BMB Reports
- 제51권8호
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- Pages.371-372
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- 2018
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- 1976-670X(eISSN)
DOI QR Code
Dyslipidemia promotes germinal center reactions via IL-27
- Ryu, Heeju (Laboratory of Immune Regulation, Institute of Pharmaceutical Sciences, Seoul National University) ;
- Chung, Yeonseok (Laboratory of Immune Regulation, Institute of Pharmaceutical Sciences, Seoul National University)
- 투고 : 2018.07.07
- 발행 : 2018.08.31
초록
Cardiovascular disease such as atherosclerosis is caused by imbalanced lipid metabolism and represents a leading cause of death worldwide. Epidemiological studies show that patients with systemic autoimmune diseases exhibit a higher incidence of atherosclerosis. Conversely, hyperlipidemia has been known to accelerate the incidence of autoimmune diseases in humans and in animal models. However, there is a considerable gap in our understanding of how atherosclerosis impacts the development of the autoimmunity in humans, and vice versa. The atherosclerosis-related autoimmune diseases include psoriasis, rheumatoid arthritis, systemic lupus erythematosus (SLE) and diabetes mellitus. By using animal models of atherosclerosis and SLE, we have recently demonstrated that hyperlipidemia significantly accelerates the development of autoantibodies, by inducing autoimmune follicular helper T (