The Korean journal of internal medicine

The Korean Association of Internal Medicine (대한내과학회)
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Management of carbapenem-resistant Acinetobacter baumannii epidemic in an intensive care unit using multifaceted intervention strategy

  • Hong, Jeongmin (Department of Internal Medicine, Gyeongsang National University Hospital) ;
  • Jang, Ok Jeom (Infection Control Office, Gyeongsang National University Hospital) ;
  • Bak, Mi Hui (Infection Control Office, Gyeongsang National University Hospital) ;
  • Baek, Eun Hwa (Infection Control Office, Gyeongsang National University Hospital) ;
  • Park, Ki-Ho (Department of Internal Medicine, Kyung Hee University Hospital) ;
  • Hong, Sun In (Department of Internal Medicine, Gyeongsang National University Changwon Hospital) ;
  • Cho, Oh-Hyun (Department of Internal Medicine, Gyeongsang National University Hospital) ;
  • Bae, In-Gyu (Department of Internal Medicine, Gyeongsang National University Hospital)
  • Received : 2016.10.08
  • Accepted : 2017.01.15
  • Published : 2018.09.01
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Abstract

Background/Aims: We evaluated the effects of a multifaceted intervention for controlling a carbapenem-resistant Acinetobacter baumannii (CRAB) epidemic in an intensive care unit (ICU) with no restrictions on carbapenem use. Methods: This study was conducted in a medical ICU between April 2012 and June 2016. The baseline infection control programs included surveillance cultures, contact precautions, and environmental cleaning. However, increases in the detection of CRAB isolates beginning in May 2013 led to the implementation of a new protocol, consisting of universal glove and gown use with daily chlorhexidine bathing for all patients in combination with baseline programs. The efficacy of the intervention was subjected to interrupted time series (ITS) analysis. Results: The multifaceted intervention led to a decrease in the incidence of CRAB from 17.65 to 0.89 cases per 1,000 patient-days, during the study period (p < 0.001). ITS analysis revealed a significant change in the trend of CRAB incidence (-0.413, p < 0.001). Over this same period, mean monthly use of carbapenems increased from $143.54{\pm}95.73$ to $204.95{\pm}78.43$ doses per 1,000 patient-days (p = 0.018). Conclusions: Our multifaceted intervention reduced the incidence of CRAB acquisition in an ICU where carbapenem use was not restricted.

Keywords

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