Journal of Veterinary Clinics (한국임상수의학회지)

The Korean Society of Veterinary Clinics (한국임상수의학회)
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Glyphosate Surfactant Herbicide Toxicosis in a Dog with Hindlimb Paresis and Urinary Incontinence

  • Lee, Ga-won (Department of Veterinary Internal Medicine, College of Veterinary Medicine, Konkuk University) ;
  • Ro, Woong-bin (Department of Veterinary Internal Medicine, College of Veterinary Medicine, Konkuk University) ;
  • Kang, Min-hee (Department of Veterinary Internal Medicine, College of Veterinary Medicine, Konkuk University)
  • Published : 2018.08.31
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Abstract

A 4-year-old Yorkshire terrier was presented with hindlimb paresis and urinary incontinence after accidental ingestion of an herbicide. Based on neurologic examinations, decreased hindlimb proprioception with flaccid paresis were revealed. Other possible causes of the clinical signs were excluded. The clinical signs gradually improved after administration of anti-inflammatory and antioxidant therapy. This case report is the first to describe the long-term outcome of hindlimb paresis and urinary incontinence induced by glyphosate surfactant herbicide (GPSH) poisoning in a dog.

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References

  1. Anadon A, Martinez-Larranaga MR, Martinez MA, Castellano VJ, Martinez M, Martin MT, Nozal MJ, Bernal JL. Toxicokinetics of glyphosate and its metabolite aminomethyl phosphonic acid in rats. Toxicol Lett. 2009; 190: 91-5. https://doi.org/10.1016/j.toxlet.2009.07.008
  2. Cortinovis C, Davanzo F, Rivolta M, Caloni F. Glyphosatesurfactant herbicide poisoning in domestic animals: an epidemiological survey. Vet Rec. 2015; 176: 413.
  3. Garlich FM, Goldman M, Pepe J, Nelson LS, Allan MJ, Goldstein DA, Goldfarb DS, Hoffman RS. Hemodialysis clearance of glyphosate following a life-threatening ingestion of glyphosate-surfactant herbicide. Clin Toxicol (Phila). 2014; 52: 66-71. https://doi.org/10.3109/15563650.2013.870344
  4. Han J, Moon H, Hong Y, Yang S, Jeong WJ, Lee KS, Chung H. Determination of glyphosate and its metabolite in emergency room in Korea. Forensic Sci Int. 2016; 265: 41-6. https://doi.org/10.1016/j.forsciint.2015.12.049
  5. Kim YH, Lee JH, Cho KW, Lee DW, Kang MJ, Lee KY, Lee YH, Hwang SY, Lee NK. Prognostic Factors in Emergency Department Patients with Glyphosate Surfactant Intoxication: Point-of-Care Lactate Testing. Basic Clin Pharmacol Toxicol. 2016; 119: 604-610. https://doi.org/10.1111/bcpt.12624
  6. Kim YH, Lee JH, Hong CK, Cho KW, Park YH, Kim YW, Hwang SY. Heart rate-corrected QT interval predicts mortality in glyphosate-surfactant herbicide-poisoned patients. Am J Emerg Med. 2014; 32: 203-7. https://doi.org/10.1016/j.ajem.2013.09.025
  7. Mahendrakar K, Venkategowda PM, Rao SM, Mutkule DP. Glyphosate surfactant herbicide poisoning and management. Indian J Crit Care Med. 2014; 18: 328-30. https://doi.org/10.4103/0972-5229.132508
  8. Moon JM, Chun BJ. Predicting acute complicated glyphosate intoxication in the emergency department. Clin Toxicol (Phila). 2010; 48: 718-24. https://doi.org/10.3109/15563650.2010.488640
  9. Plumlee KH. Clinical veterinary toxicology, 1st ed. St. Louis (MO): Mosby. 2004: 162-163.
  10. Roberts DM, Buckley NA, Mohamed F, Eddleston M, Goldstein DA, Mehrsheikh A, Bleeke MS, Dawson AH. A prospective observational study of the clinical toxicology of glyphosate-containing herbicides in adults with acute selfpoisoning. Clin Toxicol (Phila). 2010; 48: 129-36. https://doi.org/10.3109/15563650903476491