Textile Coloration and Finishing (한국염색가공학회지)

The Korean Society of Dyers and Finishers (한국염색가공학회)
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Preparation and Biocompatibility of Medical Fiber from Novel Regenerated Cellulose from Styela clava tunic

미더덕껍질의 재생셀룰로오스를 이용한 의료용 섬유의 제조 및 생체적합성

  • Song, Sung Hwa (Department of Biomaterials Science, Pusan National University) ;
  • Kim, Ji Eun (Department of Biomaterials Science, Pusan National University) ;
  • Choi, Jun Young (Department of Biomaterials Science, Pusan National University) ;
  • Park, Jin Ju (Department of Biomaterials Science, Pusan National University) ;
  • Lee, Mi Rim (Department of Biomaterials Science, Pusan National University) ;
  • Song, Bo Ram (Department of Biomaterials Science, Pusan National University) ;
  • Lee, Yechan (Department of Biomaterials Science, Pusan National University) ;
  • Kim, Hong Sung (Department of Biomaterials Science, Pusan National University) ;
  • Lee, Jae Ho (Department of Biomaterials Science, Pusan National University) ;
  • Lim, Yong (Department of Clinical Laboratory Science,Dong-Eui University) ;
  • Hwang, Dae Youn (Department of Biomaterials Science, Pusan National University) ;
  • Jung, Young Jin (Department of Biomaterials Science, Pusan National University)
  • 송성화 (부산대학교 바이오소재과학과) ;
  • 김지은 (부산대학교 바이오소재과학과) ;
  • 최준영 (부산대학교 바이오소재과학과) ;
  • 박진주 (부산대학교 바이오소재과학과) ;
  • 이미림 (부산대학교 바이오소재과학과) ;
  • 송보람 (부산대학교 바이오소재과학과) ;
  • 이예찬 (부산대학교 바이오소재과학과) ;
  • 김홍성 (부산대학교 바이오소재과학과) ;
  • 이재호 (부산대학교 바이오소재과학과) ;
  • 임용 (동의대학교 임상병리학과) ;
  • 황대연 (부산대학교 바이오소재과학과) ;
  • 정영진 (부산대학교 바이오소재과학과)
  • Received : 2018.03.15
  • Accepted : 2018.04.30
  • Published : 2018.06.27
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Abstract

Cellulose has been widely applied into various medical fields including scaffolding, tissue engineering and tissue formation. In this study, we manufactured cellulose medical fiber from Styela clava tunics(SCT-CS) and analyzed the tensile strength, elongation at break, fluid uptake and surface morphology. And then, the biocompatibility and toxicity of SCT-CS were measured in Sprague-Dawley(SD) rats after the implantation for 30, 60 and 90 days. The level of tensile strength and fluid uptake were lower in SCT-CS than chromic catgut(CCG), while elongation at break level were maintained the higher in SCT-CS. Also, the roughness with pronounced surface patterns as a result of in vivo degradation was significantly greater in CCG than this of SCT-CS although these levels gradually appeared with time in both groups. After implantation for 90 days, SCT-CS and CCG was successfully implanted around muscle of thigh without any significant immune response. Furthermore, no significant alterations were measured in serum parameters and the specific pathological features induced by most toxic compounds for liver and kidney toxicity. Therefore, these results suggest that SCT-CS showing good biocompatibility and non-toxicity can be successfully prepared from cellulose powder of SCT as well as has the potential for use as a powerful biomaterial for medical sutures.

Keywords

References

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