Acknowledgement
Supported by : Ministry of Health and Welfare
References
- Global Strategy for the Diagnosis, Management and Prevention of COPD, Global Initiative for Chronic Obstructive Lung Disease (GOLD) 2018. Available at: http://www.goldcopd.org/.
- Wedzicha, J. A. et al. Indacaterol-glycopyrronium versus salmeterol-fluticasone for COPD. N. Engl. J. Med 374, 2222-2234 (2016). https://doi.org/10.1056/NEJMoa1516385
-
Janson, C. et al. Pneumonia and pneumonia related mortality in patients with COPD treated with fixed combinations of inhaled corticosteroid and long acting
${\beta}$ 2 agonist: observational matched cohort study (PATHOS). BMJ 346, f3306 (2013). https://doi.org/10.1136/bmj.f3306 - Morse,D. & Rosas, I. O. Tobacco smoke-induced lung fibrosis and emphysema. Annu Rev. Physiol. 76, 493-513 (2014). https://doi.org/10.1146/annurev-physiol-021113-170411
- Talikka, M. et al. Genomic impact of cigarette smoke, with application to three smoking-related diseases. Crit. Rev. Toxicol. 42, 877-889 (2012). https://doi.org/10.3109/10408444.2012.725244
- MacNee, W. Oxidants/antioxidants and COPD. Chest 117(5Suppl 1), 303S-317SS (2000).
- Celedon, J. C. et al. The transforming growth factor-beta1 (TGFB1) gene is associated with chronic obstructive pulmonary disease (COPD). Hum. Mol. Genet 13, 1649-1656 (2004). https://doi.org/10.1093/hmg/ddh171
-
Chen, P. Y. et al. Fibroblast growth factor (FGF) signaling regulates transforming growth factor beta (TGF
${\beta}$ )-dependent smooth muscle cell phenotype modulation. Sci. Rep. 6, 33407 (2016). https://doi.org/10.1038/srep33407 -
Lee, B. J. et al. Protective effects of basic fibroblast growth factor in the development of emphysema induced by interferon-
${\gamma}$ . Exp. Mol. Med. 43, 169-178 (2011). https://doi.org/10.3858/emm.2011.43.4.018 - Bikfalvi, A., Klein, S., Pintucci, G. & Rifkin, D. B. Biological roles of fibroblast growth factor-2. Endocr. Rev. 18, 26-45 (1997).
- Nugent, M. A. & Iozzo, R. V. Fibroblast growth factor-2. Int. J. Biochem. Cell Biol. 32, 115-120 (2000). https://doi.org/10.1016/S1357-2725(99)00123-5
- Burgess, J. K. The role of the extracellular matrix and specific growth factors in the regulation of inflammation and remodelling in asthma. Pharmacol. Ther. 122, 19-29 (2009). https://doi.org/10.1016/j.pharmthera.2008.12.002
- Hoshino, M., Takahashi, M. & Aoike, N. Expression of vascular endothelial growth factor, basic fibroblast growth factor, and angiogenin immunoreactivity in asthmatic airways and its relationship to angiogenesis. J. Allergy Clin. Immunol. 107, 295-301 (2001). https://doi.org/10.1067/mai.2001.111928
- Redington, A. E. et al. Basic fibroblast growth factor in asthma: measurement in bronchoalveolar lavage fluid basally and following allergen challenge. J. Allergy Clin. Immunol. 107, 384-387 (2001). https://doi.org/10.1067/mai.2001.112268
- Shute, J. K. et al. Epithelial expression and release of FGF-2 from heparan sulphate binding sites in bronchial tissue in asthma. Thorax 59, 557-562 (2004). https://doi.org/10.1136/thx.2002.002626
- Chang, S. S., Yokomise, H., Matsuura, N., Gotoh, M. & Tabata, Y. Novel therapeutic approach for pulmonary emphysema using gelatin microspheres releasing basic fibroblast growth factor in a canine model. Surg. Today 44, 1536-1541 (2014). https://doi.org/10.1007/s00595-014-0864-x
- Morino, S. et al. Fibroblast growth factor-2 promotes recovery of pulmonary function in a canine models of elastase-induced emphysema. Exp. Lung Res. 33, 15-26 (2007). https://doi.org/10.1080/01902140601113070
- Morino, S. et al. Fibroblast growth factor-2 induces recovery of pulmonary blood flow in canine emphysema models. Chest 128, 920-926 (2005). https://doi.org/10.1378/chest.128.2.920
- Kawago, M. et al. Intrapleural administration of gelatin-embedded, sustainedrelease basic fibroblast growth factor for the regeneration of emphysematous lungs in rats. J. Thorac. Cardiovasc. Surg. 147, 1644-1649 (2014). https://doi.org/10.1016/j.jtcvs.2013.07.039
- Jeon, S. G. et al. Recombinant basic fibroblast growth factor inhibits the airway hyperresponsiveness, mucus production, and lung inflammation induced by an allergen challenge. J. Allergy Clin. Immunol. 119, 831-837 (2007). https://doi.org/10.1016/j.jaci.2006.12.653
- Kim, Y. S. et al. The safety and efficacy of recombinant fibroblast growth factor 2 in human asthmatics: a pilot study. Allergy Asthma Respir. Dis. 2, 200-207 (2014). https://doi.org/10.4168/aard.2014.2.3.200
- Huh, J. W. et al. Bone marrow cells repair cigarette smoke-induced emphysema in rats. Am. J. Physiol. Lung Cell. Mol. Physiol. 301, L255-L266 (2011). https://doi.org/10.1152/ajplung.00253.2010
- Kim, Y. S. et al. Extracellular vesicles, especially derived from Gram-negative bacteria, in indoor dust induce neutrophilic pulmonary inflammation associated with both Th1 and Th17 cell responses. Clin. Exp. Allergy 43, 443-454 (2013). https://doi.org/10.1111/cea.12085
- Lazarous, D. F. et al. Effects of chronic systemic administration of basic fibroblast growth factor on collateral development in the canine heart. Circulation 91, 145-153 (1995). https://doi.org/10.1161/01.CIR.91.1.145
- Schaper, W., De Brabander, M. & Lewi, P. DNA synthesis and mitoses in coronary collateral vessels of the dog. Circ. Res. 28, 671-679 (1971). https://doi.org/10.1161/01.RES.28.6.671
- Partridge, M. R. et al. Development and validation of the capacity of daily living during the morning questionnaire and the Global Chest Symptoms Questionnaire in COPD. Eur. Respir. J. 36, 96-104 (2010). https://doi.org/10.1183/09031936.00123709
- Lommatzsch, M. et al. Acute effects of tobacco smoke on human airway dendritic cells in vivo. Eur. Respir. J. 35, 1130-1136 (2010). https://doi.org/10.1183/09031936.00090109
- Costabel, U. & Guzman, J. Effect of smoking on bronchoalveolar lavage constituents. Eur. Respir. J. 5, 776-779 (1992).
- Kuschner, W. G., D'Alessandro, A., Wong, H. & Blanc, P. D. Dose-dependent cigarette smoking-related inflammatory responses in healthy adults. Eur. Respir. J. 9, 1989-1994 (1996). https://doi.org/10.1183/09031936.96.09101989
- Burke, W. M. et al. Smoking-induced changes in epithelial lining fluid volume, cell density and protein. Eur. Respir. J. 5, 780-784 (1992).
- Pardo, O. E. et al. Fibroblast growth factor-2 induces translational regulation of Bcl-XL and Bcl-2 via a MEK-dependent pathway: correlation with resistance to etoposide-induced apoptosis. J. Biol. Chem. 277, 12040-12046 (2002). https://doi.org/10.1074/jbc.M109006200
- Pardo, O. E. et al. Fibroblast growth factor 2-mediated translational control of IAPs blocks mitochondrial release of Smac/DIABLO and apoptosis in small cell lung cancer cells. Mol. Cell Biol. 23, 7600-7610 (2003). https://doi.org/10.1128/MCB.23.21.7600-7610.2003
- Aubry, M. C.,Wright, J. L. &Myers, J. L. The pathology of smoking related lung diseases. Clin. Chest Med. 21, 11-35 (2000). vii. https://doi.org/10.1016/S0272-5231(05)70005-8
- Sun, C. et al. LL-37 secreted by epithelium promotes fibroblast collagen production: a potential mechanism of small airway remodeling in chronic obstructive pulmonary disease. Lab. Invest. 94, 991-1002 (2014). https://doi.org/10.1038/labinvest.2014.86
- Kim, S. H. et al. Perceptions of severe asthma and asthma-COPD overlap syndrome among specialists: a questionnaire survey. Allergy Asthma Immunol. Res. 10, 225-235 (2018). https://doi.org/10.4168/aair.2018.10.3.225
- Krimmer, D. I., Burgess, J. K., Wooi, T. K., Black, J. L. & Oliver, B. G.Matrix proteins from smoke-exposed fibroblasts are pro-proliferative. Am. J. Respir. Cell Mol. Biol. 46, 34-39 (2012). https://doi.org/10.1165/rcmb.2010-0426OC
- Hogg, J. C. et al. The nature of small-airway obstruction in chronic obstructive pulmonary disease. N. Engl. J. Med. 350, 2645-2653 (2004). https://doi.org/10.1056/NEJMoa032158
- James, A. L. & Wenzel, S. Clinical relevance of airway remodelling in airway diseases. Eur. Respir. J. 30, 134-155 (2007). https://doi.org/10.1183/09031936.00146905
- Turner, N. & Grose, R. Fibroblast growth factor signalling: from development to cancer. Nat. Rev. Cancer 10, 116-129 (2010). https://doi.org/10.1038/nrc2780
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