Journal of Industrial and Engineering Chemistry

  • 제68권
  • /
  • Pages.229-237
  • /
  • 2018
  • /
  • 1226-086X(pISSN)
  • /
  • 1876-794X(eISSN)
한국공업화학회 (The Korean Society of Industrial and Engineering Chemistry)
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DOI QR코드

DOI QR Code

Polysaccharide-based superhydrophilic coatings with antibacterial and anti-inflammatory agent-delivering capabilities for ophthalmic applications

  • Park, Sohyeon (Department of Chemical & Biomolecular Engineering, College of Engineering, Yonsei University) ;
  • Park, Joohee (Department of Ophthalmology, Dongguk University Ilsan Hospital) ;
  • Heo, Jiwoong (Department of Chemical & Biomolecular Engineering, College of Engineering, Yonsei University) ;
  • Lee, Sang-Eun (Department of Internal Medicine, Chung-Ang University College and School of Medicine, Chung-Ang University Hospital) ;
  • Shin, Jong-Wook (Department of Internal Medicine, Chung-Ang University College and School of Medicine, Chung-Ang University Hospital) ;
  • Chang, Minwook (Department of Ophthalmology, Dongguk University Ilsan Hospital) ;
  • Hong, Jinkee (Department of Chemical & Biomolecular Engineering, College of Engineering, Yonsei University)
  • 투고 : 2018.06.29
  • 심사 : 2018.07.28
  • 발행 : 2018.12.25
⟨ 이전 논문 다음 논문 ⟩

초록

Medical silicone tubes are generally used as implants for the treatment of nasolacrimal duct stenosis. However, side effects such as allergic reactions and bacterial infections have been reported following the silicone tube insertion, which cause surgical failure. These drawbacks can be overcome by modifying the silicone tube surface using a functional coating. Here, we report a biocompatible and superhydrophilic surface coating based on a polysaccharide multilayer nanofilm, which can load and release antibacterial and anti-inflammatory agents. The nanofilm is composed of carboxymethylcellulose (CMC) and chitosan (CHI), and fabricated by layer-by-layer (LbL) assembly. The LbL-assembled CMC/CHI multilayer films exhibited superhydrophilic properties, owing to the rough and porous structure obtained by a crosslinking process. The surface coated with the superhydrophilic CMC/CHI multilayer film initially exhibited antibacterial activity by preventing the adhesion of bacteria, followed by further enhanced antibacterial effects upon releasing the loaded antibacterial agent. In addition, inflammatory cytokine assays demonstrated the ability of the coating to deliver anti-inflammatory agents. The versatile nanocoating endows the surface with anti-adhesion and drug-delivery capabilities, with potential applications in the biomedical field. Therefore, we attempted to coat the nanofilm on the surface of an ophthalmic silicone tube to produce a multifunctional tube suitable for patient-specific treatment.

키워드

과제정보

연구 과제 주관 기관 : Korea Health Industry Development Institute (KHIDI), National Research Foundation of Korea (NRF), Yonsei University

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