과제정보
연구 과제 주관 기관 : National Nature Foundation of China, Zhejiang Provincial Natural Science Foundation of China
참고문헌
- Deyo, R. A. & Mirza, S. K. CLINICAL PRACTICE. Herniated lumbar intervertebral disk. N. Engl. J. Med. 374, 1763 (2016). https://doi.org/10.1056/NEJMcp1512658
- Vergroesen, P. P. et al. Mechanics and biology in intervertebral disc degeneration: a vicious circle. Osteoarthr. Cartil. 23, 1057-1070 (2015). https://doi.org/10.1016/j.joca.2015.03.028
- Fontana, G., See, E. & Pandit, A. Current trends in biologics delivery to restore intervertebral disc anabolism. Adv. Drug Deliv. Rev. 84, 146-158 (2015). https://doi.org/10.1016/j.addr.2014.08.008
- Dimozi, A., Mavrogonatou, E., Sklirou, A. & Kletsas, D. Oxidative stress inhibits the proliferation, induces premature senescence and promotes a catabolic phenotype in human nucleus pulposus intervertebral disc cells. Eur. Cell Mater. 30, 89-102 (2015). discussion 3. https://doi.org/10.22203/eCM.v030a07
- Chen, D. et al. Metformin protects against apoptosis and senescence in nucleus pulposus cells and ameliorates disc degeneration in vivo. Cell Death Dis. 7, e2441 (2016). https://doi.org/10.1038/cddis.2016.334
- Zhao, C. Q., Zhang, Y. H., Jiang, S. D., Jiang, L. S. & Dai, L. Y. Both endoplasmic reticulum and mitochondria are involved in disc cell apoptosis and intervertebral disc degeneration in rats. Age 32, 161-177 (2010). https://doi.org/10.1007/s11357-009-9121-4
- Blanco, F. J., Rego, I. & Ruiz-Romero, C. The role of mitochondria in osteoarthritis. Nat. Rev. Rheumatol. 7, 161-169 (2011). https://doi.org/10.1038/nrrheum.2010.213
- Osellame, L. D. & Duchen, M. R. Quality control gone wrong: mitochondria, lysosomal storage disorders and neurodegeneration. Br. J. Pharmacol. 171, 1958-1972 (2014). https://doi.org/10.1111/bph.12453
- Zhou, Y. et al. Sirt3 deficiency increased the vulnerability of pancreatic beta cells to oxidative stress-induced dysfunction. Antioxid. Redox Signal. 27, 962-976 (2017). https://doi.org/10.1089/ars.2016.6859
- Wei, T. et al. Sirtuin 3 deficiency accelerates hypertensive cardiac remodeling by impairing angiogenesis. J. Am. Heart Assoc. 6, e006114 (2017).
- Sosulski, M. L., Gongora, R., Feghali-Bostwick, C., Lasky, J. A. & Sanchez, C. G. Sirtuin 3 deregulation promotes pulmonary fibrosis. J. Gerontol. A Biol. Sci. Med. Sci. 72, 595-602 (2017).
- Shi, H. et al. Sirt3 protects dopaminergic neurons from mitochondrial oxidative stress. Hum. Mol. Genet. 26, 1915-1926 (2017). https://doi.org/10.1093/hmg/ddx100
- Salvatori, I., Valle, C., Ferri, A. & Carri, M. T. SIRT3 and mitochondrial metabolism in neurodegenerative diseases. Neurochem. Int. 109, 184 (2017). https://doi.org/10.1016/j.neuint.2017.04.012
- Dikalova, A. E. et al. Sirt3 impairment and SOD2 hyperacetylation in vascular oxidative stress and hypertension. Circ. Res. 121, 564-574 (2017). https://doi.org/10.1161/CIRCRESAHA.117.310933
- Woodbury, A., Yu, S. P., Wei, L. & Garcia, P. Neuro-modulating effects of honokiol: a review. Front. Neurol. 4, 130 (2013).
- Fried, L. E. & Arbiser, J. L. Honokiol, a multifunctional antiangiogenic and antitumor agent. Antioxid. Redox Signal. 11, 1139-1148 (2009). https://doi.org/10.1089/ars.2009.2440
- Pillai, V. B. et al. Honokiol blocks and reverses cardiac hypertrophy in mice by activating mitochondrial Sirt3. Nat. Commun. 6, 6656 (2015). https://doi.org/10.1038/ncomms7656
- General Assembly of the World Medical Association. World Medical Association Declaration of Helsinki: ethical principles for medical research involving human subjects. J. Am. Coll. Dent. 81, 14-18 (2014).
- Pfirrmann, C. W., Metzdorf, A., Zanetti, M., Hodler, J. & Boos, N. Magnetic resonance classification of lumbar intervertebral disc degeneration. Spine 26, 1873 (2001). https://doi.org/10.1097/00007632-200109010-00011
- Xu, D. et al. Hydrogen sulfide protects against endoplasmic reticulum stress and mitochondrial injury in nucleus pulposus cells and ameliorates intervertebral disc degeneration. Pharmacol. Res. 117, 357-369 (2017). https://doi.org/10.1016/j.phrs.2017.01.005
- Zeng, Z. et al. Polydatin ameliorates injury to the small intestine induced by hemorrhagic shock via SIRT3 activation-mediated mitochondrial protection. Expert. Opin. Ther. Targets 20, 645 (2016). https://doi.org/10.1080/14728222.2016.1177023
- Han, B. et al. A simple disc degeneration model induced by percutaneous needle puncture in the rat tail. Spine 33, 1925 (2008). https://doi.org/10.1097/BRS.0b013e31817c64a9
- Zemirli, N., Morel, E. & Molino, D. Mitochondrial dynamics in basal and stressful conditions. Int. J. Mol. Sci. 19, 564 (2018). https://doi.org/10.3390/ijms19020564
- Zhang, J. et al. Are sirtuins markers of ovarian aging? Gene 575, 680-686 (2016). https://doi.org/10.1016/j.gene.2015.09.043
- Wang, F., Cai, F., Shi, R., Wang, X. H. & Wu, X. T. Aging and age related stresses: a senescence mechanism of intervertebral disc degeneration. Osteoarthr. Cartil. 24, 398 (2016). https://doi.org/10.1016/j.joca.2015.09.019
- Kawamura, Y. et al. Sirt3 protects in vitro-fertilized mouse preimplantation embryos against oxidative stress-induced p53-mediated developmental arrest. J. Clin. Invest. 120, 2817 (2010). https://doi.org/10.1172/JCI42020
- Tseng, A. H., Shieh, S. S. & Wang, D. L. SIRT3 deacetylates FOXO3 to protect mitochondria against oxidative damage. Free Radic. Biol. Med. 63, 222 (2013). https://doi.org/10.1016/j.freeradbiomed.2013.05.002
- Zhou, X. et al. Resveratrol regulates mitochondrial reactive oxygen species homeostasis through Sirt3 signaling pathway in human vascular endothelial cells. Cell Death Dis. 5, e1576 (2014). https://doi.org/10.1038/cddis.2014.530
- Kim, H. S. et al. SIRT3 is a mitochondrial localized tumor suppressor required for maintenance of mitochondrial integrity and metabolism during stress. Cancer Cell. 17, 41 (2010). https://doi.org/10.1016/j.ccr.2009.11.023
- Ballinger, S. W. et al. Hydrogen peroxide- and peroxynitrite-induced mitochondrial DNA damage and dysfunction in vascular endothelial and smooth muscle cells. Circ. Res. 86, 960 (2000). https://doi.org/10.1161/01.RES.86.9.960
-
Shen, J. et al. IL-1
${\beta}$ induces apoptosis and autophagy via mitochondria pathway in human degenerative nucleus pulposus cells. Sci. Rep. 7, 41067 (2017). https://doi.org/10.1038/srep41067 - Dagda, R. K., Kulich, S. M., Tandon, A., Park, D. & Chu, C. T. Loss of PINK1 function promotes mitophagy through effects on oxidative stress and mitochondrial fission. J. Biol. Chem. 284, 13843-13855 (2009). https://doi.org/10.1074/jbc.M808515200
- Frank, M. et al. Mitophagy is triggered by mild oxidative stress in a mitochondrial fission dependent manner. Biochim. Biophys. Acta Mol. Cell Res. 1823, 2297-2310 (2012). https://doi.org/10.1016/j.bbamcr.2012.08.007
- Sengupta, S. et al. Activation of tumor suppressor LKB1 by honokiol abrogates cancer stem-like phenotype in breast cancer via inhibition of oncogenic Stat3. Oncogene 36, 5709-5721 (2017). https://doi.org/10.1038/onc.2017.164
피인용 문헌
- Reciprocal Regulation of TRPS1 and miR-221 in Intervertebral Disc Cells vol.8, pp.10, 2018, https://doi.org/10.3390/cells8101170
- Allicin Attenuated Advanced Oxidation Protein Product-Induced Oxidative Stress and Mitochondrial Apoptosis in Human Nucleus Pulposus Cells vol.2020, pp.None, 2020, https://doi.org/10.1155/2020/6685043
- Mitochondrial Dysfunction in Intervertebral Disc Degeneration: From Pathogenesis to Therapeutic Target vol.2020, pp.None, 2020, https://doi.org/10.1155/2020/8880320
- Promoting Nrf2/Sirt3-Dependent Mitophagy Suppresses Apoptosis in Nucleus Pulposus Cells and Protects against Intervertebral Disc Degeneration vol.2021, pp.None, 2021, https://doi.org/10.1155/2021/6694964
- Natural Products of Pharmacology and Mechanisms in Nucleus Pulposus Cells and Intervertebral Disc Degeneration vol.2021, pp.None, 2018, https://doi.org/10.1155/2021/9963677
- RNA‐binding protein HuR suppresses senescence through Atg7 mediated autophagy activation in diabetic intervertebral disc degeneration vol.54, pp.2, 2018, https://doi.org/10.1111/cpr.12975
- AMPK as a Potential Therapeutic Target for Intervertebral Disc Degeneration vol.8, pp.None, 2018, https://doi.org/10.3389/fmolb.2021.789087
- Stem Cells and Exosomes: New Therapies for Intervertebral Disc Degeneration vol.10, pp.9, 2018, https://doi.org/10.3390/cells10092241