Journal of Korean Medical Science

  • 제33권50호
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  • Pages.318.1-318.10
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  • 2018
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  • 1011-8934(pISSN)
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  • 1598-6357(eISSN)
대한의학회 (Korean Acad Medical Sciences)
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DOI QR코드

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Association of Fatty Acid Ethyl Esters in Meconium of Neonates with Growth Deficits at Birth: a Prospective, Single-Centre Cohort Study

  • Lee, Hyun-Seung (Department of Pediatrics, College of Medicine, The Catholic University of Korea) ;
  • Kim, Yeon Hee (Department of Obstetrics and Gynecology, College of Medicine, The Catholic University of Korea) ;
  • Kwak, Ho-Seok (Department of Bioanalytical Mass Spectrometry, Sunin Bio Corporation) ;
  • Han, Jung-Yeol (Department of Obstetrics and Gynecology, Cheil General Hospital and Women's Healthcare Centre, Dankook University College of Medicine) ;
  • Jo, Sun-Jin (Department of Preventive Medicine, College of Medicine, The Catholic University of Korea) ;
  • Lee, Hae Kook (Department of Psychiatry, Uijeongbu St. Mary's Hospital, College of Medicine, The Catholic University of Korea)
  • 투고 : 2018.03.24
  • 심사 : 2018.08.30
  • 발행 : 2018.12.10
⟨ 이전 논문 다음 논문 ⟩

초록

Background: In this prospective cohort study, we investigated the association between fatty acid ethyl esters (FAEEs) in meconium as biomarkers of prenatal ethanol exposure and growth deficits, as birth outcomes, that constitute several of the key cardinal features of fetal alcohol syndrome. Methods: A total of 157 meconium samples were collected from enrolled infants within 24 hours of birth, and nine FAEEs were quantified using liquid chromatography/tandem mass spectrometry. The relationships between cumulative concentrations of nine species of FAEEs in meconium and birth parameters of growth (age-sex-specific centiles of head circumference [HC], weight, and length) and respective and combined birth outcomes of growth deficits (HC ${\leq}10th$ centile, weight ${\leq}10th$ centile, and length ${\leq}10th$ centile) were determined. Results: Multivariate logistic regression analysis demonstrated that higher cumulative concentrations of meconium FAEEs correlated with elevated risks for HC and length, both, 10th percentile or less (adjusted odds ratio [aOR], 2.94; 95% confidence interval [CI], 1.12-7.74; P = 0.029) and HC and weight and length, all of them, 10th percentile or less (aOR, 3.27; 95% CI, 1.12-9.59; P = 0.031). Conclusion: The elevated cumulative FAEEs in meconium were associated with combined growth deficits at birth, specifically HC and length, both, 10th percentile or less, which might be correlated with detrimental alcohol effects on fetal brain and bone development, suggesting a plausible alcohol-specific pattern of intrauterine growth restriction.

키워드

과제정보

연구 과제 주관 기관 : Korea Centers for Disease Control and Prevention

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피인용 문헌

  1. Korean Mothersafe Center 10th Anniversary: Outcome and Future Prospects vol.23, pp.4, 2018, https://doi.org/10.21896/jksmch.2019.23.4.209