DOI QR코드

DOI QR Code

Clinical Characteristics, Presentation, and Outcomes of Bronchopulmonary Dysplasia-Associated Pulmonary Hypertension

  • Kim, Do-Hyun (Department of Pediatrics, Dongguk University Ilsan Hospital, Dongguk University College of Medicine) ;
  • Kim, Han-Suk (Department of Pediatrics, Seoul National University College of Medicine)
  • 투고 : 2018.07.10
  • 심사 : 2018.08.21
  • 발행 : 2018.08.31

초록

Bronchopulmonary dysplasia-associated pulmonary hypertension (BPD-PH) is increasingly being recognized as a cause of morbidity and mortality in preterm infants. Recently, BPD-PH has also been shown to have additional long-term negative effects on neurodevelopmental outcomes and right ventricular function. Several significant risk factors associated with the development of BPD-PH have been identified. A screening strategy for BPD-PH is needed for infants presenting more than one risk factor. In addition, an early echocardiogram within 14 days of age may be a useful tool to identify infants at high-risk for BPD-PH. We have reviewed recent progress in research concerning clinical characteristics, presentation, and outcomes of BPD-PH and have suggested direction for future studies.

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참고문헌

  1. Mourani PM, Abman SH. Pulmonary vascular disease in bronchopulmonary dysplasia: pulmonary hypertension and beyond. Curr Opin Pediatr 2013;25:329-37. https://doi.org/10.1097/MOP.0b013e328360a3f6
  2. Kim DH. Pathophysiology and risk factors of pulmonary hypertension in infants with bronchopulmonary dysplasia. Korean J Perinatol 2014;25:1-8. https://doi.org/10.14734/kjp.2014.25.1.1
  3. An HS, Bae EJ, Kim GB, Kwon BS, Beak JS, Kim EK, et al. Pulmonary hypertension in preterm infants with bronchopulmonary dysplasia. Korean Circ J 2010;40:131-6. https://doi.org/10.4070/kcj.2010.40.3.131
  4. Slaughter JL, Pakrashi T, Jones DE, South AP, Shah TA. Echocardiographic detection of pulmonary hypertension in extremely low birth weight infants with bronchopulmonary dysplasia requiring prolonged positive pressure ventilation. J Perinatol 2011;31:635-40. https://doi.org/10.1038/jp.2010.213
  5. Kim DH, Kim HS, Choi CW, Kim EK, Kim BI, Choi JH. Risk factors for pulmonary artery hypertension in preterm infants with moderate or severe bronchopulmonary dysplasia. Neonatology 2012;101:40-6. https://doi.org/10.1159/000327891
  6. Bhat R, Salas AA, Foster C, Carlo WA, Ambalavanan N. Prospective analysis of pulmonary hypertension in extremely low birth weight infants. Pediatrics 2012;129:e682-9. https://doi.org/10.1542/peds.2011-1827
  7. Mourani PM, Abman SH. Pulmonary hypertension and vascular abnormalities in bronchopulmonary dysplasia. Clin Perinatol 2015;42:839-55. https://doi.org/10.1016/j.clp.2015.08.010
  8. Mourani PM, Sontag MK, Younoszai A, Miller JI, Kinsella JP, Baker CD, et al. Early pulmonary vascular disease in preterm infants at risk for bronchopulmonary dysplasia. Am J Respir Crit Care Med 2015;191:87-95. https://doi.org/10.1164/rccm.201409-1594OC
  9. Arjaans S, Zwart EAH, Ploegstra MJ, Bos AF, Kooi EMW, Hillege HL, et al. Identification of gaps in the current knowledge on pulmonary hypertension in extremely preterm infants: a systematic review and meta-analysis. Paediatr Perinat Epidemiol 2018;32:258-67. https://doi.org/10.1111/ppe.12444
  10. Khemani E, McElhinney DB, Rhein L, Andrade O, Lacro RV, Thomas KC, et al. Pulmonary artery hypertension in formerly premature infants with bronchopulmonary dysplasia: clinical features and outcomes in the surfactant era. Pediatrics 2007;120:1260-9. https://doi.org/10.1542/peds.2007-0971
  11. Kumar VH, Hutchison AA, Lakshminrusimha S, Morin FC 3rd, Wynn RJ, Ryan RM. Characteristics of pulmonary hypertension in preterm neonates. J Perinatol 2007;27:214-9. https://doi.org/10.1038/sj.jp.7211673
  12. Al-Ghanem G, Shah P, Thomas S, Banfield L, El Helou S, Fusch C, et al. Bronchopulmonary dysplasia and pulmonary hypertension: a meta-analysis. J Perinatol 2017;37:414-9. https://doi.org/10.1038/jp.2016.250
  13. Nakanishi H, Uchiyama A, Kusuda S. Impact of pulmonary hypertension on neurodevelopmental outcome in preterm infants with bronchopulmonary dysplasia: a cohort study. J Perinatol 2016;36:890-6. https://doi.org/10.1038/jp.2016.108
  14. Kwon HW, Kim HS, An HS, Kwon BS, Kim GB, Shin SH, et al. Long-term outcomes of pulmonary hypertension in preterm infants with bronchopulmonary dysplasia. Neonatology 2016;110:181-9. https://doi.org/10.1159/000445476
  15. del Cerro MJ, Sabate Rotes A, Carton A, Deiros L, Bret M, Cordeiro M, et al. Pulmonary hypertension in bronchopulmonary dysplasia: clinical findings, cardiovascular anomalies and outcomes. Pediatr Pulmonol 2014;49:49-59. https://doi.org/10.1002/ppul.22797
  16. Abman SH, Hansmann G, Archer SL, Ivy DD, Adatia I, Chung WK, et al. Pediatric pulmonary hypertension: guidelines from the American Heart Association and American Thoracic Society. Circulation 2015;132:2037-99. https://doi.org/10.1161/CIR.0000000000000329
  17. Nagiub M, Kanaan U, Simon D, Guglani L. Risk factors for development of pulmonary hypertension in infants with bronchopulmonary dysplasia: systematic review and meta-analysis. Paediatr Respir Rev 2017;23:27-32.
  18. Mirza H, Ziegler J, Ford S, Padbury J, Tucker R, Laptook A. Pulmonary hypertension in preterm infants: prevalence and association with bronchopulmonary dysplasia. J Pediatr 2014;165:909-14. https://doi.org/10.1016/j.jpeds.2014.07.040
  19. Berenz A, Vergales JE, Swanson JR, Sinkin RA. Evidence of early pulmonary hypertension is associated with increased mortality in very low birth weight infants. Am J Perinatol 2017;34:801-7. https://doi.org/10.1055/s-0037-1598246
  20. Kim SY, Shin SH, Kim HS, Jung YH, Kim EK, Choi JH. Pulmonary arterial hypertension after ibuprofen treatment for patent ductus arteriosus in very low birth weight infants. J Pediatr 2016;179:49-53. https://doi.org/10.1016/j.jpeds.2016.08.103
  21. Kim DH, Shin SH, Kim EK, Kim HS. Association of increased cord blood soluble endoglin with the development of bronchopulmonary dysplasia in preterm infants with maternal preeclampsia. Pregnancy Hypertens 2018;13:148-53. https://doi.org/10.1016/j.preghy.2018.06.002
  22. Kim DH, Kim HS. Serial changes of serum endostatin and angiopoietin-1 levels in preterm infants with severe bronchopulmonary dysplasia and subsequent pulmonary artery hypertension. Neonatology 2014;106:55-61. https://doi.org/10.1159/000358374
  23. Robbins IM, Moore TM, Blaisdell CJ, Abman SH. National Heart, Lung, and Blood Institute Workshop: improving outcomes for pulmonary vascular disease. Circulation 2012;125:2165-70. https://doi.org/10.1161/CIRCULATIONAHA.112.092924