DOI QR코드

DOI QR Code

Endoscopic Features of Mucous Cap Polyps: A Way to Predict Serrated Polyps

  • Moy, Brian T. (Division of Gastroenterology and Hepatology, UConn Health) ;
  • Forouhar, Faripour (Department of Pathology, UConn Health) ;
  • Kuo, Chia-Ling (Connecticut Institute for Clinical & Translational Science, UConn Health) ;
  • Devers, Thomas J. (Division of Gastroenterology and Hepatology, UConn Health)
  • 투고 : 2017.09.20
  • 심사 : 2017.11.20
  • 발행 : 2018.07.30

초록

Background/Aims: The aims of the study were to identify whether a mucous-cap predicts the presence of serrated polyps, and to determine whether additional endoscopic findings predict the presence of a sessile serrated adenomas/polyp (SSA/P). Methods: We analyzed 147 mucous-capped polyps with corresponding histology, during 2011-2014. Eight endoscopic features (presence of borders, elevation, rim of debris, location in the colon, size ${\geq}10mm$, varicose vessels, nodularity, and alteration in mucosal folds) of mucous-capped polyps were examined to see if they can predict SSA/Ps. Results: A total of 86% (n=126) of mucous-capped polyps were from the right sided serrated pathway (right-sided hyperplastic [n=83], SSA/Ps [n=43], traditional serrated adenoma [n=1]), 10% (n=15) were left-sided hyperplastic polyps, and 3% (n=5) were from the adenoma-carcinoma sequence. The presence of a mucous cap combined with varicose vessels was the only significant predictor for SSA/Ps. The other seven characteristics were not found to be statistically significant for SSA/Ps, although location in the colon and the presence of nodularity trended towards significance. Conclusions: Our study suggests that mucous-capped polyps have high predictability for being a part of the serrated pathway. Gastroenterologists should be alert for a mucous-capped polyp with varicose veins, as these lesions have a higher risk of SSA/P.

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참고문헌

  1. Vogelstein B, Fearon ER, Hamilton SR, et al. Genetic alterations during colorectal-tumor development. N Engl J Med 1988;319:525-532. https://doi.org/10.1056/NEJM198809013190901
  2. Sillars-Hardebol AH, Carvalho B, van Engeland M, Fijneman RJ, Meijer GA. The adenoma hunt in colorectal cancer screening: defining the target. J Pathol 2012;226:1-6. https://doi.org/10.1002/path.3012
  3. East JE, Saunders BP, Jass JR. Sporadic and syndromic hyperplastic polyps and serrated adenomas of the colon: classification, molecular genetics, natural history, and clinical management. Gastroenterol Clin North Am 2008;37:25-46, v. https://doi.org/10.1016/j.gtc.2007.12.014
  4. Arnold CA, Montgomery E, Iacobuzio-Donahue CA. The serrated pathway of neoplasia: new insights into an evolving concept. Diagn Histopathol (Oxf) 2011;17:367-375. https://doi.org/10.1016/j.mpdhp.2011.06.006
  5. Leggett B, Whitehall V. Role of the serrated pathway in colorectal cancer pathogenesis. Gastroenterology 2010;138:2088-2100. https://doi.org/10.1053/j.gastro.2009.12.066
  6. Torlakovic E, Skovlund E, Snover DC, Torlakovic G, Nesland JM. Morphologic reappraisal of serrated colorectal polyps. Am J Surg Pathol 2003;27:65-81. https://doi.org/10.1097/00000478-200301000-00008
  7. Tadepalli US, Feihel D, Miller KM, et al. A morphologic analysis of sessile serrated polyps observed during routine colonoscopy (with video). Gastrointest Endosc 2011;74:1360-1368. https://doi.org/10.1016/j.gie.2011.08.008
  8. Bressler B, Paszat LF, Chen Z, Rothwell DM, Vinden C, Rabeneck L. Rates of new or missed colorectal cancers after colonoscopy and their risk factors: a population-based analysis. Gastroenterology 2007;132:96-102. https://doi.org/10.1053/j.gastro.2006.10.027
  9. Baxter NN, Goldwasser MA, Paszat LF, Saskin R, Urbach DR, Rabeneck L. Association of colonoscopy and death from colorectal cancer. Ann Intern Med 2009;150:1-8. https://doi.org/10.7326/0003-4819-150-1-200901060-00306
  10. Hetzel JT, Huang CS, Coukos JA, et al. Variation in the detection of serrated polyps in an average risk colorectal cancer screening cohort. Am J Gastroenterol 2010;105:2656-2664. https://doi.org/10.1038/ajg.2010.315
  11. de Wijkerslooth TR, Stoop EM, Bossuyt PM, et al. Differences in proximal serrated polyp detection among endoscopists are associated with variability in withdrawal time. Gastrointest Endosc 2013;77:617-623. https://doi.org/10.1016/j.gie.2012.10.018
  12. Kahi CJ, Hewett DG, Norton DL, Eckert GJ, Rex DK. Prevalence and variable detection of proximal colon serrated polyps during screening colonoscopy. Clin Gastroenterol Hepatol 2011;9:42-46. https://doi.org/10.1016/j.cgh.2010.09.013
  13. Pohl H, Srivastava A, Bensen SP, et al. Incomplete polyp resection during colonoscopy-results of the complete adenoma resection (CARE) study. Gastroenterology 2013;144:74-80.e1. https://doi.org/10.1053/j.gastro.2012.09.043
  14. Murakami T, Sakamoto N, Ritsuno H, et al. Distinct endoscopic characteristics of sessile serrated adenoma/polyp with and without dysplasia/carcinoma. Gastrointest Endosc 2017;85:590-600. https://doi.org/10.1016/j.gie.2016.09.018
  15. Parente F, Marino B, Crosta C. Bowel preparation before colonoscopy in the era of mass screening for colo-rectal cancer: a practical approach. Dig Liver Dis 2009;41:87-95. https://doi.org/10.1016/j.dld.2008.06.005
  16. Chiu HM, Lin JT, Lee YC, et al. Different bowel preparation schedule leads to different diagnostic yield of proximal and nonpolypoid colorectal neoplasm at screening colonoscopy in average-risk population. Dis Colon Rectum 2011;54:1570-1577. https://doi.org/10.1097/DCR.0b013e318231d667
  17. Harewood GC, Sharma VK, de Garmo P. Impact of colonoscopy preparation quality on detection of suspected colonic neoplasia. Gastrointest Endosc 2003;58:76-79. https://doi.org/10.1067/mge.2003.294
  18. Pereyra L, Gomez EJ, Gonzalez R, et al. Finding sessile serrated adenomas: is it possible to identify them during conventional colonoscopy? Dig Dis Sci 2014;59:3021-3026. https://doi.org/10.1007/s10620-014-3295-z
  19. Rustagi T, Rangasamy P, Myers M, et al. Sessile serrated adenomas in the proximal colon are likely to be flat, large and occur in smokers. World J Gastroenterol 2013;19:5271-5277. https://doi.org/10.3748/wjg.v19.i32.5271
  20. Bauer VP, Papaconstantinou HT. Management of serrated adenomas and hyperplastic polyps. Clin Colon Rectal Surg 2008;21:273-279. https://doi.org/10.1055/s-0028-1089942
  21. Zhu H, Zhang G, Yi X, et al. Histology subtypes and polyp size are associated with synchronous colorectal carcinoma of colorectal serrated polyps: a study of 499 serrated polyps. Am J Cancer Res 2015;5:363-374.
  22. Rex DK, Ahnen DJ, Baron JA, et al. Serrated lesions of the colorectum: review and recommendations from an expert panel. Am J Gastroenterol 2012;107:1315-1329; quiz 1314, 1330. https://doi.org/10.1038/ajg.2012.161
  23. Saito S, Tajiri H, Ikegami M. Serrated polyps of the colon and rectum: endoscopic features including image enhanced endoscopy. World J Gastrointest Endosc 2015;7:860-871. https://doi.org/10.4253/wjge.v7.i9.860
  24. Makinen MJ. Colorectal serrated adenocarcinoma. Histopathology 2007;50:131-150. https://doi.org/10.1111/j.1365-2559.2006.02548.x
  25. Carr NJ, Mahajan H, Tan KL, Hawkins NJ, Ward RL. Serrated and non-serrated polyps of the colorectum: their prevalence in an unselected case series and correlation of BRAF mutation analysis with the diagnosis of sessile serrated adenoma. J Clin Pathol 2009;62:516-518. https://doi.org/10.1136/jcp.2008.061960
  26. Kim KM, Lee EJ, Ha S, et al. Molecular features of colorectal hyperplastic polyps and sessile serrated adenoma/polyps from Korea. Am J Surg Pathol 2011;35:1274-1286. https://doi.org/10.1097/PAS.0b013e318224cd2e
  27. Spring KJ, Zhao ZZ, Karamatic R, et al. High prevalence of sessile serrated adenomas with BRAF mutations: a prospective study of patients undergoing colonoscopy. Gastroenterology 2006;131:1400-1407. https://doi.org/10.1053/j.gastro.2006.08.038
  28. Gurudu SR, Heigh RI, De Petris G, et al. Sessile serrated adenomas: demographic, endoscopic and pathological characteristics. World J Gastroenterol 2010;16:3402-3405. https://doi.org/10.3748/wjg.v16.i27.3402
  29. Hazewinkel Y, Lopez-Ceron M, East JE, et al. Endoscopic features of sessile serrated adenomas: validation by international experts using high-resolution white-light endoscopy and narrow-band imaging. Gastrointest Endosc 2013;77:916-924. https://doi.org/10.1016/j.gie.2012.12.018
  30. Nakao Y, Saito S, Ohya T, et al. Endoscopic features of colorectal serrated lesions using image-enhanced endoscopy with pathological analysis. Eur J Gastroenterol Hepatol 2013;25:981-988. https://doi.org/10.1097/MEG.0b013e3283614b2b
  31. Uraoka T, Higashi R, Horii J, et al. Prospective evaluation of endoscopic criteria characteristic of sessile serrated adenomas/polyps. J Gastroenterol 2015;50:555-563. https://doi.org/10.1007/s00535-014-0999-y
  32. East JE, Suzuki N, Bassett P, et al. Narrow band imaging with magnification for the characterization of small and diminutive colonic polyps: pit pattern and vascular pattern intensity. Endoscopy 2008;40:811-817. https://doi.org/10.1055/s-2008-1077586
  33. Yamashina T, Takeuchi Y, Uedo N, et al. Diagnostic features of sessile serrated adenoma/polyps on magnifying narrow band imaging: a prospective study of diagnostic accuracy. J Gastroenterol Hepatol 2015;30:117-123.

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