BMB Reports

생화학분자생물학회 (Korean Society for Biochemistry and Molecular Biology)
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Activation of formyl peptide receptor 2 by WKYMVm enhances emergency granulopoiesis through phospholipase C activity

  • Kim, Hyung Sik (Department of Biological Sciences, Sungkyunkwan University) ;
  • Park, Min Young (Department of Biological Sciences, Sungkyunkwan University) ;
  • Lee, Sung Kyun (Department of Biological Sciences, Sungkyunkwan University) ;
  • Park, Joon Seong (Department of Hematology-Oncology, Ajou University School of Medicine) ;
  • Lee, Ha Young (Department of Biological Sciences, Sungkyunkwan University) ;
  • Bae, Yoe-Sik (Department of Biological Sciences, Sungkyunkwan University)
  • 투고 : 2018.04.13
  • 심사 : 2018.07.03
  • 발행 : 2018.08.31
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초록

Emergency granulopoiesis is a very important strategy to supply efficient neutrophil number in response to infection. However, molecular mechanism involved in this process remains unclear. Here, we found that administration of WKYMVm, an immune modulating peptide, to septic mice strongly increased neutrophil number through augmented emergency granulopoiesis. WKYMVm-induced emergency granulopoiesis was blocked not only by a formyl peptide receptor 2 (FPR2) antagonist (WRW4), but also by FPR2 deficiency. As progenitors of neutrophils, $Lin^-c-kit^+Sca-1^-$ cells expressed FPR2. WKYMVm-induced emergency granulopoiesis was also blocked by a phospholipase C inhibitor (U-73122). These results suggest that WKYMVm can stimulate emergency granulopoiesis via FPR2 and phospholipase C enzymatic activity.

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참고문헌

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