Pediatric Infection and Vaccine

The Korean Society of Pediatric Infectious Diseases (대한소아감염학회)
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Recurrent Familial Furunculosis Associated with Panton-Valentine Leukocidin-Positive Methicillin-Susceptible Staphylococcus aureus ST1

  • Lee, Jin Young (Department of Internal Medicine, Kosin University College of Medicine) ;
  • Park, Ji Young (Department of Internal Medicine, Kosin University Gospel Hospital) ;
  • Bae, Il Kwon (Department of Dental Hygiene, College of Health and Welfare, Silla University) ;
  • Jeong, Seri (Department of Laboratory Medicine, Kosin University College of Medicine) ;
  • Park, Ji Hyun (Department of Pediatrics, Kosin University College of Medicine) ;
  • Jin, Sol (Department of Internal Medicine, Kosin University College of Medicine)
  • Received : 2017.12.14
  • Accepted : 2018.03.05
  • Published : 2018.08.25
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Abstract

Staphylococcus aureus is now a major community-acquired pathogen worldwide, notably associated with skin and soft tissue infections. Staphylococci are present in the form of colonizers or environmental contaminants at home and increase the risk of recurrent infection. We are describing recurrent familial furunculosis caused by Panton-Valentine Leukocidin-positive methicillin susceptible S. aureus ST1 in Korea. An infant, his father and mother had furunculosis due to methicillin-sensitive S. aureus (MSSA) infection with identical susceptibility patterns. ST1 accounted for all 3 isolates and they were confirmed of having agr group I. Both sec and seh were detected in all isolates using polymerase chain reaction (PCR) assays, and all isolates contained Panton-Valentine leukocidin (PVL) genes. Risk factors for the household spread of S. aureus include skin conditions and close physical contact among household members. The relationship between S. aureus colonization of household contacts and the occurrence of S. aureus infection should be studied into more detail.

포도알균은 피부 및 연조직 감염과 관련된 병원체로 재발 감염의 위험이 높다. 저자들은 국내에서 Panton-Valentine leukocidin (PVL) 양성 메티실린 감수성 포도알균 ST1에 의한 가족 내 재발성 종기를 경험하였으며, 16개월의 남자 환아와 아버지, 어머니의 종기에서 획득한 검체는 모두 동일한 항생제 감수성을 보였다. 세 환자의 균주 모두 agr 그룹으로 확인되었고, polymerase chain reaction (PCR) 검사에서 sec, seh가 확인되었으며 PVL 유전자를 포함하고 있었다. 가족 내 신체 접촉으로 인한 포도알균의 전파 가능성 및 예방에 대한 고려를 해 볼 필요가 있다.

Keywords

References

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