Journal of the Korean Physical Society

Korean Physical Society (한국물리학회)
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Synthesis of Synchrotron Radiation-induced Gold Nanoparticles as Radiosensitizer in Radiotherapy

  • Oh, Se An (Department of Radiation Oncology, Yeungnam University Medical Center) ;
  • Park, Jae Won (Department of Radiation Oncology, Yeungnam University Medical Center) ;
  • Kim, Seong Hoon (Department of Radiation Oncology, Yeungnam University Medical Center) ;
  • Kim, Sung Kyu (Department of Radiation Oncology, Yeungnam University Medical Center) ;
  • Yea, Ji Woon (Department of Radiation Oncology, Yeungnam University Medical Center) ;
  • Lee, Su Yong (Pohang Accelerator Laboratory, POSTECH) ;
  • Kang, Hyon Chol (Department of Materials Science and Engineering, Chosun University)
  • Received : 2018.09.03
  • Accepted : 2018.10.10
  • Published : 2018.11.30
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Abstract

This study investigated the feasibility of synthesizing GNPs using synchrotron radiation X-ray for use as a radiosensitizer in radiotherapy, and examined the morphology of the GNPs. Different concentration ratios of 4-mM gold precursor aqueous solution and 4-mM $NaHCO_3$ were mixed. This gold precursor aqueous solution was continuously irradiated with synchrotron radiation in the 4B X-ray microdiffraction beamline of Pohang Light Source (PLS)-II in Korea. The SEM, EDS, TEM, and XRD spectra of the GNPs synthesized using the synchrotron radiation were investigated. The GNPs synthesized using the synchrotron radiation were nanocrystals predominantly in the (111) direction of the face-centered cubic structure. We found that the shape of the gold nanoparticles was icosahedron at the molar concentrations of 0.25 mM:0.25 mM and 0.5 mM:0.5 mM mixed with 4 mM $HAuCl_4{\cdot}3H_2O$ and 4 mM $NaHCO_3$ solutions.

Keywords

Acknowledgement

Supported by : National Research Foundation of Korea (NRF)

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