Korean Journal of Medicinal Crop Science (한국약용작물학회지)

The Korean Society of Medicinal Crop Science (한국약용작물학회)
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Enhancement of Solubility and Nanonization of Phenolic Compound in Extrudate from Angelica gigas Nakai by Hot Melt Extrusion using Surfactant

유화제 첨가 용융압출을 이용한 참당귀 성형체의 페놀성분 나노화 및 용해도 향상

  • Azad, Md Obyedul Kalam (Department of Bio-Health Technology, Kangwon National University) ;
  • Cho, Hyun Jong (Department of Pharmacy, Kangwon National University) ;
  • Go, Eun Ji (Department of Herbal Medicine Resource, Kangwon National University) ;
  • Lim, Jung Dae (Department of Herbal Medicine Resource, Kangwon National University) ;
  • Park, Cheol Ho (Department of Bio-Health Technology, Kangwon National University) ;
  • Kang, Wie Soo (Department of Bio-Health Technology, Kangwon National University)
  • ;
  • 조현종 (강원대학교 약학과) ;
  • 고은지 (강원대학교 생약자원개발학과) ;
  • 임정대 (강원대학교 생약자원개발학과) ;
  • 박철호 (강원대학교 생명건강공학과) ;
  • 강위수 (강원대학교 생명건강공학과)
  • Received : 2018.05.24
  • Accepted : 2018.08.08
  • Published : 2018.08.30
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Abstract

Background: The root of Angelica gigas Nakai is used as a traditional herbal medicine in Korea for the treatment of many diseases. However, the poor water solubility of the active components in A. gigas Nakai is a major obstacle to its bioavailability. Methods and Results: This work aimed at enhancing the solubility of the active compounds of A. gigas Nakai by a chemical (using a surfactant) and physical (hot melt extrusion, HME) crosslinking method. Fourier transform infrared spectroscopy revealed multiple peaks in the case of the extrudate solids, attributable to new functional groups including carboxylic acid, alkynes, and benzene derivatives. Differential scanning calorimetry analysis showed that the extrudate soilid had a lower glass transition temperature ($T_g$) and enthalpy (${\Delta}H$) ($T_g:43^{\circ}C$, ${\Delta}H$ : < 6 J/g) as compared to the non-extrudate ($T_g:68.5^{\circ}C$, ${\Delta}H:123.2$) formulations. X-ray powder diffraction analysis revealed the amorphization of crystalline materials in the extrudate solid. In addition, enhanced solubility (53%), nanonization (403 nm), and a higher amount of extracted phenolic compounds were achieved in the extrudate solid than in the non-extrudate (solubility : 36%, nanonization : 1,499 nm) formulation. Among the different extrudates, acetic acid and span 80 mediated formulations showed superior extractions efficiency. Conclusions: HME successfully enhanced the production of amorphous nano dispersions of phenolic compound including decursin from extrudate solid formulations.

Keywords

References

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