The Journal of Korean Medicine (대한한의학회지)

The Society of Korean Medicine (대한한의학회)
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Study of Efficacy and Safety of Ginseng Seed Oil in Heathy Subjects Who Have Mild Liver Dysfunction : A Randomized, Double Blinded, Placebo-Controlled Study

경증의 간 기능 이상 소견을 보이는 건강한 성인에 대한 인삼종자오일의 유효성 및 안전성 연구 : 무작위배정, 이중눈가림, 위약대조 연구

  • Kim, Young-Ji (Dep. of Korean Internal Medicine, College of Korean Medicine, Semyung University) ;
  • Kwon, Jung-Yeon (Dep. of Korean Internal Medicine, College of Korean Medicine, Semyung University) ;
  • Go, Ho-Yeon (Dep. of Korean Internal Medicine, College of Korean Medicine, Semyung University) ;
  • Lee, Dong-Nyung (Dep. of Korean Gynecology, College of Korean Medicine, Semyung University) ;
  • Ko, Sung-Kwon (Dept. of Oriental Medical Food & Nutrition, Semyung University) ;
  • Kong, Kyung-Hwan (Dep. of Korean Internal Medicine, College of Korean Medicine, Semyung University)
  • 김영지 (세명대학교 한의과대학 한방내과학교실) ;
  • 권정연 (세명대학교 한의과대학 한방내과학교실) ;
  • 고호연 (세명대학교 한의과대학 한방내과학교실) ;
  • 이동녕 (세명대학교 한의과대학 한방부인과학교실) ;
  • 고성권 (세명대학교 한방식품영양학부) ;
  • 공경환 (세명대학교 한의과대학 한방내과학교실)
  • Received : 2018.05.28
  • Accepted : 2018.06.08
  • Published : 2018.06.30
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Abstract

Objectives: The purpose of this study was to investigate the effectiveness and safety of ginseng seed oil in healthy subjects who have mild liver dysfunction. Methods: A randomized, double blinded, placebo-controlled trial was conducted. A total of 167 subjects visited Semyung University Hospital from July 1st, 2016 to June 10th 2017. Except for the 103 excluded subjects, 64 subjects were randomized into one of the two groups: an treatment group(n=33) and control group(n=31). Subjects were randomly given either ginseng oil seed capsules or indistinguishable placebo capsules(2 capsules per dose, twice per day). Laboratory tests(aspartate aminotransferase, alanine aminotransferase, gamma glutamyl transpeptidase, triglyceride, total cholesterol, high density lipoprotein-cholesterol, low density lipoprotein-cholesterol) were performed to evaluate the effectiveness after 6, 12 weeks of treatment. Vital sign, laboratory test were performed to assess safety at every visit. Results: There were no significant differences in efficacy between treatment group and control group. There were some adverse events with no significant difference in symptoms and frequency between treatment group and control group. Conclusions: Although the efficacy of ginseng seed oil was not proved, ginseng seed oil did not worsen liver function and proved its safety. More study of ginseng seed oil and clinical trials are necessary to increase the usefulness of above-ground parts of ginseng.

Keywords

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