The Korean journal of internal medicine

  • 제33권5호
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  • Pages.1016-1024
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  • 2018
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  • 1226-3303(pISSN)
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  • 2005-6648(eISSN)
대한내과학회 (The Korean Association of Internal Medicine)
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Isoniazid treatment for latent tuberculosis infection is tolerable for rheumatoid arthritis patients receiving tumor necrosis factor inhibitor therapy

  • Sung, Yoon-Kyoung (Department of Rheumatology, Hospital for Rheumatic Diseases, Hanyang University Medical Center) ;
  • Cho, Soo-Kyung (Department of Rheumatology, Hospital for Rheumatic Diseases, Hanyang University Medical Center) ;
  • Kim, Dam (Department of Rheumatology, Hospital for Rheumatic Diseases, Hanyang University Medical Center) ;
  • Won, Soyoung (Clinical Research Center for Rheumatoid Arthritis) ;
  • Choi, Chan-Bum (Department of Rheumatology, Hospital for Rheumatic Diseases, Hanyang University Medical Center) ;
  • Kim, Tae-Hwan (Department of Rheumatology, Hospital for Rheumatic Diseases, Hanyang University Medical Center) ;
  • Jun, Jae-Bum (Department of Rheumatology, Hospital for Rheumatic Diseases, Hanyang University Medical Center) ;
  • Yoo, Dae-Hyun (Department of Rheumatology, Hospital for Rheumatic Diseases, Hanyang University Medical Center) ;
  • Bae, Sang-Cheol (Department of Rheumatology, Hospital for Rheumatic Diseases, Hanyang University Medical Center)
  • 투고 : 2016.07.04
  • 심사 : 2016.09.13
  • 발행 : 2018.09.01
⟨ 이전 논문 다음 논문 ⟩

초록

Background/Aims: To evaluate the impact of isoniazid (INH) treatment for latent tuberculosis infection (LTBI) on the development of liver function test (LFT) abnormality and the persistence of tumor necrosis factor (TNF) inhibitors in rheumatoid arthritis (RA) patients. Methods: We retrospectively enrolled patients with RA who were treated with TNF inhibitors at a university hospital between December 2000 and November 2011. After dividing the patients into two groups based on the occurrence of LFT abnormality during follow-up, we compared demographic and clinical features between the two groups. A multivariable logistic regression analysis was performed to identify the impact of INH treatment on LFT abnormality. The impact of INH treatment on the persistence of TNF inhibitors was also evaluated with the log-rank test and the Cox-proportional hazards model. Results: A total of 312 RA patients including 96 patients (30.9%) who took INH for LTBI were included in this analysis. Thirty-nine patients (12.5%) experienced LFT abnormalities while using TNF inhibitors. The use of INH was associated with LFT abnormalities (odds ratio, 3.01; 95% confidence interval [CI], 1.39 to 6.48) after adjusting for covariates, including methotrexate use. However, the persistence of TNF inhibitors over 5 years did not differ between patients receiving or not receiving INH treatment (49.4 vs. 54.6%, p = 0.79). INH treatment was not a risk factor for discontinuation of TNF inhibitors (hazard ratio, 1.01; 95% CI, 0.66 to 1.57). Conclusion: INH treatment for LTBI in RA patients who started TNF inhibitors is associated with the occurrence of LFT abnormality; however, it does not lead to discontinuation of TNF inhibitors.

키워드

과제정보

연구 과제 주관 기관 : Korea Health Industry Development Institute (KHIDI)

참고문헌

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피인용 문헌

  1. Isoniazid/tumor necrosis factor inhibitors : Abnormal liver function test: case report vol.1723, pp.1, 2018, https://doi.org/10.1007/s40278-018-52863-x
  2. Risk of Tuberculosis Development in Patients with Rheumatoid Arthritis Receiving Targeted Therapy: a Prospective Single Center Cohort Study vol.36, pp.10, 2021, https://doi.org/10.3346/jkms.2021.36.e70