean Red ginseng against aflatoxin
$B_{1}$ -induced hepatotoxicity in rat. J. Ginseng Res 2011;35:243-9. https://doi.org/10.5142/jgr.2011.35.2.243 - Abdel-Aziem SH, Hassan AM, Abdel-Wahhab MA. Dietary supplementation with whey protein and ginseng extract counteracts oxidative stress and DNA damage in rats fed an aflatoxin-contaminated diet. Mutation Res 2011;723:65-71. https://doi.org/10.1016/j.mrgentox.2011.04.007
- Seong GS, Chun SG, Chang CC. Hepatoprotective effects of White and Red ginseng extracts on acetaminophen-induce hepatotoxicity in mice. J Ginseng Res 2005;29:131-7. https://doi.org/10.5142/JGR.2005.29.3.131
- Park MS, Cho EJ, Lee SK, Lee EJ, Lee DS, Lee KH, Jeon BH. Korean Red ginseng protects oxidative injury caused by lead poisoning. J Ginseng Res 2010;34:132-7. https://doi.org/10.5142/jgr.2010.34.2.132
-
Kim DJ, Chang CC. The effects of red ginseng extract on antioxidant enzyme activities and lipid peroxidation of the kidney in
${\gamma}$ -postirradiated mice. Korean J Ginseng Sci 1994;18:25-31. - Lee TK, Johnke RM, Allison RR, O'Brien KF, Dobbs Jr J. Radioprotective potential of ginseng. Mutagenesis 2005;20:237-43. https://doi.org/10.1093/mutage/gei041
- Kang KS, Kim HY, Pyo JS, Yokozawa T. Increase in the free radical scavenging activity of ginseng by heat-processing. Biol Pharm Bull 2006;29:750-4. https://doi.org/10.1248/bpb.29.750
- Kim YK, Guo Q, Packer L. Free radical scavenging activity of Red ginseng aqueous extracts. Toxicol 2002;172:149-56. https://doi.org/10.1016/S0300-483X(01)00585-6
- Lee BM, Lee SK, Kim HS. Inhibition of oxidative DNA damage, 8-OHdG, and carbonyl contents in smokers treated with antioxidants (vitamin E, vitamin C, b-carotene and Red ginseng). Cancer Lett 1998;132:219-27. https://doi.org/10.1016/S0304-3835(98)00227-4
- Kim JY, park JY, Kang HJ, Kim OY, Lee JH. Beneficial effects of Korean Red ginseng on lymphocyte DNA damage, antioxidant enzyme activity, and LDL oxidation in healthy participants: a randomized, double-blind, placebocontrolled trial. Nut J 2012;11:47-58. https://doi.org/10.1186/1475-2891-11-47
- Seo SK, Hong Y, Yun BY, Chon SJ, Jung YS, Park JH, Cho SH, Choi YS, Lee BS. Antioxidative effects of Korean Red ginseng in postmenopausal women: a double-blind randomized controlled trial. J Ethnopharmacol 2014;154:753-7. https://doi.org/10.1016/j.jep.2014.04.051
- Kim SY, Seo SK, Choi YM, Jeon YE, Lim KJ, Cho SH, Choi YS, Lee BS. Effects of Red ginseng supplementation on menopausal symptoms and cardiovascular risk factors in postmenopausal women: a double-blind randomized controlled trial. Menopause 2012;19:461-6. https://doi.org/10.1097/gme.0b013e3182325e4b
- Kim HS, Yoon YJ, Lee JM, Lee CH, Jang JB, Lee KS, Cho JH. A Clinical Study on the effect of Red ginseng for postmenopausal hot flushes. J Oriental Obstetrics Gynecol 2009;22:132-9.
- Ogita S. Clinical effectiveness of Korea ginseng on climacteric disturbances and its possible mechanism of action. Korean J Ginseng Sci 1990;14:162-6.
- Kikuchi Y, Tode T, Hirata J, Nakata H, Kita T. Clinical usefulness of Korean Red ginseng in postmenopausal women with severe climacteric disturbance. J Ginseng Res 2003;27:98-102. https://doi.org/10.5142/JGR.2003.27.3.098
- Tode T, Kikuchi Y. Effect of Korean Red ginseng on psychological functions in patients with severe climacteric syndromes: a comprehensive study from the viewpoint of traditional KAMPO-medicine and western medicine. J Ginseng Res 2003;27:110-4. https://doi.org/10.5142/JGR.2003.27.3.110
- Oh KJ, Chae MJ, Lee HS, Hong HD, Park K. Effects of Korean Red ginseng on sexual arousal in menopausal women: placebo-controlled, double-blind crossover clinical study. J Sex Med 2010;7:1469-77. https://doi.org/10.1111/j.1743-6109.2009.01700.x
- Gui Q, Xu Z, Xu k, Yang Y. The efficacy of ginseng-related therapies in type 2 diabetes mellitus. Medicine 2016;96:e2584.
- Lee HW, Choi J, Lee YJ, Kil KJ, Lee MS. Ginseng for managing menopausal woman's health. A systematic review of double-blind, randomized, placebocontrolled trials. Medicine 2016;95:e4914. https://doi.org/10.1097/MD.0000000000004914
- Jang DJ, Lee MS, Shin BC, Lee YC, Ernst E. Red ginseng for treating erectile dysfunction: a systematic review. Br J Clin pharmacol 2008;66:444-50. https://doi.org/10.1111/j.1365-2125.2008.03236.x
- Jin X, Che D, Zhang Z, Yan H, Jia Z, Jia X. Ginseng consumption and risk of cancer: a meta-analysis. J Ginseng Res 2016;40:268-77.
- Vuksan V, Sung MK, Sievenpiper JL, Stavro PM, Jenkins AL, Di Buono M, Lee KS, Leiter LA, Nam KY, Arnason JT, et al. Korean Red ginseng (Panax ginseng) improves glucose and insulin regulation in wellcontrolled, type 2 diabetes: results of a randomized, double-blind, placebo controlled study of efficacy and safety. Nutr Metab Cardiovasc Dis 2008;18:46-56. https://doi.org/10.1016/j.numecd.2006.04.003
- Bang H, Kwak JH, Ahn HY, Shin DY, Lee JH. Korean Red ginseng improves glucose control in subjects with impaired fasting glucose, impaired glucose tolerance, or newly diagnosed type 2 diabetes mellitus. J Med Food 2014;17:128-34. https://doi.org/10.1089/jmf.2013.2889
- Reay JL, Scholey AB, Milne A, Fenwick J, Kennedy DO. Panax ginseng has no effect on indices of glucose regulation following acute or chronic ingestion in healthy volunteers. Br J Nutr 2009;101:1673-8. https://doi.org/10.1017/S0007114508123418
-
Reeds DN, Patterson BW, Okunade A, Holloszy JO, Polonsky KS, Klein S. Ginseng and ginsenoside Re do not improve
${\beta}$ -cell function or insulin sensitivity in overweight and obese subjects with impaired glucose tolerance or diabetes. Diabetes Care 2011;34:1071-6. https://doi.org/10.2337/dc10-2299 - Sin S, Kim SY, Kim SS. Chronic treatment with ginsenoside Rg3 induces Akt-dependent senescence in human glioma cells. Int J Oncolog 2012;41:1669-74. https://doi.org/10.3892/ijo.2012.1604
- Ota T, Maeda M, Odashima S, Ninomiya-Tsuji J, Tatsuka M. G1 phase-specific suppression of the Cdk2 by ginsenoside Rh2 in cultured murine cells. Life Sci 1996;60:PL39-44.
- Wang CZ, Zhang Z, Wan JY, Zhang CF, Anderson S, He X, Yu C, He TC, Qi LW, Yuan CS. Protopanaxadiol, an active ginseng metabolite, significantly enhances the effects of fluorouracil on colon cancer. Nutrients 2015;7:799-814. https://doi.org/10.3390/nu7020799
- Lee KY, Lee YH, Park JH, Lee SK. Ginsenoside-Rg5 suppresses cyclin E-dependent protein kinase activity via up-regulating p21Cip/WAF1 and downregulating cyclin E in SK-HEP-1 cells. Anticancer Res 1997;17:1067-72.
- Kim SE, Lee YH, Park JH, Lee SK. Ginsenoside-Rs4, a new type of ginseng saponin concurrently induces apoptosis and selectively elevates protein levels of p53 and p21WAF1 in human hepatoma K-HEP-1 cells. Eur J Cancer 1999;35:507-11. https://doi.org/10.1016/S0959-8049(98)00415-8
- Wang HN, Zuo GW, Li CL. Effects of ginsenoside Rb1, Rg1 on proliferation of leukemia K562 cells. J Clin Rehabilit Tissue Engineering Res 2009;13:7829-32.
- Shangguan WJ, Li H, Zhang YH. “Induction of G2/M phase cell cycle arrest and apoptosis by ginsenoside Rf in human osteosarcoma MG-63 cells through the mitochondrial pathway. Oncol Rep 2014;31:305-13. https://doi.org/10.3892/or.2013.2815
- Kim SE, Lee YH, Park JH, Lee SK. Ginsenoside-Rs3, a new diol-type ginseng saponin, selectively elevates protein levels of p53 and p21(WAF1) leading to induction of apoptosis in SK-HEP-1 cells. Anticancer Res 1999;19:487-91.
- Yang Y, Yang WS, Yu T, Sung GH, Park KW, Yoon K, Son YJ, Hwang H, Kwak YS, Lee CM, et al. ATF-2/CREB/IRF-3-targeted anti-inflammatory activity of Korean Red ginseng water extract. J Ethnopharm 2014;154:218-28. https://doi.org/10.1016/j.jep.2014.04.008
- Mochizuki M, Yoo YC, Matsuzawa K, Sato K, Saiki I, Tono-oka S, Samukawa K, Azuma I. Inhibitory effect of tumor metastasis in mice by saponins, ginsenoside-Rb2, 20(R)- and 20(S)-ginsenoside-Rg3, of Red ginseng. Biol Pharm Bull 1995;18:1197-202. https://doi.org/10.1248/bpb.18.1197
- Sur YJ, Na HK, Lee JY, Keum YS. Molecular mechanisms underlying antitumor promoting activities of heat-processed Panax ginseng C.A. Meyer. J Korean Med Sci 2001;16(suppl):S38-41. https://doi.org/10.3346/jkms.2001.16.S.S38
- Shin HJ, Kim YS, Kwak YS, Song YB, Kim YS, Park JD. Enhancement of antitumor effects of paclitaxel (taxol) in combination with Red ginseng acidic polysaccharide (RGAP). Planta Med 2004;70:1033-8. https://doi.org/10.1055/s-2004-832643
- Liu T, Huang Y, Cui D, Huang X, Mao S, Ji L, Song H, Yi C. Inhibitory effect of ginsenoside Rg3 combined with gemcitabine on angiogenesis and growth of lung cancer in mice. BMC Cancer 2009;9:250. https://doi.org/10.1186/1471-2407-9-250
- Zhang Q, Kang X, Zhao W. Antiangiogenic effect of low-dose cyclophosphamide combined with ginsenoside Rg3 on Lewis lung carcinoma. Biochem Biophysic Res Comm 2006;342:824-8. https://doi.org/10.1016/j.bbrc.2006.02.044
- Choi C, Kang G, Min Y. Reversal of P-glycoprotein mediated multidrug resistance by protopanaxatriol ginsenosides from Korean Red ginseng. Planta Med 2003;69:235-40. https://doi.org/10.1055/s-2003-38483
- Kim SM, Lee SY, Yuk DY. Inhibition of NF-??B by ginsenoside Rg3 enhances the susceptibility of colon cancer cells to docetaxel. Arch Pharm Res 2009;32:755-65. https://doi.org/10.1007/s12272-009-1515-4
- Baek SH, Piao XL, Lee UJ, Kim HY, Park JH. Reduction of cisplatin-induced nephrotoxicity by ginsenosides isolated from processed ginseng in cultured renal tubular cells. Biol Pharm Bull 2006;29:2051-5. https://doi.org/10.1248/bpb.29.2051
- Yun TK. Panax ginseng-a non-organ-specific cancer preventive? Lancet Oncol 2001;2:49-55. https://doi.org/10.1016/S1470-2045(00)00196-0
- Yun TK. Experimental and epidemiological evidence on nonorgan specific cancer preventive effect of Korean ginseng and identification of active compounds. Mutat Res 2003;523-524:63-74. https://doi.org/10.1016/S0027-5107(02)00322-6
- Yun TK, Zheng S, Choi S, Cai SR, Lee YS, Liu XY, Cho KJ, Park KY. Non-organspecific preventive effect of long-term administration of Korea Red ginseng extract on incidence of human cancers. J Med Food 2010;13:489-94. https://doi.org/10.1089/jmf.2009.1275
- Chen X, Lee TJ. Ginsenosides-induced nitric oxide mediated relaxation of the rabbit corpus cavernosum. Br J Pharmacol 1995;115:15-8. https://doi.org/10.1111/j.1476-5381.1995.tb16313.x
- Murphy LL, Lee TJ. Ginseng, sex behavior, and nitric oxide. Ann N Y Acad Sci 2002;962:372-7. https://doi.org/10.1111/j.1749-6632.2002.tb04081.x
- Choi YD, Rha KH, Choi HK. In vitro and in vivo experimental effect of Korean Red ginseng on erection. J Urol 1999;162:1508-11. https://doi.org/10.1016/S0022-5347(05)68349-8
- Leung KW, Cheng YK, Mak NK, Chan KKC, Fan TPD, Wong RN. Signaling pathway of ginsenoside-Rg1 leading to nitric oxide production in endothelial cells. FEBS Lett 2006;580:3211-6. https://doi.org/10.1016/j.febslet.2006.04.080
- Wang X, Chu S, Qian T, Chen J, Zhang J. Ginsenoside Rg1 improves male copulatory behavior via nitric oxide/cyclic guanosine monophosphate pathway. J Sex Med 2010;7:743-50. https://doi.org/10.1111/j.1743-6109.2009.01482.x
- Jang DJ, Lee MS, Shin BC, Lee YC, Ernst E. Red ginseng for treating erectile dysfunction; a systematic review. Br J Clin Pharmacol 2008;66:444-50. https://doi.org/10.1111/j.1365-2125.2008.03236.x
- Park HJ, Choe S, Paek NC. Effects of Korean Red ginseng on semen parameters in male infertility patients: a randomized, placebo-controlled, double-blind clinical study. Chin J Integr Med 2016;22:490-5. https://doi.org/10.1007/s11655-015-2139-9
- Lee SA, Kang SG, Lee HJ, Jung KY, Kim L. Effect of Korean Red ginseng on sleep: a randomized, placebo-controlled trial. Sleep Med Psychophysiol 2010;17:85-90.
- Han HJ, Kim HY, Choi JJ, Ahn SY, Lee SH, Oh KW, Kim SY. Effects of Red ginseng extract on sleeping behaviors in human volunteers. J Ethnopharmacol 2013;149:597-9. https://doi.org/10.1016/j.jep.2013.07.005
- Park JW, Lee BJ, Bu Y, Yeo I, Kim J, Ryu B. Effects of Korean Red ginseng on dry mouth: a randomized, placebo-controlled trial. J Ginseng Res 2010;34:183-91. https://doi.org/10.5142/jgr.2010.34.3.183
- Kim JH, Yi SM, Choi JE, Son SW. Study of the efficacy of Korean Red ginseng in the treatment of androgenic alopecia. J Ginseng Res 2009;33:223-8. https://doi.org/10.5142/JGR.2009.33.3.223
- Huang KC. The pharmacology of Chinese herbs. Boca Raton: CRC Press; 1999.
- Pharmacopoeia of the People's Republic of China, volume I. Beijing (CN): Chinese Pharmacopoeia Commission; 2005.
- Kim YS, Woo JY, Han CK, Chang IM. Safety analysis of Panax ginseng in randomized clinical trials: a systematic review. Medicines 2015;2:106-26. https://doi.org/10.3390/medicines2020106
- Ginseng, Panax: MedlinePlus. U. S. National Library of Medicine: http://www.nlm.nih.gov/medlineplus/druginfo/natural/1000.html?print1/4y.
- de Andrade E, de Mesquita AA, Claro Jde A, de Andrade PM, Ortiz V, Paranhos M, Srougi M. Study of the efficacy of Korean Red ginseng in the treatment of erectile dysfunction. Asian J Androl 2007;9:241-4. https://doi.org/10.1111/j.1745-7262.2007.00210.x
- Lim SH, Shin S, Jang JY, Byun SK, Lee YE, Park D, Jeon JH, Lee YK, Lee DM, Lee S, et al. Single- and repeated-dose toxicities of Korean Red ginseng extract in mice. J Vet Med Biotechnol 2005;6:187-202.
- Park SJ, Lim KH, Noh JH, Jeong EJ, Kim YS, Han BC, Lee SH, Moon KS. Subacute oral toxicity study of Korean Red ginseng extract in Sprague-Dawley rats. Toxicol Res 2013;29:285-92. https://doi.org/10.5487/TR.2013.29.4.285
- Hong SK, Lee SJ, Kim YS, Jeon BS, Lim CH. Studies of the safety of Korean ginseng ingested as food substance. In: Pro 4th Int Ginseng Sym. Korea Ginseng and Tobacco Research Institute, Daejeon, Korea; 1984.
- Jo SK, Yook HS, Byun MW. Genoxoticolocy safety of the gamma-irradiated Korean red ginseng in vitro. J Korean Soc Food Nut 1996;25:491-6.
- Shin S, Jang JY, Park D, Yon JM, Baek IJ, Hwang BY, Nam SY, Yun YW, Joo SJ, Kim KY. Korean Red ginseng extract does not cause embryo-fetal death or abnormalities in mice. Birth Defects Res (part B) 2010;89:78-85.
- Lim SH, Shin S, Jang JY, Choi B, Byun SK, Lee YE, Park D, Jeon JH, Nam SY, Yun YW, et al. Reproductive and developmental toxicity study on Korea Red ginseng extract in mice. The Annual report of KNTP. Korea: National Institute of Food and Drug Safety Evaluation; 2005.
- Siegel RK. Ginseng abuse syndrome; problems with the panacea. J Am Med Assoc 1979;241:1641-5.
- Kim DH, Xu YH, Kim YC, Bang KW, Kim JU, Cha SW, He ZM, He H, Jang IB, Zhang LX. Clinical study on food evaluation of Panax ginseng. Korean J Medicinal Crop Sci 2015;23:185-9. https://doi.org/10.7783/KJMCS.2015.23.3.185
- Kim HJ, Chun YJ, Park JD, Kim SI, Roh JK, Jeong TC. Protection of rat liver microsomes against carbon tetrachloride-induced lipid peroxidation by Red ginseng saponin through cytochrome P450 inhibition. Planta Med 1887;63:415-8.
- Liu Y, Zhang JW, Li W, Ma H, Sun J, Deng MC. Yang Ling. Ginsenoside metabolites, rather than naturally occurring ginsenosides, lead to inhibition of human cytochrome P450 enzymes. Toxicol Sci 2006;91:356-64. https://doi.org/10.1093/toxsci/kfj164
- Henderson GL, Harkey MR, Gershwin ME, Hackman RM, Stern JS, Stresser DM. Effects of ginseng components on c-DNA-expressed cytochrome P450 enzyme catalytic activity. Life Sci 1999;65:PL209-14.
- Fang ZZ, Cao YF, Hu CM, Hong M, Sun XY, Ge GB, Liu Y, Zhang YY, Yang L, Sun HZ. Structureeinhibition relationship of ginsenosides towards UDPglucuronosyltransferases (UGTs). Toxicol Appl Pharmacol 2013;267:149-54. https://doi.org/10.1016/j.taap.2012.12.019
- Liu Y, Ma H, Zhang JW, Deng MC, Yang L. Influence of ginsenoside Rh1 and F1 on human cytochrome p450 enzymes. Planta Med 2006;72:126-31. https://doi.org/10.1055/s-2005-873197
- Zhang J, Zhou F,WuX,Gu Y,AiH, Zheng Y, Li Y, ZhangX,Hao G, Sun J, et al. 20(S)-Ginsenoside Rh2 noncompetitively inhibits p-glycoprotein in vitro and in vivo: A case for herb-drug interactions. Drug Metabol Dis 2010;38:2179-87. https://doi.org/10.1124/dmd.110.034793
- Kim DS, Kim Y, Jeon JY, Kim MG. Effect of red ginseng on cytochrome P450 and P-glycoprotein activities in healthy volunteers. J Ginseng Sci 2016;40:375-81. https://doi.org/10.1016/j.jgr.2015.11.005
- Lee YH, Lee BK, Choi YJ, Yoon IK, Chang BC, Gwak HS. Interaction between warfarin and Korean Red ginseng in patients with cardiac valve replacement. Int J Cardiol 2010;145:275-6. https://doi.org/10.1016/j.ijcard.2009.09.553
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