Korean Journal of Clinical Pharmacy (한국임상약학회지)

Korean College Of Clinical Pharmacy (한국임상약학회)
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Bleeding after Taking Dual Antiplatelets and NSAID Concurrently

항혈소판제와 비스테로이드성소염진통제의 동시 투약으로 인한 출혈 사례

  • 서정민 (가천대학교 약학대학) ;
  • 최중혁 (가천대학교 약학대학) ;
  • 손병우 (가천대학교 약학대학) ;
  • 이승민 (가천대학교 약학대학) ;
  • 채현우 (가천대학교 약학대학) ;
  • 강근형 (인천광역시약사회 의약품식품안전센터) ;
  • 지은희 (가천대학교 약학대학)
  • Received : 2018.07.10
  • Accepted : 2018.09.04
  • Published : 2018.09.03
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Abstract

When stenting is applied to treat myocardial infarction, antiplatelet agents are administered to prevent thrombosis, which increases the risk of bleeding. Patients with myocardial infarction are also more likely to have osteoarthritis simultaneously, because both diseases occur frequently in elderly patients. Patients with osteoarthritis often use analgesics, especially nonsteroidal anti-inflammatory drugs (NSAIDs); hence, patients with both diseases use analgesics and antiplatelet agents simultaneously. The risk of bleeding increases with the use of antiplatelet agents and this is further increased when NSAIDs are added. We would like to report a case that reflects this situation. A 60-year-old man underwent stenting after ST-elevation myocardial infarction, and was treated with aspirin and clopidogrel. This patient also received a pelubiprofen prescription from another physician to treat osteoarthritis. After the patient took pelubiprofen twice, he found a bruise on his wrist and reported it to the pharmacist. It is unlikely that this is rare in community pharmacies, so pharmacists should pay careful attention to the concomitant administration of analgesics to patients receiving antiplatelet agents and should provide appropriate education to patients.

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References

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