Vitiligo in a Patient with Systemic Lupus Erythematosus: A Case Report

전신홍반루푸스 환자에서 병발한 백반증 1예

  • Kwon, Hyoung Il (3rd Air Defense Missile Brigade, Republic of Korea Air Force) ;
  • Oh, Eui Hyun (Department of Dermatology, Hanyang University College of Medicine) ;
  • Jung, Yun Do (Department of Medicine, Hanyang University College of Medicine) ;
  • Ko, Joo Yeon (Department of Dermatology, Hanyang University College of Medicine)
  • 권형일 (공군 제3방공유도탄여단) ;
  • 오의현 (한양대학교 의과대학 피부과학교실) ;
  • 정연도 (한양대학교 의과대학 의학과) ;
  • 고주연 (한양대학교 의과대학 피부과학교실)
  • Received : 2017.09.06
  • Accepted : 2017.12.04
  • Published : 2018.12.31

Abstract

Vitiligo is a multifactorial disorder. Neural, biochemical, and autoimmune mechanisms have been hypothetically suggested as etiopathological contributors to this condition. Autoimmunity focuses primarily on genetic factors and the association between vitiligo and other autoimmune disorders including autoimmune thyroid disease, rheumatoid arthritis, psoriasis, type 1 diabetes, pernicious anemia, and Addison's disease. We describe a 35-year-old man with systemic lupus erythematosus who developed concurrent vitiligo and discoid lupus erythematosus suggesting the possible autoimmune association between these 2 different diseases.

Keywords

References

  1. Alikhan A, Felsten LM, Daly M, Petronic-Rosic V. Vitiligo: a comprehensive overview. J Am Acad Dermatol 2011;65:473-491 https://doi.org/10.1016/j.jaad.2010.11.061
  2. Sun X, Xu A, Wei X, Ouyang J, Lu L, Chen M, et al. Genetic epidemiology of vitiligo: a study of 815 probands and their families from south China. Int J Dermatol 2006;45:1176-1181 https://doi.org/10.1111/j.1365-4632.2006.02907.x
  3. Alkhateeb A, Fain PR, Thody A, Bennett DC, Spritz R. Epidemiology of vitiligo and associated autoimmune diseases in caucasian probands and their families. Pigment Cell Res 2003;16:208-214 https://doi.org/10.1034/j.1600-0749.2003.00032.x
  4. Sehgal VN, Srivastava G. Vitiligo: auto-immunity and immune responses. Int J Dermatol 2006;45:583-590 https://doi.org/10.1111/j.1365-4632.2005.02651.x
  5. Kim KT, Ahn SK, Lee SH, Lee WS. A case of vitiligo associated with systemic lupus erythematosus. Korean J Dermatol 1994;32:1077-1081
  6. Jeon SY, Hong JW, Song KH, Kim KH. Vitiligo developed in a patient with discoid lupus erythematosus. Korean J Dermatol 2012;50:830-833
  7. Dwivedi M, Kemp EH, Laddha NC, Mansuri MS, Weetman AP, Begum R. Regulatory T cells in vitiligo: implications for pathogenesis and therapeutics. Autoimmunity Reviews 2015;14:49-56 https://doi.org/10.1016/j.autrev.2014.10.002
  8. Lee H, Lee M, Lee DY, Kang HY, Kim KH, Choi GS, et al. Prevalence of vitiligo and associated comorbidities in Korea. Yonsei Med J 2015;56:719-725 https://doi.org/10.3349/ymj.2015.56.3.719
  9. Silverberg JI, Silverberg NB. Association between vitiligo extent and distribution and quality-of-life impairment. JAMA Dermatol 2013;149(2):159-164 https://doi.org/10.1001/jamadermatol.2013.927
  10. Nath SK, Kelly JA, Namjou B, Lam T, Bruner GR, Scofield RH, et al. Evidence for a susceptibility gene, SLEV1, on chromosome 17p13 in families with vitiligo-related systemic lupus erythematosus. Am J Hum Genet 2001;69:1401-1406 https://doi.org/10.1086/324470
  11. Spritz RA, Gowan K, Bennett DC, Fain PR. Novel vitiligo susceptibility loci on chromosomes 7 (AIS2) and 8 (AIS3), confirmation of SLEV1 on chromosome 17, and their roles in an autoimmune diathesis. Am J Hum Genet 2004;74:188-191 https://doi.org/10.1086/381134