Journal of Industrial and Engineering Chemistry

  • Volume 68
  • /
  • Pages.220-228
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  • 2018
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  • 1226-086X(pISSN)
  • /
  • 1876-794X(eISSN)
The Korean Society of Industrial and Engineering Chemistry (한국공업화학회)
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Simple surface biofunctionalization of biphasic calcium phosphates for improving osteogenic activity and bone tissue regeneration

  • Shim, Kyu-Sik (Department of Biomedical Science, College of Medicine, Korea University) ;
  • Kim, Hak-Jun (Department of Orthopedic Surgery and Rare Diseases Institute, Korea University Medical College) ;
  • Kim, Sung Eum (Department of Orthopedic Surgery and Rare Diseases Institute, Korea University Medical College) ;
  • Park, Kyeongsoon (Department of Systems Biotechnology, Chung-Ang University)
  • Received : 2018.06.27
  • Accepted : 2018.07.28
  • Published : 2018.12.25
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Abstract

In this study, we found a simple surface biofunctionalization of biphasic calcium phosphate (BCP) based on the high affinity between alendronate and the calcium ions of BCP, and the strong interaction between heparin and bone morphogenic protein-2 (BMP-2). The biofunctionalized BCP did not be precipitated well and display a remarkable enhancement of osteogenic activity of human adipose-derived stem cells by showing increased alkaline phosphatase (ALP), calcium deposition and osteogenic-related genes (i.e., Runx-2, ALP, osteocalcin, and osteopontin), and bone regeneration in the calvarial defect model. Therefore, this simple surface technique can be used to easily functionalize various calcium phosphates.

Keywords

Acknowledgement

Supported by : NRF

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