DOI QR코드

DOI QR Code

중의학 데이터베이스 (CAJ)를 이용한 소아 비만의 한약치료에 대한 임상 연구 동향

Review of Clinical Studies for Herbal Medicine Treatment on Childhood Obesity - Focusing on Studies from the China Academic Journal (CAJ) -

  • 김서형 (부산대학교 한의학전문대학원) ;
  • 류향 (부산대학교 한의학전문대학원) ;
  • 김기봉 (부산대학교 한의학전문대학원) ;
  • 천진홍 (부산대학교 한의학전문대학원)
  • Kim, Seo Hyeong (Pusan National University School of Korean Medicine) ;
  • Ryu, Hyang (Pusan National University School of Korean Medicine) ;
  • Kim, Kibong (Pusan National University School of Korean Medicine) ;
  • Cheon, Jin Hong (Pusan National University School of Korean Medicine)
  • 투고 : 2018.07.25
  • 심사 : 2018.08.14
  • 발행 : 2018.08.31

초록

Objectives The purpose of this study was to analyze recent traditional Chinese medicine clinical studies for treatment of childhood obesity. Methods We analyzed 11 clinical studies from January, 2000 to March, 2018 about childhood obesity from the China Academic Journal (CAJ) and China National Knowledge Infrastructure (CNKI). All selected studies were Randomized Controlled Trials and analyzed in order of publication year, demographic information, treatment method, evaluation methods, results, adverse reactions and relapse after treatment discontinuation. Results The main Traditional Chinese Medicine (TCM) treatment was the herbal decoctions, granules and pills. In most studies, the total efficacy of the treatment group was reported to be higher than that of the control group. Adverse reactions were found in small number of studies. Frequently used medical herbs were Crataegi Fructus (山?), Atractylodis Rhizoma (蒼朮), Citri Pericarpium (陳皮), Poria (茯?), and Nelumbinis Folium (荷葉). Also, Water-draining and swelling-dispersing medicinal (利水退腫藥), Qi-regulating medicinal (理氣藥), Resolving dampness with aroma medicinal (芳香化濕藥), Blood-activating and stasis-dispelling medicinal (活血祛瘀藥), Qi-tonifying medicinal (補氣藥), and Digestant medicinal (消食藥) were commonly used. Conclusions This study showed that traditional Chinese medicine, especially herbal medicine treatment can be effective and safe option for treating childhood obesity. These research results can be utilized in other clinical studies as well as in treatment of childhood obesity. Additional well-designed randomized controlled trials and systematic reviews are need to confirm the conclusion.

키워드

참고문헌

  1. de Onis M, Blössner M, Borghi E. Global prevalence and trends of overweight and obesity among preschool children. Am J Clin Nutr. 2010;92(5):1257-64. https://doi.org/10.3945/ajcn.2010.29786
  2. Strauss RS, Pollack HA. Epidemic increase in childhood over-weight, 1986-1998. JAMA. 2001;286(22):2845-8. https://doi.org/10.1001/jama.286.22.2845
  3. Oh K, Jang MJ, Lee NY, Moon JS, Lee CG, Yoo MH, Kim YT. Prevalence and trends in obesity among Korean children and adolescents in 1997 and 2005. Korean J Pediatr. 2008;51(9):950-5. https://doi.org/10.3345/kjp.2008.51.9.950
  4. Wolfenden L, Wiggers J, Tursan E, Bell AC. How useful are systematic reviews of child obesity inter- ventions?. Obes Rev. 2010;11(2):159-65. https://doi.org/10.1111/j.1467-789X.2009.00637.x
  5. Deitel M. Overweight and obesity worldwide now estimated to involve 1.7 billion people. Obes Surg. 2003; 13(3):329-30. https://doi.org/10.1381/096089203765887598
  6. Ezzati M, Lopez AD, Rodgers A, Vander Hoorn S, Murray CJ. Selected major risk factors and global and regional burden of disease. Lancet. 2002;360(9343):1347-60. https://doi.org/10.1016/S0140-6736(02)11403-6
  7. Barlow SE, Expert Committee. Expert committee recommendations regarding the prevention, assessment, and treatment of child and adolescent overweight and obesity: summary report. Pediatrics. 2007;120(Suppl4):S164-92. https://doi.org/10.1542/peds.2007-2329C
  8. Ebbeling CB, Feldman HA, Chomitz VR, Antonelli TA, Gortmaker SL, Osganian SK, Ludwig DS. A randomized trial of sugar-sweetened beverages and adolescent body weight. N Engl J Med. 2012;367(15):1407-16. https://doi.org/10.1056/NEJMoa1203388
  9. Cho YG, Song HR, Kim KA, Kang JH, Kang JH, Song YH, Yun HJ, Kim HS. Effect of a school-based intervention for overweight children "fitness class" performed on elementary schools located in Seoul. J Obes Metab Syndr. 2009;18(4):146-57.
  10. Epstein LH, Coleman KJ, Myers MD. Exercise in treating obesity in children and adolescents. Med Sci Sports Exerc. 1996;28(4):428-35. https://doi.org/10.1097/00005768-199604000-00006
  11. Sothern MS. Exercise as a modality in the treatment of childhood obesity. Pediatr Clin North Am. 2001;48(4): 995-1015. https://doi.org/10.1016/S0031-3955(05)70353-9
  12. Cho JH, Oh DS, Hong SH, Ko H, Lee NH, Park SE, Han CW, Kim SM, Kim YC, Kim KS, Choi CW, Shin SM, Kim KT, Choi HS, Lee JH, Kim JY, Kang JY, Lee DS, Ahn YC, Son CG. A nationwide study of the incidence rate of herb-induced liver injury in Korea. Arch Toxicol. 2017;91(12):4009-15. https://doi.org/10.1007/s00204-017-2007-9
  13. Shin DK, Kim JY, Lee JY. A clinical study on the effects of Gwakhyangjunggi-san gamibang on 9 obese children. J Pediatr Korean Med. 2001;15(1):183-94.
  14. Ju JY, Choi JE, Kim KS. A case study on effect of herbal diet an childhood obese patient. J Korean Med Obes Res. 2003;3(1):69-74.
  15. Jang JH, Lee SY. Three cases report about obese children over the middle level. J Pediatr Korean Med. 2004; 18(2):179-90.
  16. Jeong SH, Lee SY. The evaluation about 10 cases of childhood obesity treatment program in oriental medical center. J Pediatr Korean Med. 2004;18(2):161-77.
  17. Lee DH, Kim DG. The effects of Sobieum on decrease of body mass index (BMI) and obesity index of obese children. J Pediatr Korean Med. 2009;23(1):195-203.
  18. Shin MS, Ahn HR. A literature review: more effective apporoach for childhood obesity - based on international papers published from 1996 to 2007. J Korean Med Obes Res. 2007;7(1):9-22.
  19. Yi XC, Liu P. Clinical study of slimming decoction in the treatment of simple obesity in children. Jiangxi J Tradit Chin Med. 2002;(4):4.
  20. Le Q, Wang DX, Xia XH, Liu D. Clinical observation of Heze oral liquid in the treatment of children with simple obesity. Chin J Integr Med. 2002;22(5):384-5.
  21. Yuan J, Guo H. Clinical study on the treatment of simple obesity in children with combination of Caoju drink and dietary fiber. Tianjin J Tradit Chin Med. 2005;(3):205-6.
  22. Duan YY, Huang JN. Therapeutic effect of lean body mixture on childhood simple obesity. Hubei J Tradit Chin Med. 2007;(10):38.
  23. Xiao H, Zhao WG, Yang FA, Li Q, Yang HM. Clinical study of traditional Chinese medicine slimming oral liquid in the treatment of simple obesity in children. Liaoning J Tradit Chin Med. 2008;(10):1517.
  24. Yang FA, Xiao H, Zhang HY, Zhao XJ. Family care of simple obese children treated with traditional Chinese medicine. J Nurs Sci. 2009;(7):43-4.
  25. Li JP. Research on TCM treatment of simple obesity in children. Lishizhen Med Mater Med Res. 2012;(12): 3206-7.
  26. Shen XQ. Clinical observation of Donghe Xiehuang granule in the treatment of simple obesity in children. Shandong Univ Tradit Chin Med. 2014:1-36.
  27. Qin X. Clinical observation of Jiaxing Cangfu Guiling granule in the treatment of simple obesity (dampness type) in children. Heilongjiang Univ Tradit Chin Med. 2016:1-51.
  28. Song XM. Clinical study on the treatment of simple obesity (spleen and stomach dampness type) in children with spleen turbidity and turbidity. Changchun Univ Tradit Chin Med. 2017:1-38.
  29. Wang MF, Zhu Y. The treatment of 40 cases of simple obesity in children with phlegm-dampness and internal obstruction by the lotus seed group. Zhejiang J Tradit Chin Med. 2017;(4):269.
  30. National Oriental Medicine College Collaborative Textbook Compilation Committee. Herbalogy. Seoul: Young Lim Publishing Co. 2011:10-8, 398, 580-1, 609-10.
  31. Ahn DG. Illustrated book of Korean medical herbs. 7th ed. Seoul: Kyohaksa. 1998:684.
  32. Olstad DL, McCargar L. Prevention of overweight and obesity in children under the age of 6 years. Appl Physiol Nutr Metab. 2009;34(4):551-70. https://doi.org/10.1139/H09-016
  33. Lee DH. Childhood obesity. J Korean Med Assoc. 2004;47(4):321-33. https://doi.org/10.5124/jkma.2004.47.4.321
  34. Pediatric Obesity Committee of Korean Society for the study of obesity. Obesity management in children and adolescents: therapeutic approach and treatment for childhood obesity. Korean Society for the study of obesity. 2006:29-37.
  35. Barlow SE, Dietz WH. Obesity evaluation and treatment: expert committee recommendations. The maternal and child health bureau, health resources and services administration and the department of health and human services. Pediatrics. 1998;102(3):e29. https://doi.org/10.1542/peds.102.3.e29
  36. Lee DH, Koh SH, Min YS, Park YH, Park JK, Park SH, Song MY, Shin WJ, Ahn HS. Guidelines for the diagnosis and treatment of childhood obesity. Korean J Obes. 2002;11:57-84.