Journal of Bone Metabolism (대한골대사학회지)

The Korean Society for Bone and Mineral Research (대한골대사학회)
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Osteoporosis and Osteoporotic Fractures in Gastrointestinal Disease

  • Oh, Hyun Jin (Division of Gastroenterology, Department of Internal Medicine, Center for Cancer Prevention and Detection, National Cancer Center) ;
  • Ryu, Kum Hei (Division of Gastroenterology, Department of Internal Medicine, Center for Cancer Prevention and Detection, National Cancer Center) ;
  • Park, Bum Joon (Division of Gastroenterology, Department of Internal Medicine, Center for Cancer Prevention and Detection, National Cancer Center) ;
  • Yoon, Byung-Ho (Department of Orthopaedic Surgery, Seoul Paik Hospital, Inje University College of Medicine)
  • Received : 2018.11.14
  • Accepted : 2018.11.26
  • Published : 2018.11.30
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Abstract

Patients with gastrointestinal disease (GI) are at risk for osteopenia or osteoporosis, which can lead to fractures. Although these patients may be at risk from a young age, gastroenterologists often overlook this fact in practice. There are well-known GI diseases associated with osteopenia and osteoporosis, such as the post-gastrectomy state, inflammatory bowel disease (IBD), and celiac disease. As there is an increase in the prevalence of IBD patients, newly diagnosed celiac disease in adulthood, and gastric cancer survivors following gastrectomy, bone disease in these patients becomes an important issue. Here, we have discussed osteoporosis and fractures in GI disease, especially in the postgastrectomy state, IBD, and celiac disease. Although the pathogenesis of bone loss in each disease has not been fully identified, we have confirmed that the prevalence of osteoporosis and fractures in each of these diseases is high. There are scarce studies comparing the prevalence of osteoporosis or osteoporotic fractures in GI disease patients with studies in postmenopausal women, and specific guidelines for their management in each disease have not been established. Intensive surveillance and management are needed to ensure that these patients attain peak bone mass for age and sex to prevent fractures.

Keywords

References

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