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모유 수유와 멜라토닌

Breastfeeding and Melatonin

  • 송민유 (농촌진흥청 국립축산과학원) ;
  • 박원서 (농촌진흥청 국립축산과학원) ;
  • 유자연 (농촌진흥청 국립축산과학원) ;
  • 함준상 (농촌진흥청 국립축산과학원)
  • 투고 : 2018.09.19
  • 심사 : 2018.09.21
  • 발행 : 2018.09.30

초록

Breastfeeding is highly recommended due to its benefits for both the infant and mother; however, most mothers predominantly use formula feed. Breastfeeding affords protection against a wide variety of medical conditions that may emerge at different time points over the lifespan, including hospital admissions for respiratory infections and neonatal fever, offspring childhood obesity, and cancer as well as cardiovascular disease, hyperlipidemia, hypertension, and diabetes. Moreover, breastfeeding is expected to decrease the risk of adolescent depression and other psychopathologies. It is also important for the development of the gut, gut-brain axis, and immune system, and night-time breast milk is likely to have higher antioxidant, anti-inflammatory, and immune regulatory effects due to the impact of breast milk melatonin on the infant's developing microbiome and gut permeability. Melatonin can be added to a night-time-specific formula feed; however, it is not included in the Korean Food Additive Codex.

키워드

참고문헌

  1. Aly, H., Elmahdy, H., El-Dib, M., Rowisha, M., Awny, M., El-Gohary, T., Elbatch, M., Hamisa, M. and El-Mashad, A. R. 2015. Melatonin use for neuroprotection in perinatal asphyxia: A randomized controlled pilot study. J. Perinatol. 35:186-191. https://doi.org/10.1038/jp.2014.186
  2. Anderson, G. 2018. Linking the biological underpinnings of depression: Role of mitochondria interactions with melatonin, inflammation, sirtuins, tryptophan catabolites, DNA repair and oxidative and nitrosative stress, with consequences for classification and cognition. Prog. NeuroPsyol. Bio Psychiatry. 80:255-266. https://doi.org/10.1016/j.pnpbp.2017.04.022
  3. Anderson, G. and Maes, M. 2015. The gut-brain axis: The role of melatonin in linking psychiatric, inflammatory and neurodegenerative conditions. Adv. Integr. Med. 2:31-37. https://doi.org/10.1016/j.aimed.2014.12.007
  4. Anderson, G. and Maes, M. 2012. Melatonin: An overlooked factor in schizophrenia and in the inhibition of anti-psychotic side effects. Metab. Brain Dis. 27:113-119. https://doi.org/10.1007/s11011-012-9307-9
  5. Anderson, G., Maes, M. and Berk, M. 2012. Inflammation-related diorders in the tryptophan catabolite pathway in depression and somatization. Adv. Protein Chem. Struct. Biol. 88:27-48.
  6. Anderson, G., Seo, M., Berk, M., Carvalho, A. F. and Maes, M. 2016a. Gut permeability and microbiota in Parkinson's disease: Role of depression, tryptophan catabolites, oxidative and nitrosative stress and melatoninergic pathways. Curr. Pharm. Des. 22:6142-6151. https://doi.org/10.2174/1381612822666160906161513
  7. Anderson, G., Vaillancourt, C., Maes, M. and Reiter, R. J. 2016b. Breastfeeding and melatonin: Implications for improving perinatal health. J. Breastfeeding Biol. 1:8-20.
  8. Anderson, G., Vaillancourt, C., Maes, M. and Reiter, R. J. 2017. Breastfeeding and the gut-brain axis: Is there a role for melatonin? BioMol. Concepts 8:185-195.
  9. Bai, P., Canto, C., Oudart, H., Brunyanszki, A., Cen, Y., Thomas, C., Yamamoto, H., Huber, A., Kiss, B., Houtkooper, R. H., Schoonjans, K., Schreiber, V., Sauve, A. A., Menissier-de, M. J. and Auwerx, J. 2011. PARP-1 inhibition increases mitochondrial metabolism through SIRT1 activation. Cell Metab. 13:461-468. https://doi.org/10.1016/j.cmet.2011.03.004
  10. Bautista-Marquez, A., Velasquez, D. E., Esparza-Agular, M., Luna-Cruz, M., Ruiz-Moran, T., Sugata, K., Jiang, B., Parashar, U., Patel, M. and Richardson, V. 2016. Breastfeeding linked to the reduction of both rotavirus shedding and IgA levels after Roarix immunization in Mexican infants. Vaccine. 34:5284-5289. https://doi.org/10.1016/j.vaccine.2016.09.006
  11. Beijers, R., Riksen-Walraven, J. M. and de Weerth, C. 2013. Cortisol regulation in 12-month-old human infants: Associations with the infants' early history of breastfeeding and co-sleeping. Stress. 16:267-277. https://doi.org/10.3109/10253890.2012.742057
  12. Bekkering, P., Jafri, I., van Overveld, F. J. and Rijkers, G. T. 2013. The intricate association between gut microbiota and development of type 1, type 2 and type 3 diabetes. Expert Rev. Clin. Immunol. 9:1031-41. https://doi.org/10.1586/1744666X.2013.848793
  13. Binns, C., Lee, M. and Low, W. Y. 2016. The long-term public health benefits of breastfeeding. Asia Pac. J. Public Health. 28:7-14. https://doi.org/10.1177/1010539515624964
  14. Bosire, R., Guthrie, B. L., Lohman-Payne, B., Mabuka, J., Majiwa, M., Wariua, G., Mbori-Ngacha, D., Richardson, B., John-Stewart, G. and Farquhar, C. 2007. Longitudinal comparison of chemokines in breastmilk early postpartum among HIV-1-Infected and uninfected Kenyan women. Breastfeed Med. 2:129-138. https://doi.org/10.1089/bfm.2007.0009
  15. Byrne, M., Agerbo, E., Bennedsen, B., Eaton, W. W. and Mortensen, P. B. 2007. Obstetric conditions and risk of first admission with schizophrenia: A Danish national register based study. Schizophr. Res. 97:51-59. https://doi.org/10.1016/j.schres.2007.07.018
  16. Cabinian, A., Sinsimer, D., Tang, M., Zumba, O., Mehta, H., Toma, A., Sant'Angelo, D. and Laouar, Y. 2016. Transfer of maternal immune cells by breastfeeding: Maternal cytotoxic T lymphocytes present in breast milk localize in the Peyer's patches of tenursed infant. PLoS One. 11:e0156762. https://doi.org/10.1371/journal.pone.0156762
  17. Chen, M. H., Li, C. T., Lin, W. C., Wei, H. T., Chang, W. H., Chen, T. J., Pan, T. L., Su, T. P. and Bai, Y. M. 2014. A predisposition for allergies predicts subsequent hepertension, dyslipidemia, and diabetes mellitus among patients with schizophrenia or bipolar disorder: A nationwide longitudinal study. Schizophr. Res. 159:171-175. https://doi.org/10.1016/j.schres.2014.07.029
  18. Chen, H. F. and Su, H. M. 2012. Fish oil supplementation of maternal rats on an n-3 fatty acid-deficient diet prevents depletion of maternal brain regional docosahexaenoic acid levels and has a postpartum anxiolytic effect. J. Nutr. Biochem. 23:299-305. https://doi.org/10.1016/j.jnutbio.2010.12.010
  19. Dagvadorj, A., Ota, E., Shahrook, S., Baljinnyam, O. P., Takehara, K., Hikita, N., Bavuusuren, B., Mori, R. and Nakayama, T. 2016. Hospitalization risk factors for children's lower respiratory tract infection: A population-based, cross-sectional study in Mongolia. Sci. Rep. 6:24615. https://doi.org/10.1038/srep24615
  20. Dai, C., Zheng, C. Q., Meng, F. J., Zhou, Z., Sang, L. X. and Jiang, M. 2013. VSL#3 probiotics exerts the anti-inflammatory activity via Pl3k/Akt and NF-${\kappa}B$ pathway in rat model of DSS-induced colitis. Mol. Cell Biochem. 374:1-11. https://doi.org/10.1007/s11010-012-1488-3
  21. Daulatzai, M. A. 2015. Non-celiac gluten sensitivity triggers gut dysbiosis, neuroinflammation, gut-brain axis dysfunction, and vulnerability for dementia. CNS Neurol. Disord. Drug Targets. 14:110-131. https://doi.org/10.2174/1871527314666150202152436
  22. Erren, T. C. and Reiter, R. J. 2015. Melatonin: A universal time messenger. Neuro. Endocrinol. Lett. 36:187-192.
  23. Floris, I., Billard, H., Boquien, C. Y., Joram-Gauvard, E., Simon, L., Legrand, A., Boscher, C., Roze, J. C., Bolanos-Jimenez, F. and Kaeffer, B. 2015. miRNA analysis by quantitative PCR in preterm human breast. PLoS One. 10:e0140488. https://doi.org/10.1371/journal.pone.0140488
  24. Forsberg, A., West, C. E., Prescott, S. L. and Jenmalm, M. C. 2016. Pre- and probiotics for allergy prevention: Time to revisit recommendations? Clin. Exp. Allergy. 46:1506-1521. https://doi.org/10.1111/cea.12838
  25. Garofalo, R. 2010. Cytokines in human milk. J. Pediatr. 156:S36-40. https://doi.org/10.1016/j.jpeds.2009.11.019
  26. Gibbons, D. L., Haque, S. F., Silberzahn, T., Hamilton, K., Langford, C., Ellis, P., Carr, R. and Haysay, A. C. 2009. Neonates harbour highly active gammadelta T cells with selective impairments in preterm infants. Eur. J. Immunol. 39:1794-1806. https://doi.org/10.1002/eji.200939222
  27. Gitto, E., Karbownik, M., Reiter, R. J., Tan, D. X., Cuzzocrea, S., Chiurazzi, P., Cordaro, S., Corona, G., Trimarchi, G. and Barberi, I. 2001. Effects of melatonin treatment in septic newborns. Pediatr. Res. 50:756-760. https://doi.org/10.1203/00006450-200112000-00021
  28. Groer, M. W., Gregory, K. E., Louis-Jacques, A., Thibeau, S. and Walker, W. A. 2015. The very low birth weight infant microbiome and childhood health. Birth Defects Res. C. Embryo Today. 105:252-264. https://doi.org/10.1002/bdrc.21115
  29. Hamdani, N., Boukouaci, W., Hallouche, M. R., Charron, D., Krishnamoorthy, R., Leboyer, M. and Tamouza, R. 2015. Resolution of a manic episode treated with activated charcoal: Evidence for a brain-gut axis in bipolar disorder. Aust. N. Z. J. Psychiatry. 49:1221-1223. https://doi.org/10.1177/0004867415595873
  30. Hayatbakhsh, M. R., O'Callaghan, M. J., Bor, W., Williams, G. M. and Najman, J. M. 2012. Association of breastfeeding and adolescents' psychopathology: A large prospective study. Breastfeed. Med. 7:480-486. https://doi.org/10.1089/bfm.2011.0136
  31. He, C., Wang, J., Zhang, Z., Yang, M., Li, Y., Tian, X., Ma, T., Tao, J., Zhu, K., Song, Y., Ji, P. and Liu, G. 2016. Mitochondria synthesize melatonin to ameliorate its function and improve mice oocyte's quality under in vitro conditions. Int. J. Mol. Sci. 17. pii:E939. https://doi.org/10.3390/ijms17060939
  32. Hendrick, C. E. and Potter, J. E. 2017. Nativity, country of education, and Mexican-origin women's breastfeeding behaviors in the first 10 months postpartum. Birth. 44:68-77. https://doi.org/10.1111/birt.12261
  33. Huang, C., Liu, W., Cai, J., Weschler, L. B., Wang, X., Hu, Y., Zou, Z., Shen, L. and Sundell, J. 2017. Breastfeeding and timing of first dietary introduction in relation to childhood asthma, allergies, and airway disease: A cross-sectional study. J. Asthma. 54:488-497. https://doi.org/10.1080/02770903.2016.1231203
  34. Huether, G. 1993. The contribution of extrapineal sites of melatonin synthesis to circulating melatonin levels in higher vertebrates. Experientia. 49:665-670. https://doi.org/10.1007/BF01923948
  35. Illnerova, H., Buresova, M. and Presl, J. 1993. Melatonin rhythm in human milk. J. Clin. Endocrinol. Metab. 77:838-841.
  36. Iovene, M. R., Bombace, F., Maresca, R., Sapone, A., Iardino, P., Picardi, A., Marotta, R., Schiraldi, C., Siniscalco, D., Serra, N., de Magistris, L. and Bravaccio, C. 2017. Intestinal dysbiosis and yeast isolation in stool of subjects with autism spectrum disorders. Mycopathologia. 182:349-363. https://doi.org/10.1007/s11046-016-0068-6
  37. Iuvone, R. M., Boatright, J. H., Tosini, G. and Ye, K. 2014. N-acetylserotonin: Circadian activation of the BDNF receptor and neuroprotection in the retina and brain. Adv. Exp. Med. Biol. 801:765-771.
  38. Jansen, J., Beijer, R., Riksen-Walraven, M. and de Weerth, C. 2010. Cortisol reactivity in young infants. Psychoneuroendocrinology. 35:329-338. https://doi.org/10.1016/j.psyneuen.2009.07.008
  39. Jia, L. G., Bamias, G., Arseneau, K. O., Burkly, L. C., Wang, E. C., Gruszka, D., Pizarro, T. T. and Cominelli, F. 2016. A novel role for TL1A/DR3 in protection against intestinal injury and infection. J. Immunol. 197:377-386. https://doi.org/10.4049/jimmunol.1502466
  40. Jiang, H., Ling, Z., Zhang, Y., Mao, H., Ma, Z., Yin, Y., Wang, W., Tan, W., Tan, Z., Shi, J., Li, L. and Ruan, B. 2015. Altered fecal microbiota coposition in patients with major depressive disorder. Brain Behav. Immun. 48:186-194. https://doi.org/10.1016/j.bbi.2015.03.016
  41. Kaneko, I., Sabir, M. S., Dussik, C. M., Whitfield, G. K., Karrys, A., Hsieh, J. C., Haussler, M. R., Meyer, M. B., Pike, J. W. and Jurutka, P. W. 2015. 1,25-Dihydroxy-vitamin D regulates expression of the tryptophan hydroxylase 2 and leptin genes: Implication for behavioral influences of vitamin D. FASEB. 29:4023-4035. https://doi.org/10.1096/fj.14-269811
  42. Katzer, D., Pauli, L., Mueller, A., Reutter, H., Reinsberg, J., Fimmers, R., Bartmann, P. and Bagci, S. 2016. Melatonin concentrations and antioxidative capacity of human breat milk according to gestational age and the time of day. 32:NP105-110. https://doi.org/10.1177/0890334415625217
  43. Lanoix, D., Beghdadi, H., Lafond, J. and Vaillancourt, C. 2008. Human placental trophoblasts synthesize melatonin and express its receptors. J. Pineal Res. 45:50-60. https://doi.org/10.1111/j.1600-079X.2008.00555.x
  44. LeBlanc, J. G., Milani, C., de Giori, G. S., Sesma, F., van Sinderen, D. and Ventura, M. 2013. Bacteria as vitamin suppliers to their host: A gut microbiota perspective. Curr. Opin. Biotechnol. 24:160-168. https://doi.org/10.1016/j.copbio.2012.08.005
  45. Maes, M. and Anderson, G. 2016. Overlapping the tryptophan catabolite (TRYCAT) and melatoninergic pathways in Alzheimer's disease. Curr. Pharm. Des. 22:1074-1085. https://doi.org/10.2174/1381612822666151214125804
  46. Markus, R. P., Silva, C. L., Franco, D. G., Barbosa, E. M. Jr. and Ferreira, Z. S. 2010. Is modulation of nicotinic acetylcholine recepteptors by melatonin relevant for therapy with cholinergic drugs? Pharmacol. Ther. 126:251-262. https://doi.org/10.1016/j.pharmthera.2010.02.009
  47. Matamoros, S., Gras-Leguen, C., Le Vacon, F., Potel, G. and de La Cochetiere, M. F. 2013. Development of intestinal microbiota in infants and its impact on health. Trends Microbiol. 21:167-173. https://doi.org/10.1016/j.tim.2012.12.001
  48. McLoughlin, K., Schluter, J., Rakoff-Nahoum, S., Smith, A. L. and Foster, K. R. 2016. Host selection of microbiota via differential adhesion. Cell Host Microbe. 19:550-559. https://doi.org/10.1016/j.chom.2016.02.021
  49. Meir, M., Flemming, S., Burkard, N., Bergauer, L., Metzger, M., Germer, C. T. and Schlegel, N. 2015. Glial cell line-derived neurotrophic factor promotes barrier maturation and wound healing in intestinal epithelial cells in vitro. Am. J. Physiol. Gastrointest. Liver Physiol. 309:G613-624. https://doi.org/10.1152/ajpgi.00357.2014
  50. Mischke, M. and Plosch, T. 2016. The gut microbiota and their metabolites: Potential implications for the host epigenome. Adv. Exp. Med. Biol. 902:33-44.
  51. Morris, G., Carvalho, A. F., Anderson, G., Galecki, P. and Maes, M. 2016. The many neuroprogressive actions of tryptophan catabolites (TRYCATs) that may be associated with the pathophysiology of neuro-immune diorders. Curr. Pharm. Des. 22:963-977. https://doi.org/10.2174/1381612822666151215102420
  52. Munbit, D., Treneva, M., Peroni, D. G., Colicino, S., Chow, L., Dissanayeke, S., Abrol, P., Sheth, S., Pamoura, A., Boner, A. L., Geddes, D. T., Boyle, R. J. and Warner, J. O. 2016. Colostrum and mature human milk of women from London, Moscow, and Verona: Determinants of immune composition. Nutrients. 8:pii:E695. https://doi.org/10.3390/nu8110695
  53. Nassar, M. F., Younis, N. T., El-Arab, S. E. and Fawzi, F. A. 2011. Neuro-developmental outcome and brain-derived neurotrophic factor level in relation to feeding practice in early infancy. Matern. Child. Nutr. 7:188-197. https://doi.org/10.1111/j.1740-8709.2010.00252.x
  54. Netzer-Tomkins, H., Rubin, L. and Ephros, M. 2016. Breastfeeding is associated with decreased hospitalization for neonatal fever. Breastfeed. Med. 11:218-221. https://doi.org/10.1089/bfm.2016.0007
  55. Newburg, D. S. and Walker, W. A. 2007. Protection of the neonate by the innate immune system of developing gut and of human milk. Pediatr. Res. 61:2-8. https://doi.org/10.1203/01.pdr.0000250274.68571.18
  56. Paulose, J. K. and Cassone, V. M. 2016. The melatonin-sensitive circadian clock of the enteric bacterium Enterobacter aerogenes. Gut Microbes. 7:424-427. https://doi.org/10.1080/19490976.2016.1208892
  57. Pencipe, G., Minnone, G., Strippoli, R., De Pasquale, L., Petrini, S., Caiello, I., Manni, L., De Benedetti, F. and Bracci-Laudiero, L. 2014. Nerve growth factor downregulates inflammatory in human monocytes through TrkA. J. Immunol. 192:3345-3354. https://doi.org/10.4049/jimmunol.1300825
  58. Planer, J. D., Peng, Y., Kau, A. L., Blanton, L. V., Ndao, I. M., Tarr, P. I., Warner, B. B. and Gordon, J. I. 2016. Development of the gut microbiota and mucosal IgA responses in twins and gnotobiotic mice. Nature. 534:263-266. https://doi.org/10.1038/nature17940
  59. Rahman, S. A., Castanon-Cervantes, O., Scheer, F. A., Shea, S. A., Czeisler, C. A., Davidson, A. J. and Lockley, S. W. 2015. Endogenous circadian regulation of proinflammatory cytokines and chemokines in the presence of bacterial lipopolysaccharide in humans. Brain Behav. Immun. 47:4-13. https://doi.org/10.1016/j.bbi.2014.11.003
  60. Richard, C., Lewis, E. D. and Field, C. J. 2016. Evidence for the essentiality of arachidonic and docosahexaenoic acid in the postnatal maternal and infant diet for the development of the infant's immune system early in life. Appl. Physiol. Nutr. Metab. 41:461-475. https://doi.org/10.1139/apnm-2015-0660
  61. Rodriguez, M., Wootla, B. and Anderson, G. 2016. Multiple sclerosis, gut microbiota and permeability: Role of tryptophan catabolites, depression and the driving down of local melatonin. Curr. Pharm. Des. 22:6134-6141. https://doi.org/10.2174/1381612822666160915160520
  62. Schmolka, N., Wencher, M., Hayday, A. C. and Silva-Santos, B. 2015. Epigenetic and transcriptional regulation of ${\gamma}{\delta}$ T cell differentiation: Programming cells for responses in time and space. Semin. Immunol. 27:19-25. https://doi.org/10.1016/j.smim.2015.01.001
  63. Seppo, A. E., Autran, C. A., Bode, L. and Jarvinen, K. M. 2017. Human milk oligosaccharides and development of cow's milk allergy in infants. J. Allergy Clin. Immunol. 139:708-711. e5. https://doi.org/10.1016/j.jaci.2016.08.031
  64. Severance, E. G., Yolken, R. H. and Eaton, W. W. 2016. Autoimmune diseases, gastrointestinal disorders and the microbiome in schizophrenia: More than a gut feeling. Schizophr. Res. 176:23-35. https://doi.org/10.1016/j.schres.2014.06.027
  65. Shao, G., Tian, Y., Wang, H., Liu, F. and Xie, G. 2015. Protective effects of melatonin on lipopolysaccharide-induced mastitis in mice. Int. Immunopharmacol. 29:263-268. https://doi.org/10.1016/j.intimp.2015.11.011
  66. Slyepchenko, A., Maes, M., Machado-Veira, R., Anderson, G., Solmi, M., Sanz, Y., Berk, M. Kohler, C. A. and Carvalho, A. F. 2016. Intestinal dysbiosis, gut hyperpermeability and bacterial translocation: Missing links between depression, obesity and type 2 diatetes? Curr. Pharm. Des. 22:6087-6106. https://doi.org/10.2174/1381612822666160922165706
  67. Smith-Brown, P., Morrison, M., Krause, L. and Davies, P. S. 2016. Mothers secretor status affects development of childrens microbiota composition and function: A pilot study. PLoS One. 11:e0161211. https://doi.org/10.1371/journal.pone.0161211
  68. Smith, L. A., Geller, N. L., Kellams, A. L., Colson, E. R., Rybin, D. V., Heeren, T. and Corwin, M. J. 2016. Infant sleep location and breastfeeding practices in the United States, 2011-2014. Acad. Pediatr. 16:540-549. https://doi.org/10.1016/j.acap.2016.01.021
  69. Soliman, A., Lacasse, A. A., Lanoix, D., Sagrillo-Fagundes, L., Boulard, V. and Vailancourt, C. 2015. Placental melatonin system is present throughout pregnancy and regulates villous trophoblast differentiation. J. Pineal Res. 59:38-46. https://doi.org/10.1111/jpi.12236
  70. Sommansson, A., Nylander, O. and Sjoblom, M. 2013. Melatonin decreases duodenal epithelial paracellular permeability via a nicotinic receper-dependent pathway in rats in vivo. J. Pineal Res. 54:282-291. https://doi.org/10.1111/jpi.12013
  71. Sordillo, J. E., Zhou, Y., McGeachie, M. J., Ziniti, J., Lange, N., Laranjo, N., Savage, J. R., Carey, V., O'Connor, G., Sandel, M., Strunk, R., Bacharier, L., Zeiger, R., Weiss, S. T., Weinstock, G., Gold, D. R. and Litonjua, A. A. 2017. Factors influencing the infant gut microbiome at age 3-6 months: Finding from the ethnically diverse vitamin D antenatal asthma reduction trial (VDAART). J. Allergy Clin. Immunol. 139:482-491. https://doi.org/10.1016/j.jaci.2016.08.045
  72. Speciale, C., Hares, K., Schwarcz, R. and Brookes, N. 1989. High-affinity uptake of L-kynurenine by a $Na^+$-independent transporter of neutral amino acids in astrocytes. J. Neurosci. 9:2066-2072. https://doi.org/10.1523/JNEUROSCI.09-06-02066.1989
  73. Stefanovic, B., Spasojevic, N., Jovanovic, P., Jasnic, N., Djordjevic, J. and Dronjak, S. 2016. Melatonin mediated antidepressant-like effect in the hippocampus of chronic stress-induced depression rats: Regulating vesicular monoamine transporter 2 and monoamine oxidase A levels. Eur. Neuropsychopharmacol. 26:1629-1637. https://doi.org/10.1016/j.euroneuro.2016.07.005
  74. Tan, D. X., Manchester, L. C., Liu, X., Rosales-Corral, S. A., Acuna-Castroviejo, D. and Reiter, R. J. 2013. Mitochondria and chloroplasts as the original sites of melatonin synthesis: A hyphothesis related to melatonin's primary function and evolution in eukaryotes. J. Pineal Res. 54:127-138. https://doi.org/10.1111/jpi.12026
  75. Thibeau, S., D'Aopolito, K., Minnick, A. F., Dietrich, M. S., Kane, B., Cooley, S. and Groer, M. 2016. Relationships of maternal stress with milk immune components in African American mothers of healthy term infants. Breastfeed Med. 11:6-14. https://doi.org/10.1089/bfm.2015.0117
  76. Thomas, L. S., Targan, S. R., Tsuda, M., Yu, Q. T., Salumbides, B. C., Haritunians, T., Mengesha, E., McGovern, D. P. and Michelsen, K. S. 2017. The TNF family member TL1A induces IL1A induces IL-22 secretion in committed human Th 17 cells via IL-9 induction. J. Leukoc. Biol. 101:727-737. https://doi.org/10.1189/jlb.3A0316-129R
  77. Tollenaar, M. S., Beijers, R., Jansen, J., Riksen-Walraven, J. M. and de Weerth, C. 2011. Maternal prenatal stress and cortisol reactivity to stressors in human infants. Stress. 14:53-65. https://doi.org/10.3109/10253890.2010.499485
  78. Tougaard, P., Skov, S., Pedersen, A. E., Krych, L., Nielsen, D. S., Bahl, M. I., Christensen, E. G., Licht, T. R., Poulsen, S. S., Metzdorff, S. B., Hansen, A. K. and Hansen, C. H. 2015. TL1A regulates TCR${\gamma}{\delta}^+$ intraepithelial lymphocytes and gut microbial composition. Eur. J. Immunol. 45:865-875. https://doi.org/10.1002/eji.201444528
  79. Walters, D., Horton, S., Siregar, A. Y., Pitriyan, P., Hajeebhoy, N., Mathisen, R., Phan, L. T. and Rudert, C. 2016. The cost of not breastfeeding in Southeast Asia. Health Policy Plan. 31:1107-1116. https://doi.org/10.1093/heapol/czw044
  80. Wang, M., Monaco, M. H. and Donovan, S. M. 2016. Impact of early gut microbiota on immune and metabolic development and function. Semin. Fetal Neonatal Med. 21:380-387. https://doi.org/10.1016/j.siny.2016.04.004
  81. Weaver, L. T., Arthur, H. M., Bunn, J. E. and Thomas, J. E. 1998. Human milk IgA concentrations during the first year of lactation. Arch. Dis. Child. 78:235-239. https://doi.org/10.1136/adc.78.3.235
  82. Weitkamp, J. H., Rosen, M. J., Zhao, Z., Koyama, T., Geem, D., Denning, T. L., Rock, M. T., Moore, D. J., Halpern, M. D., Matta, P. and Denning, P. W., 2014. Small intestinal intraepithelial TCR${\gamma}{\delta}^+$ T lymphocytes are present in the premature intestine but selectively reduced in surgical necrotizing enterocolitis. PLoS One 9:e99042. https://doi.org/10.1371/journal.pone.0099042
  83. Willemsen, L. E., Koetsier, M. A., Balvers, M., Beermann, C., Stahl, B. and van Tol, E. A. 2008. Polyunsaturated fatty acids support epithelial barrier integrity and reduce IL-4 mediated permeability in vitro. Eur. J. Nutr. 47:183-191. https://doi.org/10.1007/s00394-008-0712-0
  84. Yurchenko, E., Levings, M. K. and Piccirillo, C. A. 2011. $CD4^+Foxp3^+$ regulatory T cells suppress ${\gamma}{\delta}$ T-cell effector functions in a model of T-cell-induced mucosal inflammation. Eur. J. Immunol. 41:3455-3466. https://doi.org/10.1002/eji.201141814
  85. Zalewski, B. M., Patro, B., Veldhorst, M., Kouwenhoven, S., Crespo, E. P., Calvo, L. J., Koletzko, B., van Goudoever, J. B. and Szajewska, H. 2017. Nutrition of infants and young children (one to three years) and its effect on later health: A systematic review of current recommendations (EarlyNutrition project). Crit. Rev. Food Sci. Nutr. 57:489-500. https://doi.org/10.1080/10408398.2014.888701
  86. Zhao, J., Shi, P., Sun, Y., Sun, J., Dong, J. N., Wang, H. G., Zuo, L. G., Gong, J. F., Li, Y., Gu, L. L., Li, N., Li, J. S. and Zhu, W. M. 2015. DHA protects against experimental colitis in IL-10-deficient mice associated with the modulation of intestinal epithelial barrier function. Br. J. Nutr. 114:181-188. https://doi.org/10.1017/S0007114515001294