Journal of Microbiology and Biotechnology

The Korean Society for Microbiology and Biotechnology (한국미생물·생명공학회)
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Decursin and Z-Ligustilide in Angelica tenuissima Root Extract Fermented by Aspergillus oryzae Display Anti-Pigment Activity in Melanoma Cells

  • Park, Yuna (College of Health Science, Kangwon National University) ;
  • Kim, Dayoung (Department of Chemistry and Nano Science, Global Top 5 Program, Ewha Womans University) ;
  • Yang, Inho (Department of Convergence Study on the Ocean Science and Technology, Korea Maritime and Ocean University) ;
  • Choi, Bomee (Department of Chemistry and Nano Science, Global Top 5 Program, Ewha Womans University) ;
  • Lee, Jin Woo (College of Health Science, Kangwon National University) ;
  • Namkoong, Seung (College of Health Science, Kangwon National University) ;
  • Koo, Hyun Jung (Department of Medicinal and Industrial Crops, Korea National College of Agriculture and Fisheries) ;
  • Lee, Sung Ryul (Department of Convergence Biomedical Science, Cardiovascular and Metabolic Disease Center, College of Medicine, Inje University) ;
  • Park, Myung Rye (Korea Research Institute Bio Science Co., Ltd.) ;
  • Lim, Hyosun (Korea Research Institute Bio Science Co., Ltd.) ;
  • Kim, Youn Kyu (Korea Research Institute Bio Science Co., Ltd.) ;
  • Nam, Sang-Jip (Department of Chemistry and Nano Science, Global Top 5 Program, Ewha Womans University) ;
  • Sohn, Eun-Hwa (College of Health Science, Kangwon National University)
  • Received : 2018.02.26
  • Accepted : 2018.04.11
  • Published : 2018.07.28
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Abstract

The anti-melanogenic effects of the extract of Angelica tenuissima (AT) root and the extract of AT root fermented by Aspergillus oryzae (FAT) were investigated. These effects were determined by measuring the inhibitory activity of AT and FAT on melanin production in B16F10 melanocytes and with in vitro tyrosinase activity assays. The AT extract inhibited melanin production at concentrations above $250{\mu}g/ml$, and this inhibitory effect was significantly enhanced by the fermentation process with A. oryzae. HPLC analysis resulted in the isolation of two active compounds from both the AT and FAT extracts. Their chemical structures were identified as decursin and Z-ligustilide through comparison with previously reported NMR data. The decursin and Z-ligustilide contents were increased in the FAT extract and could be responsible for its enhanced inhibitory effects on melanin production and tyrosinase activity compared with that of the AT extract.

Keywords

References

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