Journal of Korean Traditional Oncology (대한암한의학회지)

Korean Association of Traditional Oncology (대한암한의학회)
권호 표지
DOI QR코드

DOI QR Code

Development of a Guidelines of the Herbal Medicine Treatment for Gastric Cancer on the Use of Systemic Review and Delphi Technique

체계적 문헌 고찰과 델파이 기법을 활용한 위암의 한약 치료에 관한 한의표준임상진료 지침 개발

  • Song, Si Yeon (East West Cancer Center, Dunsan Korean Medicine Hospital of Daejeon University) ;
  • Ban, Kyung-tae (East West Cancer Center, Dunsan Korean Medicine Hospital of Daejeon University) ;
  • Ha, Su-jeung (East West Cancer Center, Dunsan Korean Medicine Hospital of Daejeon University) ;
  • Park, So-jung (East West Cancer Center, Dunsan Korean Medicine Hospital of Daejeon University) ;
  • Lee, Yeon-weol (East West Cancer Center, Dunsan Korean Medicine Hospital of Daejeon University) ;
  • Cho, Chong-kwan (East West Cancer Center, Dunsan Korean Medicine Hospital of Daejeon University) ;
  • Cho, Seung-Hun (Department of Neuropsychiatry, College of Korean Medicine, Kyunghee University) ;
  • Yoo, Hwa-Seung (East West Cancer Center, Dunsan Korean Medicine Hospital of Daejeon University)
  • 송시연 (대전대학교 둔산한방병원 동서암센터) ;
  • 반경태 (대전대학교 둔산한방병원 동서암센터) ;
  • 하수정 (대전대학교 둔산한방병원 동서암센터) ;
  • 박소정 (대전대학교 둔산한방병원 동서암센터) ;
  • 이연월 (대전대학교 둔산한방병원 동서암센터) ;
  • 조종관 (대전대학교 둔산한방병원 동서암센터) ;
  • 조성훈 (경희대학교 한의과대학 한방신경정신과) ;
  • 유화승 (대전대학교 둔산한방병원 동서암센터)
  • Published : 2018.06.30
Download PDF
⟨ Previous Next ⟩

Abstract

Objectives: This study was conducted towards developing guidelines of herbal medicine treatment for gastric cancer. Methods: We performed a systematic review and meta-analysis designed to investigate the efficacy of herbal medicine treatment for gastric cancer on four cancer questions; survival rate, metastasis, immune function, and quality of life. Based on the findings, we utilized a two-round delphi process with panel of 22 experts for their level of agreement. Results: Combined therapy group, herbal medicine treated with chemotherapy, was significantly higher in the 1-year survival rate (RR=1.27, 95% CI: 1.14 to 1.40, P=0.005, $I^2=71%$) and 3-years survival rate (RR=1.41, 95% CI: 1.16 to 1.71, P=0.91, $I^2=0%$) than chemotherapy group. The suppression of metastasis was higher in the combined therapy group (RR=0.62, 95% CI: 0.45 to 0.84, P=0.09, $I^2=54%$). The immunology function was higher in the combined therapy group compared with the chemotherapy group (MD=16.43, 95% CI: 13.25 to 29.61, P<0.001, $I^2=99%$). The quality of life score was higher in the combined therapy group compared with the chemotherapy group (RR=1.55, 95% CI: 1.21 to 2.00, P<0.66, $I^2=0%$). Conclusions: Among the Randomized controlled trials (RCT) included, the levels of survival rates, suppression of metastasis, immune function, and quality of life of the group treated with chemotherapy were lower compared to those treated with herbal medicine in addition to chemotherapy.

Keywords

References

  1. Torre LA, Siegel RL, Ward EM, Jemal A. Global cancer incidence and mortality rates and trends-An update. Cancer Epidemiol Biomarkers Prev. 25(1):16-27, 2016 https://doi.org/10.1158/1055-9965.EPI-15-0578
  2. Wagner AD, Grothe W, Haerting J, Kleber G, Grothey A, Fleig WE. Chemotherapy in advanced gastric cancer: a systematic review and meta-analysis based on aggregate data. J Clin Oncol. 24(18):2903-2909, 2006 https://doi.org/10.1200/JCO.2005.05.0245
  3. Korea Central Cancer Registry, National Cancer Center. Annual report of cancer statistics in Korea in 2015. Ministry of Health and Welfare. 2017
  4. Foo M, Leong T. Adjuvant therapy for gastric cancer: current and future directions. World J Gastroenterol. 20:13718-13727, 2014 https://doi.org/10.3748/wjg.v20.i38.13718
  5. Paoletti X, Oba K, Burzykowski T, Michiels S, Ohashi Y, Pignon J, Rougier P, Sakamoto J, Sargent D, Sasako M, Van Custem E, Buyse M. Benefit of adjuvant chemotherapy for resectable gastric cancer: a meta-analysis. JAMA. 303(17):1729-1737, 2010 https://doi.org/10.1001/jama.2010.534
  6. Kwon SJ. Investigation of long-term survivors with stage IV gastric cancer. Journal of the Korean Gastric Cancer Association. 2(3):157-162, 2002 https://doi.org/10.5230/jkgca.2002.2.3.157
  7. Kim MH, Kang PS, Lee KS, Hwang TY, Maxwell AE. Utilization of complementary and alternative medicine of cancer patient in Korea. Journal of Agricultural Medicine and Community Health. 32(3):155-167, 2007 https://doi.org/10.5393/JAMCH.2007.32.3.155
  8. Jung JH, Seo JC, Kwak MA, Sohn KC. Literature review on traditional Chinese medicine treatment of gastric cancer. J Korean Oriental Intern Med. 35:332-342, 2014
  9. Lee YK, Bae KY, Yoo HS. Benefit of adjuvant traditional herbal medicine with chemotherapy for resectable gastric cancer. Integrative cancer therapies. 1534735417753542, 2018
  10. Review Manager (RevMan) [Computer program]. Version 5.3. Copenhagen: The Nordic Cochrane Centre, The Cochrane Collaboration, 2014
  11. Guyatt GH, Oxman AD, Vist GE, Kunz R, Falck-Ytter Y, Alonso-Coello P, Schuemann HJ. GRADE: an emerging consensus on rating quality of evidence and strength of recommendations. BMJ. 336:924-9246, 2008 https://doi.org/10.1136/bmj.39489.470347.AD
  12. Li X, Wei P. Effect observation about Jinlongshe for oral use treating advanced gastric carcinoma. Hubei Journal of Traditional Chinese Medicine. 23(11):3-5, 2001
  13. Wang HZ, Wang HB, Gao H. Clinical observation on treatment of 34 advanced gastric carcinoma patients by chemotherapy of DCF regimen combined with Fuzheng Hewei Decoction. Zhongguo Zhong Xi Yi Jie He Za Zhi. 27(10):927-929, 2007
  14. Yang JK, Zhen J, Shen KP. Clinical study on post-operative metastasis prevention of progressive stage of gastric cancer by weichang'an. Zhongguo Zhong Xi Yi Jie He Za Zhi. 23(8):580-582, 2003
  15. Yang Z, You J. No 3 readjust of Chinese medicine treat advanced gastric carcinoma by differentiation of symptoms and signs. Liaoning Journal of Traditional Chinese Medicine. 33(11):1434-1435, 2006
  16. You J, Zhao J. Readjusting and balancing methods of doctor Zhao treat advanced gastric cancer of 176 cases. Jilin Journal of Chinese Medicine. 20(5):10-11, 2000
  17. Zhou H, Zheng J, Shen KP. Clinical study on Wei Chang An recipe in the treatment of advanced gastric cancer. Tumor. 27(6):487-489, 2007
  18. Bu P. The effects of Chinese drugs for supporting healthy energy and removing blood stasis on postoperative metastasis of gastric carcinoma and ornithine decarboxylase. J Tradit Chin Med. 18(1):3, 1998
  19. Liu YX, Jiang SJ, Kuang TH, Yao YW, Yang JW, Wang YQ. Treatment with yiqi bushen koufuye combined with chemotherapy for preventing postoperative metastasis of stomach cancer--a clinical observation of 28 cases. J Tradit Chin Med. 29(4):263-267, 2009 https://doi.org/10.1016/S0254-6272(09)60078-9
  20. Yu QS, Liu Y, Hou Y, et al. Effect of early intestinal dripping of jianpi tongli Chinese herbs on serum level IL-2, sIL-2R and IL-12 in patients with gastric cancer after operation. Zhongguo Zhong Xi Yi Jie He Za Zhi. 25(8):710-713, 2005
  21. Zhu JS, Song MQ, Wang L, Sun Q, Zhu L, Fang C. Immunoregulation and short-term therapeutic effects of super-selective intra-arterial chemotherapy combined with traditional Chinese drugs on gastric cancer patients. Zhong Xi Yi Jie He Xue Bao. 4(5):478-481, 2006 https://doi.org/10.3736/jcim20060507
  22. Cai J, Xuan ZR, Wei YP, Yang HB, Wang H. Effects of perioperative administration of Rhubarb on acute inflammatory response in patients with gastric cancer. Zhong Xi Yi Jie He Xue Bao. 3(3):195-198, 2005 https://doi.org/10.3736/jcim20050309
  23. Wang H, Guo LJ, Wu B, et al. Effect of rhubarb combined with enteral nutrition on C-reactive protein and interleukin-6 in peripheral blood of patients with gastric cancer during perioperative period. Zhongguo Zhong Xi Yi Jie He Za Zhi. 28(2):101-104, 2008
  24. Cai J, Wang H, Zhou S, Wu B, Song HR, Xuan ZR. Effect of Sijunzi Decoction and enteral nutrition on T-cell subsets and nutritional status in patients with gastric cancer after operation: a randomized controlled trial. Zhong Xi Yi Jie He Xue Bao. 6(1):37-40, 2008 https://doi.org/10.3736/jcim20080108
  25. Hua B, Wang A. Clinical study on treatment of mid-late stage gastric carcinoma by composite xiansu capsule combined with chemotherapy. Zhongguo Zhong Xi Yi Jie He Za Zhi. 19(8):470-472, 1999
  26. Meng Y, Cao F, Jun C, Chen P. Fifty cases of postoperative gastric cancer treated with combined therapy of traditional Chinese and conventional chemotherapy. Global Traditional Chinese Medicine. 8(8):995-997, 2015
  27. Cheon CH, Park SJ, Jang BH, Shin YC, Ko SG. The analysis of usage of symptom differentiation in clinical trials in Korean medicine for cancer patients. spkom. 19(1):61-70, 2015
  28. Hung KF, Hsu CP, Chiang JH, Lin HJ, Kuo YT, Sun MF, Yen HR. Complementary Chinese herbal medicine therapy improves survival of patients with gastric cancer in Taiwan: A nationwide retrospective matched-cohort study. Journal of ethnopharmacology. 199:168-174, 2017 https://doi.org/10.1016/j.jep.2017.02.004
  29. Kim YH, Lim Y, Cho JY, Chung IJ, Kim JG, Lee KH, Oh D. Korean red ginseng to improve cancer-related fatigue in colorectal cancer patients with FOLFOX chemotherapy: A randomized, double-blind, placebo-controlled, parallel, multicenter trial, NCT02039635. Journal of Clinical Oncology. 35:10008, 2017 https://doi.org/10.1200/JCO.2017.35.15_suppl.10008