The Korean journal of helicobacter and upper gastrointestinal research (대한상부위장관⦁헬리코박터학회지)

Korean College of Helicobacter and upper Gastrointestinal Reseaarch (대한상부위장관ㆍ헬리코박터학회)
권호 표지
DOI QR코드

DOI QR Code

A Case of Duodenal Ganglioneuroma Manifesting as a Subepithelial Tumor

상피하 종양으로 발견된 십이지장 신경절신경종 1예

  • Joo, Dong Chan (Department of Internal Medicine, Pusan National University School of Medicine) ;
  • Kim, Gwang Ha (Department of Internal Medicine, Pusan National University School of Medicine) ;
  • Chae, Chul Byung (Department of Internal Medicine, Pusan National University School of Medicine) ;
  • Lee, So Jeong (Department of Pathology, Pusan National University School of Medicine) ;
  • Park, Do Youn (Department of Pathology, Pusan National University School of Medicine)
  • 주동찬 (부산대학교 의학전문대학원 내과학교실) ;
  • 김광하 (부산대학교 의학전문대학원 내과학교실) ;
  • 채철병 (부산대학교 의학전문대학원 내과학교실) ;
  • 이소정 (부산대학교 의학전문대학원 병리학교실) ;
  • 박도윤 (부산대학교 의학전문대학원 병리학교실)
  • Received : 2018.10.05
  • Accepted : 2018.11.09
  • Published : 2018.12.31
⟨ Previous Next ⟩

Abstract

Ganglioneuroma of the gastrointestinal tract is a rare tumor that consists of ganglion cells, nerve fibers, and supporting cells of the enteric nervous system. Ganglioneuromas are usually associated with genetic disorders such as the multiple endocrine neoplasia syndrome or neurofibromatosis. Ganglioneuromas of the gastrointestinal tract predominantly involve the colon and rectum, and reports about duodenal ganglioneuromas are few. Herein, we report a case of duodenal ganglioneuroma treated with endoscopic resection. A 56-year-old female patient visited our hospital because of a subepithelial tumor in the second portion of the duodenum. She had no remarkable medical or family history and revealed no history of genetic disorders. Endoscopic ultrasonography and abdominal computed tomography revealed a tumor located mainly in the submucosal layer, without any regional lymph node involvement. Endoscopic resection of the lesion was performed, and the pathological examination confirmed a duodenal ganglioneuroma.

Keywords

References

  1. Dellinger GW, Lynch CA, Mihas AA. Colonic ganglioneuroma presenting as filiform polyposis. J Clin Gastroenterol 1996;22:66-70. https://doi.org/10.1097/00004836-199601000-00019
  2. Okubo Y, Wakayama M, Nemoto T, et al. Literature survey on epidemiology and pathology of gangliocytic paraganglioma. BMC Cancer 2011;11:187. https://doi.org/10.1186/1471-2407-11-187
  3. Song JH, Ye BD, Yoon YS, et al. A case of isolated ileal ganglioneuroma. Intest Res 2011;9:46-50. https://doi.org/10.5217/ir.2011.9.1.46
  4. Okubo Y, Yokose T, Motohashi O, et al. Duodenal rare neuroendocrine tumor: clinicopathological characteristics of patients with gangliocytic paraganglioma. Gastroenterol Res Pract 2016;2016:5257312.
  5. Kleihues P, Louis DN, Scheithauer BW, et al. The WHO classification of tumors of the nervous system. J Neuropathol Exp Neurol 2002;61:215-225. https://doi.org/10.1093/jnen/61.3.215
  6. DeSchryver-Kecskemeti K, Clouse RE, Goldstein MN, Gersell D, O'Neal L. Intestinal ganglioneuromatosis. A manifestation of overproduction of nerve growth factor? N Engl J Med 1983;308:635-639. https://doi.org/10.1056/NEJM198303173081106
  7. Zarabi M, LaBach JP. Ganglioneuroma causing acute appendicitis. Hum Pathol 1982;13:1143-1146. https://doi.org/10.1016/S0046-8177(82)80256-6
  8. Kang GH, Lee BS, Kang DY, Choi H. The polypoid ganglioneuroma associated with hyperplastic polyposis. Korean J Intern Med 2016;31:788-790. https://doi.org/10.3904/kjim.2014.282
  9. Kim TJ, Lim H, Kang HS, et al. Diffuse ganglioneuromatosis of the colon presenting as a large subepithelial tumor in adults: report of two cases. Korean J Gastroenterol 2015;66:111-115. https://doi.org/10.4166/kjg.2015.66.2.111
  10. Marcum MA, Richardson JD, Kuhns JG. Ganglioneuroma of the terminal ileum. An unusual case of occult gastrointestinal bleeding. Am Surg 1990;56:299-301.
  11. Shekitka KM, Sobin LH. Ganglioneuromas of the gastrointestinal tract. Relation to Von Recklinghausen disease and other multiple tumor syndromes. Am J Surg Pathol 1994;18:250-257. https://doi.org/10.1097/00000478-199403000-00004