실내환경 및 냄새 학회지 (Journal of odor and indoor environment)

  • 제17권4호
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  • Pages.315-321
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  • 2018
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  • 2288-9167(pISSN)
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  • 2288-923X(eISSN)
한국실내환경학회 (Korean Society for Indoor Environment)
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생체시료를 이용한 프탈레이트의 실내 노출인자 연구

Study on the indoor exposure factors of phthalates using bio-monitoring data

  • 양지연 (연세대학교 의과대학 환경공해연구소) ;
  • 신동천 (연세대학교 의과대학 예방의학교실) ;
  • 이시은 (연세대학교 의과대학 환경공해연구소) ;
  • 이건우 (연세대학교 의과대학 환경공해연구소) ;
  • 김준혁 (연세대학교 의과대학 환경공해연구소) ;
  • 이용진 (연세대학교 의과대학 환경공해연구소) ;
  • 임영욱 (연세대학교 의과대학 환경공해연구소)
  • Yang, Ji Yeon (Institute for Environmental Research, Yonsei University College of Medicine) ;
  • Shin, Dong Chun (Preventive medicine department, Yonsei university college of medicine) ;
  • Lee, Si Eun (Institute for Environmental Research, Yonsei University College of Medicine) ;
  • Lee, Geon Woo (Institute for Environmental Research, Yonsei University College of Medicine) ;
  • Kim, Joon Hyeog (Institute for Environmental Research, Yonsei University College of Medicine) ;
  • Lee, Yong Jin (Institute for Environmental Research, Yonsei University College of Medicine) ;
  • Lim, Young Wook (Institute for Environmental Research, Yonsei University College of Medicine)
  • 투고 : 2018.05.30
  • 심사 : 2018.12.10
  • 발행 : 2018.12.31
⟨ 이전 논문 다음 논문 ⟩

초록

Phthalate is an endocrine disruptor that interferes with homeostasis and developmental regulation. It is highly toxic to the environment and is associated with various diseases of the human body. Using biological samples from 140 adult subjects, to evaluate the influencing factors which are related to contaminant concentration levels, we used correlation analysis and multiple regression analysis. Lastly, in order to analyze the health effects related to exposure to phthalates, we conducted a risk assessment by estimating acceptable daily intake exposure according to the influential factors. When we compared the concentration level according to influential factors, in general, the subjects who had engaged in home remodeling work had higher urinary phthalate metabolite concentrations levels than the subjects who had not engaged in home remodeling work. We can confirm statistically significant differences in DBP metabolites. In addition, we can confirm the concentration appeared higher in the categories such as using air freshener, sofa and foods. Through conducting a risk assessment of DEHP, BBzP, DiBP, and DnBP by using data on phthalate metabolite concentration in urine, it was found that the average concentration of all metabolites did not exceed TDI.

키워드

과제정보

연구 과제 주관 기관 : 식품의약품안전처

참고문헌

  1. Choi, K. Y,, Cho, K., Seo, S. C., 2017. Environmentally hazardous substances and associated environmental factors in homes of atopic dermatitis children: a case-control study. Journal of Odor and Indoor Environment 16(3), 235-241. (in Korean with English abstract) https://doi.org/10.15250/joie.2017.16.3.235
  2. Choi, S. M., Yoo, S. D., Lee, B. M., 2004. Toxicological characteristics of endocrine-disrupting chemicals: developmental toxicity, carcinogenicity, and mutagenicity. Journal of Toxicology and Environmental Health, Part B Critical Reviews 7(1), 1-24. https://doi.org/10.1080/10937400490253229
  3. Christen, K., 2000. European Union bans phthalate softeners in baby toys. Environmental science and technology 34(1), 11A-11A. https://doi.org/10.1021/es0030616
  4. Chemical Manufacturers Association. 1999. Comments of the Chemical Manufacturers Association phthalate esters panel in response to request for public input on seven phthalate esters. FR Doc. 99-9484. Washington, DC: CMA.
  5. David, R. M., 2000. Exposure to phthalate esters. Environmental health perspectives 108(10), A440.
  6. DeRosa, C., Richter, P., Pohl, H., Jones, D. E., 1998. Environmental exposures that affect the endocrine system: public health implications. Journal of Toxicology and Environmental Health, Part B Critical Reviews 1(1), 3-26. https://doi.org/10.1080/10937409809524541
  7. Dewalque. L., Charlier. C., Pirard. C., 2014. Estimated daily intake and cumulative risk assessment of phthalate diesters in a Belgian general population. Toxicology Letters 231(2), 161-168. https://doi.org/10.1016/j.toxlet.2014.06.028
  8. Gray L. E. Jr., Furr, J., Tatum-Gibbs, K. R., Lambright, C., Sampson, H., Hannas, B. R., Wilson, V. S., Hotchkiss, A., Foster, P. M., 2016. Establishing the "Biological Relevance" of dipentyl phthalate reductions in fetal rat testosterone production and plasma and testis testosterone levels. Toxicological Sciences 149(1), 178-191. https://doi.org/10.1093/toxsci/kfv224
  9. Kay, V. R., Bloom, M. S., Foster, W. G., 2014. Reproductive and developmental effects of phthalate diesters in males. Critical reviews in toxicology 44(6), 467-498. https://doi.org/10.3109/10408444.2013.875983
  10. Kim, H. H., Yang, J. Y., Lee, Y. J., Lee, C. S., Lee, G. W., Park, J. H., Gqak, Y. K., Shin, D. C., Lim, Y. W., 2012. Health risk assessment of phthalate exposure in children's facilities : focused on elementary-schools and institutes. Journal of Odor and Indoor Environment 9(4), 367-381. (in Korean with English abstract)
  11. Koch, H. M., Becker, K., Wittassek, M., Seiwert, M., Angerer, J., Kolossa-Gehring, M., 2007. Di-n-butylphthalate and butylbenzylphthalate-urinary metabolite levels and estimated daily intakes: pilot study for the german environmental survey on children. Journal of Exposure Science and Environmental Epidemiology 17(4), 378-387. https://doi.org/10.1038/sj.jes.7500526
  12. Koo, H. J., Lee, B. M., 2004. Estimated exposure to phthalates in cosmetics and risk assessment. Journal of Toxicology and Environmental Health, Part A 67(23-24), 1901-1914. https://doi.org/10.1080/15287390490513300
  13. Lee, C. W., Jung, T. K., Kim, M. G., 2008. Content of plasticizers and heavy metals in the selling PVC wallpapers. Analytical Science and Technology 21(2), 135-142. (in Korean with English abstract)
  14. Lioy, P. J., Hauser, R., Gennings, C., Koch, H. M., Mirkes, P. E., Schwetz, B. A., Kortenkamp, A., 2015. Assessment of phthalates/phthalate alternatives in children's toys and childcare articles: review of the report including conclusions and recommendation of the chronic hazard advisory panel of the consumer product safety commission. Journal of Exposure Science and Environmental Epidemiology 25(4), 343-353. https://doi.org/10.1038/jes.2015.33
  15. Liu X., Yu J., Li S., Wang H., Liu J., 2012. HPLC method to determine DEHP released into blood from a disposable extracorporeal circulation tube. Journal of Biomedical Engineering 30(4), 756-761.
  16. Meeker, J. D., Calafat, A. M., Hauser, R., 2007. Di (2-ethylhexyl) phthalate metabolites may alter thyroid hormone levels in men. Environmental health perspectives 115(7), 1029-1034. https://doi.org/10.1289/ehp.9852
  17. Ministry of Environment(ME), 2009. The case study to develop a comprehensive exposure assessment guideline.
  18. Praveena, S. M., Teh, S. W., Rajendran, R. K., Kannan, N., Lin, C.-C., Abdullah, R., Kumar, S., 2018. Recent updates on phthalate exposure and human health: a special focus on liver toxicity and stem cell regeneration. Environmental Science and Pollution Research international 25(12), 11333-11342. https://doi.org/10.1007/s11356-018-1652-8
  19. Sun, W. L., Zhu, Y. P., Ni, X. S., Jing, D. D., Yao, Y. T., Ding, W., Liu, Z. H., Ding, G. X., Jiang, J. T., 2018. Potential involvement of Fgf10/Fgfr2 and androgen receptor (AR) in renal fibrosis in adult male rat offspring subjected to prenatal exposure to di-n-butyl phthalate (DBP). Toxicology letters 282, 37-42. https://doi.org/10.1016/j.toxlet.2017.09.009
  20. Trasande, L., Spanier, A. J., Sathyanarayana, S., Attina, T. M., Blustein, J., 2013. Urinary phthalates and increased insulin resistance in adolescents. Pediatrics 132(3), e646-e655. https://doi.org/10.1542/peds.2012-4022
  21. Urbanek-Olejnik, K., Liszewska, M., Winczura, A., Kostka, G., 2016. Changes of c-Myc and DNMT1 mRNA and protein levels in the rat livers induced by dibutyl phthalate treatment. Toxicology and industrial health 32(5), 801-808. https://doi.org/10.1177/0748233713512363
  22. Wang, J., Li, L., Cai, F. Y., Zeng, Q., Yang, X., 2010. Study on the DNA damage of rat lung cells induced by butylbenzyl phthalate, In Proceeding of the 2010 4th International Conference on Bioinformatics and Biomedical Engineering, IEEE, Chengdu, 1-3.
  23. Wormuth, M., Scheringer, M., Vollenweider, M., Hungerbuhler, K., 2006. What are the sources of exposure to eight frequently used phthalic acid esters in europeans?. Risk Analysis 26(3), 803-824. https://doi.org/10.1111/j.1539-6924.2006.00770.x
  24. Yang, J. Y., Kim, H. H., Lee, C. S., Kim, S. D., Shin, D. C., Lim, Y. W., 2009. Evaluation and analysis of exposure levels of phthalate - focused on indoor playgrounds and daycare centers. Journal of Korean Society for Indoor Environment 6(1), 15-26.
  25. Zota, A. R., Calafat, A. M., Woodruff, T. J., 2014. Temporal trends in phthalate exposures: findings from the national health and nutrition examination survey, 2001-2010. Environmental health perspectives 122(3), 235-241. https://doi.org/10.1289/ehp.1306681