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Small Cell Carcinoma of the Ovary Hypercalcemic Type: A Case Report

난소에서 발생한 고칼슘 형태의 소세포암: 증례 보고

  • Nam, Yeo Kyoung (Department of Radiology, Keimyung University School of Medicine, Dongsan Medical Center) ;
  • Kim, See Hyung (Department of Radiology, Keimyung University School of Medicine, Dongsan Medical Center) ;
  • Choi, Mi Sun (Department of Pathology, Keimyung University School of Medicine, Dongsan Medical Center)
  • 남여경 (계명대학교 의과대학 동산의료원 영상의학과) ;
  • 김시형 (계명대학교 의과대학 동산의료원 영상의학과) ;
  • 최미선 (계명대학교 의과대학 동산의료원 병리과)
  • Received : 2017.07.18
  • Accepted : 2017.11.30
  • Published : 2018.06.01

Abstract

Small cell carcinoma of the ovary, hypercalcemic type is a rare ovarian tumor. This tumor has three distinctive clinical features: i) an occurrence in young women, ii) the presence of hypercalcemia in 62% of cases, and iii) a high degree of malignancy. The radiologic findings of the tumors are usually large and a predominantly solid mass with internal necrosis, hemorrhage and cystic degeneration. We report on the CT and MRI findings of an ovarian small cell carcinoma, hypercalcemic type in a 17-year-old female who presented 1 month abdominal discomfort with weight loss.

난소의 원발성 소세포암은 매우 드문 난소 종양으로 주로 젊은 여성에서 발생하며 약 62%에서 고칼슘혈증을 동반하는 악성 종양이다. 영상검사에서 일반적으로 고형성 종양 내부에 부분적 낭성 변화 및 괴사를 동반하는 형태로 관찰된다. 저자들은 복통, 체중감소를 주소로 내원한 17세 여성에서 고칼슘 형태의 난소 소세포암 1예를 경험하였기에 문헌고찰과 함께 보고하고자 한다.

Keywords

References

  1. Remick SC, Ruckdeschel JC. Extrapulmonary and pulmonary small-cell carcinoma: tumor biology, therapy, and outcome. Med Pediatr Oncol 1992;20:89-99 https://doi.org/10.1002/mpo.2950200202
  2. Young RH, Oliva E, Scully RE. Small cell carcinoma of the ovary, hypercalcemic type. a clinicopathological analysis of 150 cases. Am J Surg Pathol 1994;18:1102-1116 https://doi.org/10.1097/00000478-199411000-00004
  3. Dickersin GR, Kline IW, Scully RE. Small cell carcinoma of the ovary with hypercalcemia; a report of eleven cases. Cancer 1982;49:188-197 https://doi.org/10.1002/1097-0142(19820101)49:1<188::AID-CNCR2820490137>3.0.CO;2-D
  4. Witkowski L, Goudie C, Foulkes WD, McCluggage WG. Smallcell carcinoma of the ovary of hypercalcemic type (malignant rhabdoid tumor of the ovary): a review with recent developments on pathogenesis. Surg Pathol Clin 2016;9;215-226 https://doi.org/10.1016/j.path.2016.01.005
  5. Matias-Guiu X, Prat J, Young RH, Capen CC, Rosol TJ, DeLellis RA, et al. Human parathyroid hormone-related protein in ovarian small cell carcinoma. Cancer 1994;73:1878-1881 https://doi.org/10.1002/1097-0142(19940401)73:7<1878::AID-CNCR2820730717>3.0.CO;2-D
  6. Barkhru A, Liu JR, Lagstein A. A case of small cell carcinoma of the ovary hypercalcemic variant in a teenager. Gynecol Oncol Case Rep 2012;2:139-142 https://doi.org/10.1016/j.gynor.2012.09.001
  7. Park SH, Kim YT, Kim SW, Yang SH. Ovarian small cell carcinoma in a 12 year old girl: a case report. J Korean Soc Radiol 2009;60:353-356 https://doi.org/10.3348/jksr.2009.60.5.353
  8. Kim JY, Kim YJ, Seong HJ, Park WY, Hong YS, Do YR, et al. [Primary small cell carcinoma of the ovary and the longterm survival after systemic chemotherapy]. Korean J Med 2007:72;563-567
  9. Callegaro-Filho D, Gershenson DM, Nick AM, Munsell MF, Ramirez PT, Eifel PJ, et al. Small cell carcinoma of the ovaryhypercalcemic type (SCCOHT): a review of 47 cases. Gynecol Oncol 2016;140:53-57 https://doi.org/10.1016/j.ygyno.2015.11.004