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Primary Merkel cell carcinoma of the earlobe in a young healthy man

  • Ha, Non Hyeon (Department of Plastic and Reconstructive Surgery, Ajou University Hospital) ;
  • Kim, Sue Kyung (Department of Dermatology, Seoul Medical Center) ;
  • Shin, Yoo Seob (Department of Otolaryngology, Ajou University Hospital) ;
  • Kim, Sue Min (Department of Plastic and Reconstructive Surgery, Ajou University Hospital)
  • Received : 2018.05.02
  • Accepted : 2018.07.17
  • Published : 2018.09.20

Abstract

Merkel cell carcinoma (MCC) is an uncommon neuroendocrine cutaneous tumor with poor prognosis. It has the high rate of recurrence, mortality, regional nodal involvement, and distant metastases. It is difficult to diagnose MCC because of its non-specific clinical findings. It usually occurs on sun-exposed areas of the skin, mostly at head and neck. There is a difference in the incidence and prognosis according to site in the head and neck. However, there is no consented site-specific diagnosis, treatment or follow-up protocol for MCC at the head and neck. We herein report a case of MCC arising in the right earlobe of an otherwise healthy young man who has been diagnosed early, thereby successfully treated. With our closed follow-up, there was no tumor recurrence or complication at 33 months after diagnosis.

Keywords

References

  1. Schadendorf D, Lebbe C, Zur Hausen A, Avril MF, Hariharan S, Bharmal M, et al. Merkel cell carcinoma: epidemiology, prognosis, therapy and unmet medical needs. Eur J Cancer 2017;71: 53-69. https://doi.org/10.1016/j.ejca.2016.10.022
  2. Pectasides D, Pectasides M, Economopoulos T. Merkel cell cancer of the skin. Ann Oncol 2006;17:1489-95. https://doi.org/10.1093/annonc/mdl050
  3. Ott MJ, Tanabe KK, Gadd MA, Stark P, Smith BL, Finkelstein DM, et al. Multimodality management of Merkel cell carcinoma. Arch Surg 1999;134:388-92. https://doi.org/10.1001/archsurg.134.4.388
  4. Boyle F, Pendlebury S, Bell D. Further insights into the natural history and management of primary cutaneous neuroendocrine (Merkel cell) carcinoma. Int J Radiat Oncol Biol Phys 1995;31:315-23. https://doi.org/10.1016/0360-3016(93)E0110-R
  5. Smith DF, Messina JL, Perrott R, Berman CG, Reintgen DS, Cruse CW, et al. Clinical approach to neuroendocrine carcinoma of the skin (Merkel cell carcinoma). Cancer Control 2000;7: 72-83.
  6. Schmid C, Beham A, Feichtinger J, Aubock L, Dietze O. Recurrent and subsequently metastasizing Merkel cell carcinoma in a 7-year-old girl. Histopathology 1992;20:437-9. https://doi.org/10.1111/j.1365-2559.1992.tb01017.x
  7. Buell JF, Trofe J, Hanaway MJ, Beebe TM, Gross TG, Alloway RR, et al. Immunosuppression and Merkel cell cancer. Transplant Proc 2002;34:1780-1. https://doi.org/10.1016/S0041-1345(02)03065-8
  8. Heath M, Jaimes N, Lemos B, Mostaghimi A, Wang LC, Penas PF, et al. Clinical characteristics of Merkel cell carcinoma at diagnosis in 195 patients: the AEIOU features. J Am Acad Dermatol 2008;58:375-81. https://doi.org/10.1016/j.jaad.2007.11.020
  9. Roy S, Das I, Nandi A, Roy R. Primary Merkel cell carcinoma of the oral mucosa in a young adult male: report of a rare case. Indian J Pathol Microbiol 2015;58:214-6. https://doi.org/10.4103/0377-4929.155318
  10. Prabhu S, Smitha RS, Punnya VA. Merkel cell carcinoma of the alveolar mucosa in a young adult: a rare case report. Br J Oral Maxillofac Surg 2010;48:48-50. https://doi.org/10.1016/j.bjoms.2008.12.005
  11. Halvorson CR, McClain S, Rady P, Tyring S, Gaspari AA. Merkel cell carcinoma presenting in a young patient as a forme fruste of variant epidermodysplasia verruciformis. J Am Acad Dermatol 2011;65:667-9. https://doi.org/10.1016/j.jaad.2010.06.007
  12. Koksal Y, Toy H, Talim B, Unal E, Akcoren Z, Cengiz M. Merkel cell carcinoma in a child. J Pediatr Hematol Oncol 2009;31:359-61. https://doi.org/10.1097/MPH.0b013e3181984f6b
  13. Marzban S, Geramizadeh B, Farzaneh MR. Merkel cell carcinoma in a 17-year-old boy, report of a highly aggressive fatal case and review of the literature. Rare Tumors 2011;3:e34.
  14. Rinaldo A, Devaney KO, Ferlito A. Merkel cell carcinoma of the auricle. Acta Otolaryngol 2005;125:125-9. https://doi.org/10.1080/00016480410017503-1
  15. Day KE, Carroll WR, Rosenthal EL. Parotid gland metastasis in Merkel cell carcinoma of the head and neck: a series of 14 cases. Ear Nose Throat J 2016;95:398-404.
  16. Schwartz JL, Wong SL, McLean SA, Hayman JA, Lao CD, Kozlow JH, et al. NCCN guidelines implementation in the multidisciplinary Merkel Cell Carcinoma Program at the University of Michigan. J Natl Compr Canc Netw 2014;12:434-41. https://doi.org/10.6004/jnccn.2014.0043
  17. Eich HT, Eich D, Staar S, Mauch C, Stutzer H, Groth W, et al. Role of postoperative radiotherapy in the management of Merkel cell carcinoma. Am J Clin Oncol 2002;25:50-6. https://doi.org/10.1097/00000421-200202000-00011
  18. Llombart B, Kindem S, Chust M. Merkel cell carcinoma: an update of key imaging techniques, prognostic factors, treatment, and follow-up. Actas Dermosifiliogr 2017;108:98-107. https://doi.org/10.1016/j.ad.2016.07.021
  19. Smith VA, MaDan OP, Lentsch EJ. Tumor location is an independent prognostic factor in head and neck Merkel cell carcinoma. Otolaryngol Head Neck Surg 2012;146:403-8. https://doi.org/10.1177/0194599811431789

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